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Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

Nature volume 323, pages 226–232 (1986)Cite this article

Abstract

The primary structure of the receptor for platelet-derived growth factor (PDGF), determined by means of cloning a cDNA that encodes the murine pre-PDGF receptor, is closely related to that of the v-kit oncogene product and the receptor for macrophage colony stimulating factor (CSF-1). Common structural features include the presence of long sequences that interrupt the tyrosine-specific protein kinase domains of each molecule. The PDGF and CSF-1 receptors also share a characteristic distribution of extracellular cysteine residues. Ubiquitin is covalently bound to the purified PDGF receptor, the human gene for which is on chromosome 5.

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Authors and Affiliations

  1. Departments of Molecular and Developmental Biology, Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, California, 94080, USA

    Y. Yarden, W-J. Kuang, E. Y. Chen, R. N. Harkins & A. Ullrich

  2. Howard Hughes Medical Institute, Department of Medicine and Cardiovascular Research Institute, University of California, Box 0724, San Francisco, California, 94143, USA

    J. A. Escobedo, T. O. Daniel, P. M. Tremble & L. T. Williams

  3. Department of Human Genetics, Yale University School of Medicine, PO Box 333, New Haven, Connecticut, 06510, USA

    T. L. Yang-Feng & U. Francke

  4. Department of Biochemistry, St Jude Children's Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA

    M. E. Ando & V. A. Fried

  5. Department of Protein Chemistry, Triton Bio-sciences Inc., Alameda, California, 94501, USA

    R. N. Harkins

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Yarden, Y., Escobedo, J., Kuang, WJ. et al. Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature 323, 226–232 (1986). https://doi.org/10.1038/323226a0

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