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Correlations between T-cell specificity and the structure of the antigen receptor

Nature volume 321, pages 219–226 (1986)Cite this article

Abstract

The derived amino-acid sequences of the heterodimeric antigen receptors expressed by a series of murine T-cell clones are presented. A comparison of the receptor sequences indicates that several mechanisms for generating receptor diversity can influence T-cell specificity, including junctional diversity, combinatorial joining, and combinatorial chain associations.

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Authors and Affiliations

  1. Department of Biology, Cancer Center, M-001, University of California, San Diego, La Jolla, California, 92093, USA

    Pamela J. Fink, David L. McElligott & Stephen M. Hedrick

  2. Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland, 20892, USA

    Louis A. Matis & Michael Bookman

Authors
  1. Pamela J. Fink
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  2. Louis A. Matis
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  3. David L. McElligott
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  4. Michael Bookman
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  5. Stephen M. Hedrick
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Fink, P., Matis, L., McElligott, D. et al. Correlations between T-cell specificity and the structure of the antigen receptor. Nature 321, 219–226 (1986). https://doi.org/10.1038/321219a0

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