Nature 320, 584 - 588 (17 April 1986); doi:10.1038/320584a0

Cachectin and tumour necrosis factor as two sides of the same biological coin

Bruce Beutler & Anthony Cerami

Laboratory of Medical Biochemistry, The Rockefeller University, New York, New York 10021, USA

In response to invasive stimuli, macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.

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