Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Unique allelic restriction fragments of the human Ha-ras locus in leukocyte and tumour DNAs of cancer patients

Abstract

White blood cell DNA from cancer patients and DNA from tumours and tumour-derived cell lines frequently demonstrated allelic restriction fragments of the Harvey ras oncogene locus not found in the unaffected population. The presence of such unusual alleles may be linked to susceptibility to cancer.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Cooper, G. M. Science 218, 801–806 (1982).

    Article  ADS  Google Scholar 

  2. Bishop, J. M. Cell 32, 1018–1020 (1983).

    Article  CAS  Google Scholar 

  3. Parada, L. F., Tabin, C. J., Shih, C. & Weinberg, R. H. Nature 297, 474–478 (1982).

    Article  ADS  CAS  Google Scholar 

  4. Santos, E. et al. Nature 298, 343–347 (1982).

    Article  ADS  CAS  Google Scholar 

  5. Der, C. J. et al. Proc. natn. Acad. Sci. U.S.A. 79, 3637–3640 (1982).

    Article  ADS  CAS  Google Scholar 

  6. Tabin, C. J. et al. Nature 300, 143–149 (1982).

    Article  ADS  CAS  Google Scholar 

  7. Reddy, E. P., Reynolds, R. K., Santos, E. & Barbacid, M. Nature 300, 149–152 (1982).

    Article  ADS  CAS  Google Scholar 

  8. Shimizu, K. et al. Nature 304, 497–500 (1983).

    Article  ADS  CAS  Google Scholar 

  9. Capon, D. J. et al. Nature 304, 507–513 (1983).

    Article  ADS  CAS  Google Scholar 

  10. Murray, M. J. et al. Cell 33, 749–757 (1983).

    Article  CAS  Google Scholar 

  11. Eva, A., Tronick, S. R., Gol, R. A., Pierce, J. H. & Aaronson, S. A. Proc. natn. Acad. Sci. U.S.A. 80, 4926–4930 (1983).

    Article  ADS  CAS  Google Scholar 

  12. Shih, C., Padhy, L. C., Murray, M. & Weinberg, R. A. Nature 290, 261–264 (1981).

    Article  ADS  CAS  Google Scholar 

  13. Perucho, M. et al. Cell 27, 467–476 (1981).

    Article  CAS  Google Scholar 

  14. Krontiris, T. G. & Coper, G. M. Proc. natn. Acad. Sci. U.S.A. 78, 1181–1184 (1981).

    Article  ADS  CAS  Google Scholar 

  15. Murray, M. J. et al. Cell 25, 355–361 (1981).

    Article  CAS  Google Scholar 

  16. Pulciani, S. et al. Proc. natn. Acad. Sci. U.S.A. 79, 2845–2849 (1982).

    Article  ADS  CAS  Google Scholar 

  17. Marshall, C. J., Hall, A. & Weiss, R. A. Nature 299, 171–173 (1982).

    Article  ADS  CAS  Google Scholar 

  18. Pulciani, S. et al. Nature 300, 539–542 (1982).

    Article  ADS  CAS  Google Scholar 

  19. Goldfarb, M., Shimizu, K., Perucho, M. & Wigler, M. Nature 296, 404–409 (1982).

    Article  ADS  CAS  Google Scholar 

  20. Capon, D. J., Chen, E. Y., Levinson, A. D., Seeburg, P. H. & Goeddel, D. V. Nature 302, 33–37 (1983).

    Article  ADS  CAS  Google Scholar 

  21. Collins, S. J. & Groudine, M. Nature 298, 679–681 (1982).

    Article  ADS  CAS  Google Scholar 

  22. Schwab, M., Alitado, K., Varmus, H. E., Bishop, J. M. & George, D. Nature 303, 497–501 (1983).

    Article  ADS  CAS  Google Scholar 

  23. Benedict, W. F. et al. Science 219, 973–975 (1983).

    Article  ADS  CAS  Google Scholar 

  24. Cavenee, W. J. et al. Nature 305, 779–784 (1983).

    Article  ADS  CAS  Google Scholar 

  25. Koufos, A. et al. Nature 309, 170–172 (1984).

    Article  ADS  CAS  Google Scholar 

  26. Orkin, S. H., Goldman, D. S. & Sallon, S. E. Nature 309, 172–174 (1984).

    Article  ADS  CAS  Google Scholar 

  27. Reeve, A. E. et al. Nature 309, 174–176 (1984).

    Article  ADS  CAS  Google Scholar 

  28. Fearon, E. R., Vogelstein, B. & Feinberg, A. P. Nature 309, 176–178 (1984).

    Article  ADS  CAS  Google Scholar 

  29. Chang, E. H., Furth, M. E., Scolnick, E. M. & Lowry, D. R. Nature 297, 479–483 (1982).

    Article  ADS  CAS  Google Scholar 

  30. Southern, E. M. J. molec. Biol. 98, 503–513 (1975).

    Article  CAS  Google Scholar 

  31. Maniatis, T., Jeffrey, A. & Kleid, D. G. Proc. natn. Acad. Sci. U.S.A. 72, 1184–1188 (1975).

    Article  ADS  CAS  Google Scholar 

  32. Seeburg, P. H. et al. Nature 312, 71–75 (1984).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Krontiris, T., DiMartino, N., Colb, M. et al. Unique allelic restriction fragments of the human Ha-ras locus in leukocyte and tumour DNAs of cancer patients. Nature 313, 369–374 (1985). https://doi.org/10.1038/313369a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/313369a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing