Nature 308, 428 - 433 (29 March 1984); doi:10.1038/308428a0

A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes

W. McGinnis, M. S. Levine^*, E. Hafen^*, A. Kuroiwa & W. J. Gehring

Department of Cell Biology, Biocenter, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland
^*Present address: Department of Biochemistry, University of California, Berkeley, California 94720, USA

A repetitive DNA sequence has been identified in the Drosophila melanogaster genome that appears to be localized specifically within genes of the bithorax and Antennapedia complexes that are required for correct segmental development. Initially identified in cloned copies of the genes Antennapedia, Ultrabithorax and fushi tarazu, the sequence is also contained within two other DNA clones that have characteristics strongly suggesting that they derive from other homoeotic genes.

References

1.	Lewis, E. B. Nature 276, 565−570 (1978). | PubMed | ISI | ChemPort |
2.	Kaufman, T. C., Lewis, R. & Wakimoto, B. Genetics 94, 115−133 (1980). | ISI |
3.	Lewis, R. A., Wakimoto, B. T., Denell, R. E. & Kaufman, T. C. Genetics 95, 383−397 (1980). | ISI |
4.	Wakimoto, B. T. & Kaufman, T. C. Devl Biol. 81, 51−64 (1981). | ChemPort |
5.	Hazelrigg, T. & Kaufman, T. C. Genetics 105, 581−600 (1983). | ISI |
6.	Le Calvez, J. Bull. biol. Fr. Belg. 82, 97−113 (1948).
7.	Hannah, A. & Strömnaes, O. Drosoph. Inf. Serv. 29, 121−123 (1955).
8.	Garcia-Bellido, A. Am. Zool. 17, 613−629 (1977).
9.	Duncan, I. & Lewis, E. B. Developmental Order: Its Origin and Regulation, 533−554 (Alan R. Liss, New York, 1982).
10.	Struhl, G. Proc. natn. Acad. Sci. U.S.A. 79, 7380−7384 (1982). | ChemPort |
11.	Struhl, G. J. Embryol. exp. Morph. 76, 297−331 (1983). | PubMed | ISI | ChemPort |
12.	Hafen, E., Levine, M. & Gehring, W. J. Nature 307, 287−289 (1984). | PubMed | ISI | ChemPort |
13.	Garber, R. L., Kuroiwa, A. & Gehring, W. J. EMBO J. 2, 2027−2036 (1983). | PubMed | ISI | ChemPort |
14.	Nüsslein-Volhard, C., Wieschaus, E. & Jürgens, G. Verh. dt zool. Ges., 91−104 (1982).
15.	Bender, W. et al. Science 221, 23−29 (1983). | ISI | ChemPort |
16.	Akam, M. EMBO J. 2, 2075−2084 (1983). | PubMed | ISI | ChemPort |
17.	Scott, M. P. et al. Cell (in the press).
18.	Hafen, E., Levine, M., Garber, R. L. & Gehring, W. J. EMBO J. 2, 617−623 (1983). | ISI | ChemPort |
19.	Levine, M., Hafen, E., Garber, R. L. & Gehring, W. J. EMBO J. 2, 2037−2046 (1983). | PubMed | ISI | ChemPort |
20.	Maniatis, T. et al. Cell 15, 687−701 (1978). | Article | PubMed | ISI | ChemPort |
21.	Langer-Sofer, P. R., Levine, M. & Ward, D. C. Proc. natn. Acad. Sci. U.S.A. 79, 4381−4385 (1982). | ChemPort |
22.	Bender, W., Spierer, P. & Hogness, D. S. J. molec. Biol. 168, 17−33 (1983). | PubMed | ISI | ChemPort |
23.	Kaufman, T. C. Genetics 90, 579−596 (1978). | ISI |
24.	Morata, G. & Garcia-Bellido, A. Wilhelm Roux's Arch. dev. Biol. 179, 125−143 (1976).
25.	Sanchez-Herrero, E. & Morata, G. J. Embryol. exp. Morph. 76, 251−264 (1983). | PubMed | ChemPort |
26.	Morata, G. & Kerridge, S. Nature 290, 778−781 (1981). | PubMed | ISI | ChemPort |
27.	Poulson, D. F. Biology of Drosophila, 168−274 (ed. Demereo, M.) (Wiley, New York, 1950).
28.	Chan, L. N. & Gehring, W. J. Proc. natn. Acad. Sci. U.S.A. 68, 2217−2221 (1971). | ChemPort |
29.	Wieschaus, E. & Gehring, W. J. Devl Biol. 50, 249−263 (1976). | ChemPort |
30.	Underwood, E. M., Turner, F. R. & Mahowald, A. P. Devl Biol. 74, 286−301 (1980). | ChemPort |
31.	Southern, E. J. molec. Biol. 98, 503−517 (1975). | PubMed | ISI | ChemPort |
32.	Goldberg, D. A. Proc. natn. Acad. Sci. U.S.A. 77, 5794−5799 (1980). | ChemPort |