Abstract
Formylmethionyl-tRNA (F-Met-tRNAF) is bound by particular codons to ribosomes in the initiation of protein synthesis. When a certain small concentration of magnesium ions is present, initiation factors and GTP are also required for this binding to take place. An analogue can be substituted for GTP, which suggests that this role of the nucleotide is uncoupled from its later hydrolysis.
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ANDERSON, J., BRETSCHER, M., CLARK, B. et al. A GTP Requirement for Binding Initiator tRNA to Ribosomes. Nature 215, 490–492 (1967). https://doi.org/10.1038/215490a0
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DOI: https://doi.org/10.1038/215490a0
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