Cell Research

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Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor big gamma

Xiaoqi Li, Xuanming Yang, Youli Xu, Xuejun Jiang, Xin Li, Fajun Nan and Hong Tang

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Supplementary information, Figure S1 (pdf 251K)

TGZ–induced transient activation of Erk1/2 and down–regulation of EGFR is independent of PPAR–gamma.

Supplementary information, Figure S2 (pdf 120K)

TGZ inhibits cell proliferation independent of Erk1/2 activation.

Supplementary information, Figure S3 (pdf 107K)

MMP-dependent cleavage of pro-EGF ligands participates in TGZ-induced transactivation of EGFR-Erk1/2 but not in down-regulation of EGFR.

Supplementary information, Figure S4 (pdf 90K)

TGZ and EGF inhibit tumor cell proliferation.

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