Cell Research

FIGURE 2

FROM:

Genomic analysis of epithelial ovarian cancer

John Farley, Laurent L Ozbun and Michael J Birrer

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Figure 2.

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Model of the development of an epithelial ovarian tumor. Incessant ovulation and wound repair increases the risk of genetic abnormalities, leading to dysplastic changes in epithelial cells lining the mullerian inclusion cyst. Stromal microenvironment in the forms of activated fibroblast formation, microvessel proliferation, and growth factors contributes to dysplastic formation and eventual malignant transformation.

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