FIGURE 5
FROM:
MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth
Julia Schultz, Peter Lorenz, Gerd Gross, Saleh Ibrahim and Manfred Kunz
BACK TO ARTICLEFigure 5.
Influence of let-7b on colony formation of melanoma cell in vitro. G361 melanoma cells were transfected for 48 h with 30 nM let-7b or control precursor microRNA and grown in soft agar for 20 days at 37 °C. (A) High-power views (
100 magnification) of colonies from one representative experiment. (B) Graphic presentation of numbers of colony-forming units from three independent experiments. Data in (B) are given as mean values +/-
SD. Asterisk indicates statistical significance of the difference in number of colonies of let-7b-transfected compared with control miRNA-transfected cells (P < 0.05; Mann-Whitney-U test).
