FIGURE 4
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MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth
Julia Schultz, Peter Lorenz, Gerd Gross, Saleh Ibrahim and Manfred Kunz
BACK TO ARTICLEFigure 4.
Influence of let-7b on cell cycle progression of melanoma cells. SK-Mel-147 melanoma cells were transfected for 48 h with 30 nM let-7b precursor microRNA (Pre-let-7b) or anti-let-7b antagomir. Cell cycle analysis was performed by flow cytometry. Data are given as mean values +/- SD of three independent experiments. Asterisks indicate statistical significance of differences in the number of cells in G0-G1, S, or G2-M between Pre-let-7b- or anti-let7b-transfected versus control transfected cells (P < 0.05; Mann-Whitney-U test).
