Cell Research

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Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor

Alexey E Granovsky and Marsha Rich Rosner

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Figure 1.

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Two different cartoon representations of the x-ray crystal structure of rat RKIP (PDB Id#2iqy). Residues comprising the ligand binding pocket are shown in orange. The site of a naturally occurring pocket mutation in the conserved DPDxP motif (Pro74) and the site of RKIP phosphorylation by growth activating kinases (Ser153) are shown as blue spheres.

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