Review
Cell Research (2008) 18:3–7. doi: 10.1038/cr.2007.113; published online 24 December 2007
A brief history of the DNA repair field
Errol C Friedberg1
1Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
Correspondence: Errol C Friedberg, E-mail: errol.friedberg@utsouthwestern.edu
Abstract
The history of the repair of damaged DNA can be traced to the mid-1930s. Since then multiple DNA repair mechanisms, as well as other biological responses to DNA damage, have been discovered and their regulation has been studied. This article briefly recounts the early history of this field.
Keywords:
DNA repair, biological responses to DNA damage, ultraviolet light, excision repair, enzymatic photoreactivation, mismatch repair, DNA damage tolerance, recombination
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