Cell Research

FIGURE 4

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Long-term modifications of blood pressure in normotensive and spontaneously hypertensive rats by gene delivery of rAAV-mediated cytochrome P450 arachidonic acid hydroxylase

Fan ZHANG, Chun Lian CHEN, Jia Qing QIAN, Jiang Tao YAN, Katherine CIANFLONE, Xiao XIAO and Dao Wen WANG

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Figure 4.

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Northern blot analysis showing changes of CYP4A1 mRNA levels in liver and kidney of SD rats 25 weeks after delivery. A representative Northern blot images of CYP4A1 mRNA levels in response to rAAV CYP4A1 treatment. RNA loading was determined by hybridization to GAPDH; (B) Autoradiographs were scanned and relative 4A1 mRNA levels normalized to GAPDH were determined. Data shown are mean plusminus SE of three separate experiments. ** P<0.05 vs. transfection with rAAVdotLacZ (n=3).

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