Cell Research (2005) 15, 97–98. doi:10.1038/

SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci

Yong YONG1,2 and Lin HE2,3

  1. 1Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China
  2. 2Institute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
  3. 3NHGG, Bio-X Center, Shanghai Jiao Tong University, Shanghai, China

Correspondence: Lin HE, Shanghai Jiao Tong University, Bio-X Center, Hao Ran Building, 1954 Hua Shan Road, Shanghai 200030, China; or Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China. Tel & fax: 86-21-62822491; E-mail:

Received 3 January 2005; Revised 5 February 2005; Accepted 6 February 2005.



In multiloci-based genetic association studies of complex diseases, a powerful and high efficient tool for analyses of linkage disequilibrium (LD) between markers, haplotype distributions and many chi-square/p values with a large number of samples has been sought for long. In order to achieve the goal of obtaining meaningful results directly from raw data, we developed a robust and user-friendly software platform with a series of tools for analysis in association study with high efficiency. The platform has been well evaluated by several sets of real data.


software, linkage disequilibrium, haplotype analysis, genetic association study


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