Briefing

Cell Research (2005) 15, 97–98. doi:10.1038/sj.cr.7290272

SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci

Yong YONG1,2 and Lin HE2,3

  1. 1Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China
  2. 2Institute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
  3. 3NHGG, Bio-X Center, Shanghai Jiao Tong University, Shanghai, China

Correspondence: Lin HE, Shanghai Jiao Tong University, Bio-X Center, Hao Ran Building, 1954 Hua Shan Road, Shanghai 200030, China; or Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China. Tel & fax: 86-21-62822491; E-mail: helin@nhgg.org

Received 3 January 2005; Revised 5 February 2005; Accepted 6 February 2005.

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Abstract

In multiloci-based genetic association studies of complex diseases, a powerful and high efficient tool for analyses of linkage disequilibrium (LD) between markers, haplotype distributions and many chi-square/p values with a large number of samples has been sought for long. In order to achieve the goal of obtaining meaningful results directly from raw data, we developed a robust and user-friendly software platform with a series of tools for analysis in association study with high efficiency. The platform has been well evaluated by several sets of real data.

Keywords:

software, linkage disequilibrium, haplotype analysis, genetic association study

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