Review
Cell Research (2001) 11, 1–7. doi:10.1038/sj.cr.7290060
Apoptosis in oncology
Xiao Qiang FAN1 and Ya Jun GUO1
1International Joint Cancer Institute, The Second Military Medical University, Shanghai 200433, China
Correspondence: Ya Jun Guo M.D., Ph.D., Tel:0086-021-25070894, Telex:25070891, Fax: 0086-021-25070877, E-mail: yajunguosijci@aol.com
Received 8 November 2000; Revised 26 December 2000; Accepted 9 January 2001.
Abstract
Apoptosis is a complex process involving a large array of genes and mutation of any of these genes may lead to malignancy formation. Re-acquirement of FasL by tumor cells may enable them to evade the surveillance of immune system and thus contributes to the growth of tumor. Apart from traditional therapies, inducing apoptosis of tumor cell by new methods employing death receptor ligands and making use of Fas counterattack is also being developed.
Keywords:
Apoptosis, mitochondria, deathreceptor, death receptor ligand, tumor therapy
