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In January 2004 Nature Structural Biology was relaunched as Nature Structural & Molecular Biology to reflect the growing integration of structural and molecular studies. The journal places a strong emphasis on understanding the molecular mechanisms underlying biological processes.

Specific areas include (but are not limited to) DNA replication, repair and recombination; chromatin structure and remodeling; transcription; translation; the folding, processing, transport and degradation of proteins and RNA; and signaling

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