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Over one billion people — one-sixth of the world's population — suffer from
neglected tropical diseases. With the drug ‘pipeline’ for these diseases almost
dry, there is an urgent need to develop and deliver new and effective therapies.

Fortunately, the scientific community has responded with concerted research
activity aimed at addressing this shortfall; however, the successful translation
of basic scientific discoveries into novel treatments is a long, complex and
expensive process. The process becomes significantly more complicated when
dealing with diseases that disproportionally afflict poor and marginalized populations.

Despite a renewed effort over the last 10 years — largely driven through a huge
increase in philanthropic funding — the situation for those actively engaged in the
front line of the war against developing world diseases has not noticeably improved.
The continuing challenges that hinder scientific innovation from reaching the clinic
are complex, solvable, and are the focus of this Outlook.

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