Nature Reviews Genetics | Review Article
The function of the genome crucially involves regulatory sequences, such as enhancers and promoters. Many questions remain unanswered as to how these regulatory elements work, and even identifying them can be a major challenge. New genomic technologies — including transcriptomics, genome sequencing and chromatin immunoprecipitation followed by sequencing — are enabling progress in this field. The articles in this series discuss recent views on regulatory elements, including their role in evolution and the function of chromatin modifications, as well as methods to study these important regions of the genome.