Nature Outlook |

Vaccines

Vaccines have been a tremendous force for good in the world. Numerous infections that once claimed millions of lives are now preventable. But many of these pathogens are patiently waiting for an opportunity to regain a foothold, and there are still infections against which we have little defence.

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Articles

Vaccination is a life-saving intervention, infections that once killed millions are now preventable. But there is still work to be done, many pathogens remain and there are still infections against which we have little defence.

Outlook | | Nature

In 1796, English physician Edward Jenner introduced the first vaccine, for smallpox, when he infected a young boy with cowpox. In the years since, vaccines — a name derived from the Latin word for cow — have been developed for many diseases, saving millions of lives. But the fight to conquer infectious disease continues.

Outlook | | Nature

A vaccine candidate for HIV steps into phase III trials, signs emerge that antibiotics impair vaccine performance, and other highlights from clinical trials and laboratory studies.

Outlook | | Nature

As the first vaccine against the malaria parasite begins to roll out, scientists are working on a wide variety of alternatives that they hope will provide more protection.

Outlook | | Nature

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mRNA vaccines represent a promising alternative to conventional vaccine approaches, but their application has been hampered by instability and delivery issues. Here, Pardi and colleagues discuss recent advances in mRNA vaccine technology, assess mRNA vaccines currently in development for cancer and infectious diseases and consider future directions and challenges.

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The generation of an HIV vaccine remains the holy grail for eliminating HIV infection worldwide. Major advances in 2018 centred on sequential multi-immunogen strategies that are designed to induce broadly neutralizing antibodies, identifying new targets and defining new approaches to immunogen evaluation.

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