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Cancer at Nature Research

The Nature Research editors who handle cancer primary research, methods, protocols and reviews bring you the latest articles, covering all aspects from disease mechanisms to therapeutic approaches. Collected here you will also find specially curated content, such as collections, focus issues and animations, all ready to be used in presentations and educational materials. You can also find out about the editors handling cancer contents, and the journals at Nature Research that publish articles on this topic and how to submit to them.

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Research Articles

  • Nature | Article

    The tumour microenvironment determines which type of liver cancer develops, with transformed hepatocytes giving rise to intrahepatic cholangiocarcinoma or hepatocellular carcinoma depending or whether they are surrounded by cells undergoing necroptosis or apoptosis.

    • Marco Seehawer
    • , Florian Heinzmann
    • , Luana D’Artista
    • , Jule Harbig
    • , Pierre-François Roux
    • , Lisa Hoenicke
    • , Hien Dang
    • , Sabrina Klotz
    • , Lucas Robinson
    • , Grégory Doré
    • , Nir Rozenblum
    • , Tae-Won Kang
    • , Rishabh Chawla
    • , Thorsten Buch
    • , Mihael Vucur
    • , Mareike Roth
    • , Johannes Zuber
    • , Tom Luedde
    • , Bence Sipos
    • , Thomas Longerich
    • , Mathias Heikenwälder
    • , Xin Wei Wang
    • , Oliver Bischof
    •  &  Lars Zender
  • Nature Communications | Article | open

    The mechanism underlying the dissemination of diffuse large B-cell lymphoma (DLBCL) is unclear. Here, the authors show that STAT3 controls amoeboid migration in DLBCL via the transcriptional activation of RHOH, which then releases RhoA from RhoGDIγ-mediated suppression, or via regulating microtubule dynamics to activate RhoA.

    • Yi-Ru Pan
    • , Chih-Cheng Chen
    • , Yu-Tien Chan
    • , Hsiao-Jung Wang
    • , Fan-Tso Chien
    • , Yeng-Long Chen
    • , Jing-Lan Liu
    •  &  Muh-Hwa Yang
  • Nature Communications | Article | open

    Pancreatic ductal adenocarcinoma is a lethal human cancer with a poor 5-year overall survival rate. Here the authors perform an exome-wide analysis in a cohort of PDAC patients to identify three novel missense variants in PKN1, DOK2, and APOB genes, that are associated with PDAC risk.

    • Jiang Chang
    • , Jianbo Tian
    • , Ying Zhu
    • , Rong Zhong
    • , Kan Zhai
    • , Jiaoyuan Li
    • , Juntao Ke
    • , QiangQiang Han
    • , Jiao Lou
    • , Wei Chen
    • , Beibei Zhu
    • , Na Shen
    • , Yi Zhang
    • , Yajie Gong
    • , Yang Yang
    • , Danyi Zou
    • , Xiating Peng
    • , Zhi Zhang
    • , Xuemei Zhang
    • , Kun Huang
    • , Ming Yang
    • , Li Wang
    • , Chen Wu
    • , Dongxin Lin
    •  &  Xiaoping Miao
  • Nature Cell Biology | Article

    Barnes et al. report a dynamic and reciprocal crosstalk between tissue tension and glycocalyx bulkiness that promotes a mesenchymal, stem-like phenotype in GBM.

    • J. Matthew Barnes
    • , Shelly Kaushik
    • , Russell O. Bainer
    • , Jason K. Sa
    • , Elliot C. Woods
    • , FuiBoon Kai
    • , Laralynne Przybyla
    • , Mijeong Lee
    • , Hye Won Lee
    • , Jason C. Tung
    • , Ori Maller
    • , Alexander S. Barrett
    • , Kan V. Lu
    • , Jonathon N. Lakins
    • , Kirk C. Hansen
    • , Kirsten Obernier
    • , Arturo Alvarez-Buylla
    • , Gabriele Bergers
    • , Joanna J. Phillips
    • , Do-Hyun Nam
    • , Carolyn R. Bertozzi
    •  &  Valerie M. Weaver
  • Nature Communications | Article | open

    It is known cutaneous squamous cell carcinoma (cSCC) involves a high tumour mutation burden. Here the authors identify common cSCC mutated genes, copy number changes, altered pathways and report the presence of a novel mutation signature associated with chronic exposure to the immunosuppressive drug azathioprine.

    • Gareth J. Inman
    • , Jun Wang
    • , Ai Nagano
    • , Ludmil B. Alexandrov
    • , Karin J. Purdie
    • , Richard G. Taylor
    • , Victoria Sherwood
    • , Jason Thomson
    • , Sarah Hogan
    • , Lindsay C. Spender
    • , Andrew P. South
    • , Michael Stratton
    • , Claude Chelala
    • , Catherine A. Harwood
    • , Charlotte M. Proby
    •  &  Irene M. Leigh
  • Nature Communications | Article | open

    Hofvander and colleagues compare the patterns of clonal evolution in different pathogenetic subgroups of sarcoma. They show that sarcomas driven by gene fusion or amplification display few additional changes over time, whereas sarcomas with complex karyotypes show a gradual increase of nucleotide- and chromosome-level mutations.

    • Jakob Hofvander
    • , Björn Viklund
    • , Anders Isaksson
    • , Otte Brosjö
    • , Fredrik Vult von Steyern
    • , Pehr Rissler
    • , Nils Mandahl
    •  &  Fredrik Mertens

Reviews

  • Nature Reviews Immunology | Review Article

    Eric Vivier and colleagues discuss the emerging roles for natural killer (NK) cells and other innate lymphoid cell populations in cancer immunity. The authors highlight the current immunotherapy trials that are targeting NK cells to treat patients with cancer.

    • Laura Chiossone
    • , Pierre-Yves Dumas
    • , Margaux Vienne
    •  &  Eric Vivier
  • Nature Reviews Clinical Oncology | Review Article

    Improvements in the management of patients with early stage breast cancer have been achieved through intense therapeutic escalation but also with de-escalation of systemic therapies. The authors of this Review summarize key trials using both approaches and highlight the need to use therapeutic escalation for patients who would benefit from that approach and de-escalation for patients with a favourable prognosis.

    • Noam F. Pondé
    • , Dimitrios Zardavas
    •  &  Martine Piccart
  • Nature Reviews Drug Discovery | Review Article

    In this Review, Pastor et al. provide an overview of RNA-based agents used in cancer immunotherapy — ranging from RNA vaccines encoding cancer neoantigens to interference RNAs and protein-binding RNA aptamers — providing insights into this emerging field.

    • Fernando Pastor
    • , Pedro Berraondo
    • , Iñaki Etxeberria
    • , Josh Frederick
    • , Ugur Sahin
    • , Eli Gilboa
    •  &  Ignacio Melero
  • Nature Reviews Cancer | Review Article

    This Review discusses the reprogramming of the urea cycle, the main metabolic liver pathway for nitrogen disposal, in cancer cells. The authors provide insight into the metabolic advantages and therapeutic opportunities stemming from urea cycle enzyme perturbations in cancer.

    • Rom Keshet
    • , Peter Szlosarek
    • , Arkaitz Carracedo
    •  &  Ayelet Erez
  • Nature Reviews Materials | Review Article

    This Review discusses how biomaterials can be used to recreate and understand the influence of specific tumour microenvironment properties on cancer progression and highlights materials-based strategies to capture, detect and assess metastatic cancer cells in vitro and in vivo.

    • Pranjali Beri
    • , Bibiana F. Matte
    • , Laurent Fattet
    • , Daehwan Kim
    • , Jing Yang
    •  &  Adam J. Engler

News & Commentary

  • Nature Reviews Drug Discovery | Comment

    The definition and acceptability of an orphan condition is pivotal for the assessment of European orphan medicinal product designation applications, and consequently the eligibility for incentives. Here, based on the experiences of the Committee for Orphan Medicinal Products, we discuss how to define orphan conditions in the context of the European regulatory framework.

    • Daniel J. O'Connor
    • , Maria E. Sheean
    • , Matthias P. Hofer
    • , Stelios Tsigkos
    • , Segundo Mariz
    • , Laura Fregonese
    • , Kristina Larsson
    • , Virginie Hivert
    • , Kerstin Westermark
    • , Frauke Naumann-Winter
    • , Violeta Stoyanova-Beninska
    • , Ingeborg Barišić
    • , Giuseppe Capovilla
    • , Armando Magrelli
    •  &  Bruno Sepodes
  • Nature Reviews Cancer | Research Highlight

    Lee, Adler et al. show that urea cycle dysregulation is common in cancer and leads to a purine to pyrimidine mutational bias that is associated with a better response to immune checkpoint inhibitors.

    • Sarah Seton-Rogers
  • Nature Biomedical Engineering | News & Views

    A holographic approach relying on small-molecule chromogens enables a rapid and inexpensive test for the accurate classification of aggressive lymphoma at the point of care.

    • Varun L. Kopparthy
    • , Ryan Snodgrass
    •  &  David Erickson
  • Nature Biomedical Engineering | News & Views

    A flexible magnetic wire inserted in a blood vessel improves the capture of magnetically labelled circulating tumour cells.

    • Tae-Hyun Shin
    •  &  Jinwoo Cheon

Methods & Protocols