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Cancer at Nature Research

The Nature Research editors who handle cancer primary research, methods, protocols and reviews bring you the latest articles, covering all aspects from disease mechanisms to therapeutic approaches. Collected here you will also find specially curated content, such as collections, focus issues and animations, all ready to be used in presentations and educational materials. You can also find out about the editors handling cancer content, and the journals at Nature Research that publish articles on this topic and how to submit to them.

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Research Articles

  • Nature Communications | Article | open

    Turning tumour promoting macrophages into an anti-tumour phenotype is an attractive therapeutic strategy. Here, the authors develop a polysaccharide-based structure that mimicks pathogen-associated molecular patterns and, by activating the toll-like receptors on macrophage surface, promotes a safe anti-tumour immune response in mouse models.

    • Yanxian Feng
    • , Ruoyu Mu
    • , Zhenzhen Wang
    • , Panfei Xing
    • , Junfeng Zhang
    • , Lei Dong
    •  &  Chunming Wang
  • Nature Communications | Article | open

    Agonistic 4-1BB antibodies developed for cancer immunotherapy have suffered from either hepatotoxicity or insufficient anti-cancer activity. Here the authors determine the contribution of FcγR binding and agonistic strength to these outcomes, and engineer a 4-1BB antibody with potent anti-tumor effect and no liver toxicity in mice.

    • Xinyue Qi
    • , Fanlin Li
    • , Yi Wu
    • , Chen Cheng
    • , Ping Han
    • , Jieyi Wang
    •  &  Xuanming Yang
  • Communications Biology | Article | open

    Mona Shehata et al. study the effects of metformin, an antidiabetic drug with potential as a breast cancer treatment, in the normal mouse mammary gland. They find that metformin targets hormone receptor positive (HR+) luminal cells and decreases the progenitor capacity of these cells when administered at clinically relevant doses.

    • Mona Shehata
    • , Hyeyeon Kim
    • , Ravi Vellanki
    • , Paul D. Waterhouse
    • , Mathepan Mahendralingam
    • , Alison E. Casey
    • , Marianne Koritzinsky
    •  &  Rama Khokha
  • Nature Communications | Article | open

    Mesenchymal stem cells derived from dental pulp (DP-MSCs) differ in oncogenesic and developmental potential compared to those from bone marrow. Here, the authors show that decreased DNA methylation and histone H3K9Me2 enrichment along with higher PTEN activation in DP-MSCs promotes osteogenesis and reduces oncogenesis.

    • Wen-Ching Shen
    • , Yung-Chih Lai
    • , Ling-Hui Li
    • , Kolin Liao
    • , Hung-Chang Lai
    • , Shou-Yen Kao
    • , John Wang
    • , Cheng-Ming Chuong
    •  &  Shih-Chieh Hung
  • Nature Biomedical Engineering | Article

    The efficiency of delivery of anticancer drugs by microparticles derived from tumour-repopulating cells isolated from 3D fibrin gels is enhanced by the microparticles’ softness.

    • Qingle Liang
    • , Nana Bie
    • , Tuying Yong
    • , Ke Tang
    • , Xiaolong Shi
    • , Zhaohan Wei
    • , Haibo Jia
    • , Xiaoqiong Zhang
    • , Haiyan Zhao
    • , Wei Huang
    • , Lu Gan
    • , Bo Huang
    •  &  Xiangliang Yang

Reviews

  • Nature Reviews Urology | Review Article

    In this Review, the authors discuss the emerging oncogenic roles of long non-coding RNAs in prostate, kidney and bladder cancers, highlighting unique opportunities to improve diagnosis, treatment and precision medicine strategies in these genitourinary malignancies.

    • Ronan Flippot
    • , Guillaume Beinse
    • , Alice Boilève
    • , Julien Vibert
    •  &  Gabriel G. Malouf
  • Nature Reviews Urology | Review Article

    In this Review, Amarasekera and colleagues consider the effect of prostate cancer diagnosis and treatment on men in sexual minority groups, including men who have sex with men and transgender women as well as men with HIV, and discuss how and why efforts to study this population are complicated and evolving.

    • Channa Amarasekera
    • , Vincent Wong
    • , Emily Yura
    • , Adarsh Manjunath
    • , Edward Schaeffer
    •  &  Shilajit Kundu
  • Nature Reviews Cancer | Perspective

    This Opinion article provides an overview of the mechanisms that regulate sensitivity to ferroptosis in cancer cells and how the modulation of metabolic pathways controlling ferroptosis might reshape the tumour niche, leading to an immunosuppressive microenvironment that promotes tumour progression.

    • José Pedro Friedmann Angeli
    • , Dmitri V. Krysko
    •  &  Marcus Conrad
  • Nature Reviews Cancer | Review Article

    Tertiary lymphoid structures (TLSs) form outside of lymphoid tissues at sites of chronic inflammation, including tumours. This Review describes the evidence demonstrating that TLSs are critical for generating antitumour immune responses and are associated with better prognosis in certain cancer types. It also presents potential strategies aimed at inducing TLS neogenesis to improve clinical responses in poorly immunogenic cancers.

    • Catherine Sautès-Fridman
    • , Florent Petitprez
    • , Julien Calderaro
    •  &  Wolf Herman Fridman
  • Nature Reviews Urology | Review Article

    Urinalysis has long been used as a tool for managing diseases, but 21st century techniques have enabled measurement of metabolomic urinary cancer biomarkers using NMR and mass spectrometry. In this Review, the authors discuss the current status of research developments and offer recommendations to help systematize future research in the field.

    • Sarah S. Dinges
    • , Annika Hohm
    • , Lindsey A. Vandergrift
    • , Johannes Nowak
    • , Piet Habbel
    • , Igor A. Kaltashov
    •  &  Leo L. Cheng
  • Nature Reviews Urology | Review Article

    Machine learning (ML) is revolutionizing and reshaping health care, and computer-based systems can be trained to perform complex tasks in bioinformatics, medical imaging and medical robotics. In this Review, Goldenberg et al. consider ML in the management of prostate cancer, with growing applications in diagnostic imaging, surgical interventions, skills training and assessment, digital pathology and genomics.

    • S. Larry Goldenberg
    • , Guy Nir
    •  &  Septimiu E. Salcudean

News & Commentary

Methods & Protocols

  • Nature Protocols | Protocol

    The percentage of cancer neoantigens that are spontaneously recognized by T cells is generally very low. This protocol describes how CD8+ T cells from healthy donors can be used for enhanced targeting of these neoantigens.

    • Muhammad Ali
    • , Zsofia Foldvari
    • , Eirini Giannakopoulou
    • , Maxi-Lu Böschen
    • , Erlend Strønen
    • , Weiwen Yang
    • , Mireille Toebes
    • , Benjamin Schubert
    • , Oliver Kohlbacher
    • , Ton N. Schumacher
    •  &  Johanna Olweus