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The roles and functional mechanisms of interleukin-17 family cytokines in mucosal immunity

Cellular & Molecular Immunology volume 13, pages 418–431 (2016)Cite this article

Abstract

The mucosal immune system serves as our front-line defense against pathogens. It also tightly maintains immune tolerance to self-symbiotic bacteria, which are usually called commensals. Sensing both types of microorganisms is modulated by signalling primarily through various pattern-recognition receptors (PRRs) on barrier epithelial cells or immune cells. After sensing, proinflammatory molecules such as cytokines are released by these cells to mediate either defensive or tolerant responses. The interleukin-17 (IL-17) family members belong to a newly characterized cytokine subset that is critical for the maintenance of mucosal homeostasis. In this review, we will summarize recent progress on the diverse functions and signals of this family of cytokines at different mucosal edges.

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Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (81430036, 81230075, 91429307, 31329002, 91329301 and 91542119), the 973 Program (2013CB944904), and the Science and Technology Commission of Shanghai Municipality (13JC1408900).

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  1. Xinyang Song and Xiao He: These authors contribute equally to the work.

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  1. Shanghai Institute of Rheumatology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200001, China

    Xinyang Song, Xiao He & Youcun Qian

  2. Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

    Xinyang Song & Youcun Qian

  3. Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, 44195, OH, USA

    Xiaoxia Li

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Song, X., He, X., Li, X. et al. The roles and functional mechanisms of interleukin-17 family cytokines in mucosal immunity. Cell Mol Immunol 13, 418–431 (2016). https://doi.org/10.1038/cmi.2015.105

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