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Guiding dengue vaccine development using knowledge gained from the success of the yellow fever vaccine

Cellular & Molecular Immunology volume 13, pages 36–46 (2016)Cite this article

Abstract

Flaviviruses comprise approximately 70 closely related RNA viruses. These include several mosquito-borne pathogens, such as yellow fever virus (YFV), dengue virus (DENV), and Japanese encephalitis virus (JEV), which can cause significant human diseases and thus are of great medical importance. Vaccines against both YFV and JEV have been used successfully in humans for decades; however, the development of a DENV vaccine has encountered considerable obstacles. Here, we review the protective immune responses elicited by the vaccine against YFV to provide some insights into the development of a protective DENV vaccine.

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Acknowledgements

The work was supported in part by a program project grant from the Shanghai Pasteur Health Research Foundation (Y359P41505) to XJ.

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  1. Viral Disease and Vaccine Translational Research Unit, and Vaccine Centre, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China

    Huabin Liang, Min Lee & Xia Jin

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  1. Huabin Liang
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Correspondence to Xia Jin.

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Liang, H., Lee, M. & Jin, X. Guiding dengue vaccine development using knowledge gained from the success of the yellow fever vaccine. Cell Mol Immunol 13, 36–46 (2016). https://doi.org/10.1038/cmi.2015.76

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