ADVANCE ONLINE PUBLICATION
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publication
June 24 2009 |
June 17 2009 |
June 10 2009 |
June 3 2009 |
May 27 2009 |
May 20 2009 |
May 13 2009 |
May 6 2009 |
April 29 2009 |
April 15 2009 |
April 1 2009 |
February 20 2008 |
February 13 2008
July 1 2009
Development
Transporters for Drug Delivery and as Drug Targets in Parasitic Protozoa
S M Landfear
Clin Pharmacol Ther advance online publication, July 1, 2009; doi:10.1038/clpt.2009.116
Articles
Hydrochlorothiazide and Atenolol Combination Antihypertensive Therapy: Effects of Drug Initiation Order
J A Johnson, Y Gong, K R Bailey, R M Cooper-DeHoff, A B Chapman, S T Turner, G L Schwartz, K Campbell, S Schmidt, A L Beitelshees, E Boerwinkle and J G Gums
Clin Pharmacol Ther advance online publication, July 1, 2009; doi:10.1038/clpt.2009.101
Potential Clinical and Economic Outcomes of CYP2C9 and VKORC1 Genotype-Guided Dosing in Patients Starting Warfarin Therapy
J H S You, K K N Tsui, R S M Wong and G Cheng
Clin Pharmacol Ther advance online publication, July 1, 2009; doi:10.1038/clpt.2009.104
Translational Medicine
The Animal Rule and Emerging Infections: The Role of Clinical Pharmacology in Determining an Effective Dose
K L Bergman
Clin Pharmacol Ther advance online publication, July 1, 2009; doi:10.1038/clpt.2009.106
Systematic Evaluation of Drug–Disease Relationships to Identify Leads for Novel Drug Uses
A P Chiang and A J Butte
Clin Pharmacol Ther advance online publication, July 1, 2009; doi:10.1038/clpt.2009.103
Population Analyses of Atorvastatin Clearance in Patients Living in the Community and in Nursing Homes
J B Schwartz and D Verotta
Clin Pharmacol Ther advance online publication, July 1, 2009; doi:10.1038/clpt.2009.100
Clinical Challenges in Addressing Resistance to Antimicrobial Drugs in the Twenty-First Century
E J Septimus and K M Kuper
Clin Pharmacol Ther advance online publication, July 1, 2009; doi:10.1038/clpt.2009.122
June 24 2009
State of the Art
New Antithrombotic Drugs
P L Gross and J I Weitz
Clin Pharmacol Ther advance online publication, June 24, 2009; doi:10.1038/clpt.2009.98
Articles
Utility of Adiponectin as a Biomarker Predictive of Glycemic Efficacy Is Demonstrated by Collaborative Pooling of Data From Clinical Trials Conducted by Multiple Sponsors
J A Wagner, E C Wright, M M Ennis, M Prince, J Kochan, D J R Nunez, B Schneider, M-D Wang, Y Chen, S Ghosh, B J Musser and M T Vassileva
Clin Pharmacol Ther advance online publication, June 24, 2009; doi:10.1038/clpt.2009.88
Translational Medicine
Pharmacological Treatment for Heart Failure: A View From the Brain FREE
R B Felder, Y Yu, Z-H Zhang and S-G Wei
Clin Pharmacol Ther advance online publication, June 24, 2009; doi:10.1038/clpt.2009.117
COX-1 and Vascular Disease
P M Vanhoutte
Clin Pharmacol Ther advance online publication, June 24, 2009; doi:10.1038/clpt.2009.108
June 17 2009
State of the Art
Global Economic and Health Benefits of Tobacco Control: Part 1
H Wipfli and J M Samet
Clin Pharmacol Ther advance online publication, June 17, 2009; doi:10.1038/clpt.2009.93
Global Economic and Health Benefits of Tobacco Control: Part 2
H Wipfli and J M Samet
Clin Pharmacol Ther advance online publication, June 17, 2009; doi:10.1038/clpt.2009.94
Articles
The Effects of Genetic Polymorphisms in the Organic Cation Transporters OCT1, OCT2, and OCT3 on the Renal Clearance of Metformin
M V Tzvetkov, S V Vormfelde, D Balen, I Meineke, T Schmidt, D Sehrt, I Saboli
, H Koepsell and J Brockmöller
Clin Pharmacol Ther advance online publication, June 17, 2009; doi:10.1038/clpt.2009.92
June 10 2009
Articles
A Comprehensive Model for the Humoral Coagulation Network in Humans
T Wajima, G K Isbister and S B Duffull
Clin Pharmacol Ther advance online publication, June 10, 2009; doi:10.1038/clpt.2009.87
Articles
Heart Failure and Adverse Drug Reactions Among Hospitalized Older Adults
C Catananti, R Liperoti, S Settanni, F Lattanzio, R Bernabei, D Fialova, F Landi and G Onder
Clin Pharmacol Ther advance online publication, June 10, 2009; doi:10.1038/clpt.2009.89
Reports
Influence of CYP3A and CYP2C19 Genetic Polymorphisms on the Pharmacokinetics of Cilostazol in Healthy Subjects
H-D Yoo, S-A Park, H-Y Cho and Y-B Lee
Clin Pharmacol Ther advance online publication, June 10, 2009; doi:10.1038/clpt.2009.90
June 3 2009
Articles
Significantly Altered Systemic Exposure to Atorvastatin Acid Following Gastric Bypass Surgery in Morbidly Obese Patients
IB Skottheim, K Stormark, H Christensen, GS Jakobsen, J Hjelmesæth, T Jenssen, JLE Reubsaet, R Sandbu and A Åsberg
Clin Pharmacol Ther advance online publication, June 3, 2009; doi:10.1038/clpt.2009.82
UGT1A9 -275T>A/-2152C>T Polymorphisms Correlate With Low MPA Exposure and Acute Rejection in MMF/Tacrolimus-Treated Kidney Transplant Patients
RHN van Schaik, M van Agteren, JW de Fijter, A Hartmann, J Schmidt, K Budde, D Kuypers, Y Le Meur, M van der Werf, R Mamelok and T van Gelder
Clin Pharmacol Ther advance online publication, June 3, 2009; doi:10.1038/clpt.2009.83
May 27 2009
Articles
ABCG2 Polymorphism Markedly Affects the Pharmacokinetics of Atorvastatin and Rosuvastatin
JE Keskitalo, O Zolk, MF Fromm, KJ Kurkinen, PJ Neuvonen and M Niemi
Clin Pharmacol Ther advance online publication, May 27, 2009; doi:10.1038/clpt.2009.79
The Relationships of ABCB1 3435C>T and CYP2B6 516G>T With High-Density Lipoprotein Cholesterol in HIV-Infected Patients Receiving Efavirenz
TW Mahungu, D Nair, CJ Smith, D Egan, M Youle, MA Johnson, SH Khoo, DJ Back and A Owen
Clin Pharmacol Ther advance online publication, May 27, 2009; doi:10.1038/clpt.2009.78
A Population Pharmacokinetic and Pharmacodynamic Evaluation of Pralatrexate in Patients With Relapsed or Refractory Non-Hodgkin's or Hodgkin's Lymphoma
DR Mould, K Sweeney, SB Duffull, E Neylon, P Hamlin, S Horwitz, F Sirotnak, M Fleisher, ME Saunders and OA O'Connor
Clin Pharmacol Ther advance online publication, May 27, 2009; doi:10.1038/clpt.2009.80
May 20 2009
Articles
Hypertension Induced by Erythropoietin Has a Correlation With Truncated Erythropoietin Receptor mRNA in Endothelial Progenitor Cells of Hemodialysis Patients
T Ioka, S Tsuruoka, C Ito, H Iwaguro, T Asahara, A Fujimura and E Kusano
Clin Pharmacol Ther advance online publication, May 20, 2009; doi:10.1038/clpt.2009.74
Plasma 4
-Hydroxycholesterol: An Endogenous CYP3A Metric?
D Tomalik-Scharte, D Lütjohann, O Doroshyenko, D Frank, A Jetter and U Fuhr
Clin Pharmacol Ther advance online publication, May 20, 2009; doi:10.1038/clpt.2009.72
May 13 2009
Articles
Cannabis Coadministration Potentiates the Effects of "Ecstasy" on Heart Rate and Temperature in Humans
GJ Dumont, C Kramers, FC Sweep, DJ Touw, JG van Hasselt, M de Kam, JM van Gerven, JK Buitelaar and RJ Verkes
Clin Pharmacol Ther advance online publication, May 13, 2009; doi:10.1038/clpt.2009.62
Elucidation of Relationship Between Tumor Size and Survival in Non-Small-Cell Lung Cancer Patients Can Aid Early Decision Making in Clinical Drug Development
Y Wang, C Sung, C Dartois, R Ramchandani, BP Booth, E Rock and J Gobburu
Clin Pharmacol Ther advance online publication, May 13, 2009; doi:10.1038/clpt.2009.64
May 6 2009
Articles
Effect of the Cathepsin K Inhibitor Odanacatib on Bone Resorption Biomarkers in Healthy Postmenopausal Women: Two Double-Blind, Randomized, Placebo-Controlled Phase I Studies
SA Stoch, S Zajic, J Stone, DL Miller, K Van Dyck, MJ Gutierrez, M De Decker, L Liu, Q Liu, BB Scott, D Panebianco, B Jin, LT Duong, K Gottesdiener and JA Wagner
Clin Pharmacol Ther advance online publication, May 6, 2009; doi:10.1038/clpt.2009.60
Letters to the Editor
No Obvious Extra Cardiovascular Risk Associated With Low-Dose NSAIDs
N Moore
Clin Pharmacol Ther advance online publication, May 6, 2009; doi:10.1038/clpt.2009.66
Are Myocardial Infarctions and Death in Healthy Individuals Associated With the Use of Cyclooxygenase Inhibitors?
B Renner and K Brune
Clin Pharmacol Ther advance online publication, May 6, 2009; doi:10.1038/clpt.2009.65
April 29 2009
Reports
Pretransplant Pharmacodynamic Analysis of Immunosuppressive Agents Using CFSE-Based T-Cell Proliferation Assay
Y Kurata, M Kato, T Kuzuya, Y Miwa, K Iwasaki, M Haneda, K Amioka, Y Watarai, K Uchida, A Nakao and T Kobayashi
Clin Pharmacol Ther advance online publication, April 29, 2009; doi:10.1038/clpt.2009.61
April 15 2009
Articles
Generating Genome-Scale Candidate Gene Lists for Pharmacogenomics
NT Hansen, S Brunak and RB Altman
Clin Pharmacol Ther advance online publication, April 15, 2009; doi:10.1038/clpt.2009.42
April 1 2009
Reports
Comparison of Manual and Automated Measurements of the QT Interval in Healthy Volunteers: An Analysis of Five Thorough QT Studies
C Fosser, G Duczynski, M Agin, P Wicker and B Darpo
Clin Pharmacol Ther advance online publication, April 1, 2009; doi:10.1038/clpt.2009.34
February 20 2008
Articles
Effects of Pregnancy on CYP3A and P-glycoprotein Activities as Measured by Disposition of Midazolam and Digoxin: A University of Washington Specialized Center of Research Study
MF Hebert, TR Easterling, B Kirby, DB Carr, ML Buchanan, T Rutherford, KE Thummel, DP Fishbein and JD Unadkat
Clin Pharmacol Ther advance online publication, February 20, 2008; doi:10.1038/sj.clpt.6100514
