ADVANCE ONLINE PUBLICATION
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publication
October 28 2009 |
October 21 2009 |
September 30 2009 |
September 23 2009 |
September 9 2009 |
September 2 2009 |
August 26 2009 |
July 1 2009 |
June 24 2009 |
May 6 2009 |
February 20 2008 |
February 13 2008
November 4 2009
Practice
Transporter Pharmacogenetics and Statin Toxicity
M Niemi
Clin Pharmacol Ther advance online publication, November 4, 2009; doi:10.1038/clpt.2009.197
Comparison of Critical Drug–Drug Interaction Listings: The Department of Veterans Affairs Medical System and Standard Reference Compendia
E L Olvey, S Clauschee and D C Malone
Clin Pharmacol Ther advance online publication, November 4, 2009; doi:10.1038/clpt.2009.198
Articles
The Role of Organic Anion–Transporting Polypeptides and Their Common Genetic Variants in Mycophenolic Acid Pharmacokinetics
N Picard, S W Yee, J-B Woillard, Y Lebranchu, Y Le Meur, K M Giacomini and P Marquet
Clin Pharmacol Ther advance online publication, November 4, 2009; doi:10.1038/clpt.2009.205
Articles
Safety and Pharmacokinetics of Repeat-Dose Micafungin in Young Infants
D K Benjamin Jr, P B Smith, A Arrieta, L Castro, P J Sánchez, D Kaufman, L J Arnold, L L Kovanda, T Sawamoto, D N Buell, W W Hope and T J Walsh
Clin Pharmacol Ther advance online publication, November 4, 2009; doi:10.1038/clpt.2009.200
A Pharmacovigilance Program From Laboratory Signals for the Detection and Reporting of Serious Adverse Drug Reactions in Hospitalized Patients
E Ramirez, A J Carcas, A M Borobia, S H Lei, E Piñana, S Fudio and J Frias
Clin Pharmacol Ther advance online publication, November 4, 2009; doi:10.1038/clpt.2009.185
Ocular Hemodynamic Effects of Nitrovasodilators in Healthy Subjects
D Schmidl, E Polska, B Kiss, S Sacu, G Garhofer and L Schmetterer
Clin Pharmacol Ther advance online publication, November 4, 2009; doi:10.1038/clpt.2009.186
Development
Sustained Neurobehavioral Effects of Exposure to SSRI Antidepressants During Development: Molecular to Clinical Evidence
T F Oberlander, J A Gingrich and M S Ansorge
Clin Pharmacol Ther advance online publication, November 4, 2009; doi:10.1038/clpt.2009.201
October 28 2009
Letters to the Editor
Response to "No Obvious Extra Cardiovascular Risk Associated With Low-Dose NSAIDs," "Do NSAIDs Actually Protect Against Myocardial Infarction and Death?," and "Are Myocardial Infarctions and Death in Healthy Individuals Associated With the Use of Cyclooxygenase Inhibitors?"
E L Fosbøl, G H Gislason, L Køber and C Torp-Pedersen
Clin Pharmacol Ther advance online publication, October 28, 2009; doi:10.1038/clpt.2009.204
Do NSAIDs Actually Protect Against Myocardial Infarction and Death?
E J van Beers, J R de Groot and J G P Tijssen
Clin Pharmacol Ther advance online publication, October 28, 2009; doi:10.1038/clpt.2009.164
Articles
Population Pharmacokinetics and Pharmacogenetics of Tacrolimus in De Novo Pediatric Kidney Transplant Recipients
W Zhao, V Elie, G Roussey, K Brochard, P Niaudet, V Leroy, C Loirat, P Cochat, S Cloarec, J L André, F Garaix, A Bensman, M Fakhoury and E Jacqz-Aigrain
Clin Pharmacol Ther advance online publication, October 28, 2009; doi:10.1038/clpt.2009.210
Development
Developmental Pharmacogenetics: A General Paradigm for Application to Neonatal Pharmacology and Toxicology
J S Leeder
Clin Pharmacol Ther advance online publication, October 28, 2009; doi:10.1038/clpt.2009.195
October 21 2009
Discovery
Clinical Trial Simulations in Pediatric Patients Using Realistic Covariates: Application to Teduglutide, a Glucagon-Like Peptide-2 Analog in Neonates and Infants With Short-Bowel Syndrome
M S Mouksassi, J F Marier, J Cyran and A A Vinks
Clin Pharmacol Ther advance online publication, October 21, 2009; doi:10.1038/clpt.2009.199
September 30 2009
Articles
Genetic Factors (VKORC1, CYP2C9, EPHX1, and CYP4F2) Are Predictor Variables for Warfarin Response in Very Elderly, Frail Inpatients
E Pautas, C Moreau, I Gouin-Thibault, J-L Golmard, I Mahé, C Legendre, E Taillandier-Hériche, B Durand-Gasselin, A-M Houllier, P Verrier, P Beaune, M-A Loriot and V Siguret
Clin Pharmacol Ther advance online publication, September 30, 2009; doi:10.1038/clpt.2009.178
UDP-Glucuronosyltransferase (UGT) Polymorphisms Affect Atorvastatin Lactonization In Vitro and In Vivo
S Riedmaier, K Klein, U Hofmann, J E Keskitalo, P J Neuvonen, M Schwab, M Niemi and U M Zanger
Clin Pharmacol Ther advance online publication, September 30, 2009; doi:10.1038/clpt.2009.181
Loss-of-Function CYP2C9 Variants Improve Therapeutic Response to Sulfonylureas in Type 2 Diabetes: A Go-DARTS Study
K Zhou, L Donnelly, L Burch, R Tavendale, A S F Doney, G Leese, A T Hattersley, M I McCarthy, A D Morris, C C Lang, C N A Palmer and E R Pearson
Clin Pharmacol Ther advance online publication, September 30, 2009; doi:10.1038/clpt.2009.176
September 23 2009
Reports
Genetic Influences on the Pharmacokinetics of Orally and Intravenously Administered Digoxin as Exhibited by Monozygotic Twins
A L Birkenfeld, J Jordan, U Hofmann, A Busjahn, G Franke, N Krüger, S Igel, T Mürdter, S Drescher, S Shi, S Engeli, M Schwab, M Eichelbaum, F C Luft and M F Fromm
Clin Pharmacol Ther advance online publication, September 23, 2009; doi:10.1038/clpt.2009.170
Articles
Pharmacokinetics of Sulfadoxine and Pyrimethamine in Intermittent Preventive Treatment of Malaria in Pregnancy
M M Nyunt, I Adam, K Kayentao, J van Dijk, P Thuma, K Mauff, F Little, Y Cassam, E Guirou, B Traore, O Doumbo, D Sullivan, P Smith and K I Barnes
Clin Pharmacol Ther advance online publication, September 23, 2009; doi:10.1038/clpt.2009.177
September 9 2009
Articles
Potent and Selective Agonism of the Melanocortin Receptor 4 With MK-0493 Does Not Induce Weight Loss in Obese Human Subjects: Energy Intake Predicts Lack of Weight Loss Efficacy
R Krishna, B Gumbiner, C Stevens, B Musser, M Mallick, S Suryawanshi, L Maganti, H Zhu, T H Han, L Scherer, B Simpson, D Cosgrove, K Gottesdiener, J Amatruda, B J Rolls, J Blundell, G A Bray, K Fujioka, S B Heymsfield, J A Wagner and G A Herman
Clin Pharmacol Ther advance online publication, September 9, 2009; doi:10.1038/clpt.2009.167
Comparison of Native E. coli and PEG Asparaginase Pharmacokinetics and Pharmacodynamics in Pediatric Acute Lymphoblastic Leukemia
J C Panetta, A Gajjar, N Hijiya, L J Hak, C Cheng, W Liu, C H Pui and M V Relling
Clin Pharmacol Ther advance online publication, September 9, 2009; doi:10.1038/clpt.2009.162
September 2 2009
Letters to the Editor
Rupatadine and Heart Rhythm Disturbances
R Fité and J Borja
Clin Pharmacol Ther advance online publication, September 2, 2009; doi:10.1038/clpt.2009.118
Letters to the Editor
Response to "Rupatadine and Heart Rhythm Disturbances"
A Carvajal, D Macías, I Salado, M Sáinz, S Ortega, C Campo, J García del Pozo, L H Martín Arias, A Velasco, S Gonçalves, R Pombal and R Carmona
Clin Pharmacol Ther advance online publication, September 2, 2009; doi:10.1038/clpt.2009.157
Articles
Orally Administered Glucagon-Like Peptide-1 Affects Glucose Homeostasis Following an Oral Glucose Tolerance Test in Healthy Male Subjects
R E Steinert, B Poller, M C Castelli, K Friedman, A R Huber, J Drewe and C Beglinger
Clin Pharmacol Ther advance online publication, September 2, 2009; doi:10.1038/clpt.2009.159
August 26 2009
Articles
Escitalopram Is a Weak Inhibitor of the CYP2D6-Catalyzed O-Demethylation of (+)-Tramadol but Does Not Reduce the Hypoalgesic Effect in Experimental Pain
L Noehr-Jensen, S T Zwisler, F Larsen, S H Sindrup, P Damkier and K Brosen
Clin Pharmacol Ther advance online publication, August 26, 2009; doi:10.1038/clpt.2009.154
Risk to the Breast-Fed Neonate From Codeine Treatment to the Mother: A Quantitative Mechanistic Modeling Study
S Willmann, A N Edginton, K Coboeken, G Ahr and J Lippert
Clin Pharmacol Ther advance online publication, August 26, 2009; doi:10.1038/clpt.2009.151
July 1 2009
Development
Transporters for Drug Delivery and as Drug Targets in Parasitic Protozoa
S M Landfear
Clin Pharmacol Ther advance online publication, July 1, 2009; doi:10.1038/clpt.2009.116
June 24 2009
Articles
Utility of Adiponectin as a Biomarker Predictive of Glycemic Efficacy Is Demonstrated by Collaborative Pooling of Data From Clinical Trials Conducted by Multiple Sponsors
J A Wagner, E C Wright, M M Ennis, M Prince, J Kochan, D J R Nunez, B Schneider, M-D Wang, Y Chen, S Ghosh, B J Musser and M T Vassileva
Clin Pharmacol Ther advance online publication, June 24, 2009; doi:10.1038/clpt.2009.88
May 6 2009
Letters to the Editor
No Obvious Extra Cardiovascular Risk Associated With Low-Dose NSAIDs
N Moore
Clin Pharmacol Ther advance online publication, May 6, 2009; doi:10.1038/clpt.2009.66
Are Myocardial Infarctions and Death in Healthy Individuals Associated With the Use of Cyclooxygenase Inhibitors?
B Renner and K Brune
Clin Pharmacol Ther advance online publication, May 6, 2009; doi:10.1038/clpt.2009.65
February 20 2008
Articles
Effects of Pregnancy on CYP3A and P-glycoprotein Activities as Measured by Disposition of Midazolam and Digoxin: A University of Washington Specialized Center of Research Study
MF Hebert, TR Easterling, B Kirby, DB Carr, ML Buchanan, T Rutherford, KE Thummel, DP Fishbein and JD Unadkat
Clin Pharmacol Ther advance online publication, February 20, 2008; doi:10.1038/sj.clpt.6100514
