TABLE OF CONTENTS
Volume 86, Issue 6 (December 2009)
Editorial |
News & Views |
Perspectives |
Research |
Discovery & Development |
Erratum & Corrigendum
In This Issue
In This Issue
In This Issue FREE
Clin Pharmacol Ther 86: 571; doi:10.1038/clpt.2009.229
See also: Opinion by Zlotnik Shaul & VitaleSee also: Article by Willmann et al. See also: Article by Panetta et al. See also: Article by LeederEditorial
Editorial
Neonatal Pharmacology: Rational Therapeutics for the Most Vulnerable
L James and S Ito
Clin Pharmacol Ther 86: 573-577; doi:10.1038/clpt.2009.212
News & Views
Highlights
Highlights
Clin Pharmacol Ther 86: 578-579; doi:10.1038/clpt.2009.230
ASCPT News
ASCPT News
Clin Pharmacol Ther 86: 580-582; doi:10.1038/clpt.2009.220
Books
Pediatric Drug Development: Concepts and Applications
Reviewed by S M MacLeod
Clin Pharmacol Ther 86: 583-584; doi:10.1038/clpt.2009.192
Perspectives
Opinion
Clinical Trials in Neonates: A Therapeutic Imperative FREE
R M Ward and S E Kern
Clin Pharmacol Ther 86: 585-587; doi:10.1038/clpt.2009.207
Can We Afford It?: Ethical Consideration of Expensive Drug Treatment for Neonates and Infants FREE
R Zlotnik Shaul and D Vitale
Clin Pharmacol Ther 86: 587-589; doi:10.1038/clpt.2009.211
Clinical Trial Design in Neonatal Pharmacology: Effect of Center Differences, With Lessons From the Pediatric Oncology Cooperative Research Experience FREE
C Moran, P B Smith, M Cohen-Wolkowiez and D K Benjamin Jr
Clin Pharmacol Ther 86: 589-591; doi:10.1038/clpt.2009.175
Commentaries
The Road From Discovery to Clinic: Adiponectin as a Biomarker of Metabolic Status
C M Kusminski and P E Scherer
Clin Pharmacol Ther 86: 592-595; doi:10.1038/clpt.2009.155
See also: Article by Wagner et al.Current Understanding of the Pharmacogenomics of Metformin
O Zolk
Clin Pharmacol Ther 86: 595-598; doi:10.1038/clpt.2009.144
See also: Books by MacLeodLetters to the Editor
Are Myocardial Infarctions and Death in Healthy Individuals Associated With the Use of Cyclooxygenase Inhibitors?
B Renner and K Brune
Clin Pharmacol Ther 86: 599-600; advance online publication, May 6, 2009; doi:10.1038/clpt.2009.65
See also: Letter to the Editor by MooreSee also: Letter to the Editor by van Beers et al. See also: Letter to the Editor by Fosbøl et al.No Obvious Extra Cardiovascular Risk Associated With Low-Dose NSAIDs
N Moore
Clin Pharmacol Ther 86: 600-601; advance online publication, May 6, 2009; doi:10.1038/clpt.2009.66
See also: Letter to the Editor by Renner & BruneSee also: Letter to the Editor by van Beers et al. See also: Letter to the Editor by Fosbøl et al.Do NSAIDs Actually Protect Against Myocardial Infarction and Death?
E J van Beers, J R de Groot and J G P Tijssen
Clin Pharmacol Ther 86: 601-602; advance online publication, October 28, 2009; doi:10.1038/clpt.2009.164
See also: Letter to the Editor by Renner & BruneSee also: Letter to the Editor by MooreSee also: Letter to the Editor by Fosbøl et al.Response to "No Obvious Extra Cardiovascular Risk Associated With Low-Dose NSAIDs," "Do NSAIDs Actually Protect Against Myocardial Infarction and Death?," and "Are Myocardial Infarctions and Death in Healthy Individuals Associated With the Use of Cyclooxygenase Inhibitors?"
E L Fosbøl, G H Gislason, L Køber and C Torp-Pedersen
Clin Pharmacol Ther 86: 602-604; advance online publication, October 28, 2009; doi:10.1038/clpt.2009.204
See also: Letter to the Editor by Renner & BruneSee also: Letter to the Editor by MooreSee also: Letter to the Editor by van Beers et al.Research
Report
Genetic Influences on the Pharmacokinetics of Orally and Intravenously Administered Digoxin as Exhibited by Monozygotic Twins
A L Birkenfeld, J Jordan, U Hofmann, A Busjahn, G Franke, N Krüger, S Igel, T Mürdter, S Drescher, S Shi, S Engeli, M Schwab, M Eichelbaum, F C Luft and M F Fromm
Clin Pharmacol Ther 86: 605-608; advance online publication, September 23, 2009; doi:10.1038/clpt.2009.170
Articles
Population Pharmacokinetics and Pharmacogenetics of Tacrolimus in De Novo Pediatric Kidney Transplant Recipients
W Zhao, V Elie, G Roussey, K Brochard, P Niaudet, V Leroy, C Loirat, P Cochat, S Cloarec, J L André, F Garaix, A Bensman, M Fakhoury and E Jacqz-Aigrain
Clin Pharmacol Ther 86: 609-618; advance online publication, October 28, 2009; doi:10.1038/clpt.2009.210
Utility of Adiponectin as a Biomarker Predictive of Glycemic Efficacy Is Demonstrated by Collaborative Pooling of Data From Clinical Trials Conducted by Multiple Sponsors
J A Wagner, E C Wright, M M Ennis, M Prince, J Kochan, D J R Nunez, B Schneider, M-D Wang, Y Chen, S Ghosh, B J Musser and M T Vassileva
Clin Pharmacol Ther 86: 619-625; advance online publication, June 24, 2009; doi:10.1038/clpt.2009.88
Abstract | Full Text | PDF | Supplementary information
See also: Commentary by Kusminski & SchererEscitalopram Is a Weak Inhibitor of the CYP2D6-Catalyzed O-Demethylation of (+)-Tramadol but Does Not Reduce the Hypoalgesic Effect in Experimental Pain
L Noehr-Jensen, S T Zwisler, F Larsen, S H Sindrup, P Damkier and K Brosen
Clin Pharmacol Ther 86: 626-633; advance online publication, August 26, 2009; doi:10.1038/clpt.2009.154
Risk to the Breast-Fed Neonate From Codeine Treatment to the Mother: A Quantitative Mechanistic Modeling Study FREE
S Willmann, A N Edginton, K Coboeken, G Ahr and J Lippert
Clin Pharmacol Ther 86: 634-643; advance online publication, August 26, 2009; doi:10.1038/clpt.2009.151
Orally Administered Glucagon-Like Peptide-1 Affects Glucose Homeostasis Following an Oral Glucose Tolerance Test in Healthy Male Subjects
R E Steinert, B Poller, M C Castelli, K Friedman, A R Huber, J Drewe and C Beglinger
Clin Pharmacol Ther 86: 644-650; advance online publication, September 2, 2009; doi:10.1038/clpt.2009.159
Comparison of Native E. coli and PEG Asparaginase Pharmacokinetics and Pharmacodynamics in Pediatric Acute Lymphoblastic Leukemia FREE
J C Panetta, A Gajjar, N Hijiya, L J Hak, C Cheng, W Liu, C H Pui and M V Relling
Clin Pharmacol Ther 86: 651-658; advance online publication, September 9, 2009; doi:10.1038/clpt.2009.162
Potent and Selective Agonism of the Melanocortin Receptor 4 With MK-0493 Does Not Induce Weight Loss in Obese Human Subjects: Energy Intake Predicts Lack of Weight Loss Efficacy
R Krishna, B Gumbiner, C Stevens, B Musser, M Mallick, S Suryawanshi, L Maganti, H Zhu, T H Han, L Scherer, B Simpson, D Cosgrove, K Gottesdiener, J Amatruda, B J Rolls, J Blundell, G A Bray, K Fujioka, S B Heymsfield, J A Wagner and G A Herman
Clin Pharmacol Ther 86: 659-666; advance online publication, September 9, 2009; doi:10.1038/clpt.2009.167
Discovery & Development
Discovery
Clinical Trial Simulations in Pediatric Patients Using Realistic Covariates: Application to Teduglutide, a Glucagon-Like Peptide-2 Analog in Neonates and Infants With Short-Bowel Syndrome
M S Mouksassi, J F Marier, J Cyran and A A Vinks
Clin Pharmacol Ther 86: 667-671; advance online publication, October 21, 2009; doi:10.1038/clpt.2009.199
Development
Sustained Neurobehavioral Effects of Exposure to SSRI Antidepressants During Development: Molecular to Clinical Evidence
T F Oberlander, J A Gingrich and M S Ansorge
Clin Pharmacol Ther 86: 672-677; advance online publication, November 4, 2009; doi:10.1038/clpt.2009.201
Developmental Pharmacogenetics: A General Paradigm for Application to Neonatal Pharmacology and Toxicology FREE
J S Leeder
Clin Pharmacol Ther 86: 678-682; advance online publication, October 28, 2009; doi:10.1038/clpt.2009.195
Erratum & Corrigendum
Erratum & Corrigendum
ERRATUM: The Role of Ethnicity in Variability in Response to Drugs: Focus on Clinical Pharmacology Studies
Clin Pharmacol Ther 86: 683; doi:10.1038/clpt.2009.174
