Heart Failure and Adverse Drug Reactions Among Hospitalized Older Adults

doi:doi:10.1038/clpt.2009.89

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Clinical Pharmacology & Therapeutics (2009); 86 3, 307–310. doi:10.1038/clpt.2009.89

Heart Failure and Adverse Drug Reactions Among Hospitalized Older Adults

C Catananti¹, R Liperoti¹, S Settanni¹, F Lattanzio², R Bernabei¹, D Fialova³, F Landi¹ and G Onder¹

¹Department of Geriatrics, Centro Medicina dell'Invecchiamento, Università Cattolica del Sacro Cuore, Rome, Italy
²Research Department, Italian National Research Centre on Aging, Ancona, Italy
³Department of Geriatrics and Gerontology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

Correspondence: G Onder, (graziano_onder@rm.unicatt.it)

Received 2 April 2009; Accepted 14 April 2009; Published online 10 June 2009.

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Abstract

The aim of this study was to assess whether heart failure (HF) could be a risk factor for adverse drug reactions (ADRs) among hospitalized older adults. This study included 19,496 patients admitted to community- and university-based hospitals in Italy (mean age 70 plusminus 14 years; 49.7% female). ADRs were identified in 207 of the 2,413 (8.6%) patients with HF and in 855 (5.0%) of the 17,083 patients without HF (P < 0.001). After adjusting for potential confounders, HF was shown to be associated with an increased likelihood of experiencing an ADR (odds ratio (OR) 1.29; 95% confidence interval (CI) 1.06–1.56). After stratifying the sample by gender, the association continued to be seen in the women (OR 1.58; 95% CI 1.22–2.05) but not in the men (OR 0.99; 95% CI 0.74–1.34). In conclusion, HF appears to be associated with a higher rate of ADRs among hospitalized patients. Gender may influence the effect of HF on the risk of ADRs.