Genes vs. Environment
TABLE OF CONTENTS
Volume 85, Issue 4 (April 2009)
Editorial |
News & Views |
Perspectives |
State of the Art |
Research |
Discovery & Development |
Regulation & Use |
Corrigendum
In This Issue
In This Issue
In This Issue
Clin Pharmacol Ther 85: 341; doi:10.1038/clpt.2009.20
See also: Point/Counterpoint by HumphreysSee also: Point/Counterpoint by Bevilacqua & GoldmanSee also: State of the Art by Brass et al. See also: Article by McConn et al. See also: Article by Friberg et al. See also: Article by Gomez & Ingelman-SundbergEditorial
Editorial
Pharmacogenetics of Pharmacoecology: Which Route to Personalized Medicine?
GR Robertson, DM Grant and M Piquette-Miller
Clin Pharmacol Ther 85: 343-348; doi:10.1038/clpt.2009.17
News & Views
Highlights
Highlights
Clin Pharmacol Ther 85: 350-351; doi:10.1038/clpt.2009.21
ASCPT News
ASCPT News
Clin Pharmacol Ther 85: 352-354; doi:10.1038/clpt.2009.22
Books
Clinical Pharmacology and Therapeutics: Questions for Self Assessment, 3rd Edition
Reviewed by BA Levey
Clin Pharmacol Ther 85: 354-355; doi:10.1038/clpt.2008.257
Perspectives
Point/Counterpoint
Searching Where the Light Is Worse: Overemphasizing Genes and Underplaying Environment in the Quest to Reduce Substance Misuse
K Humphreys
Clin Pharmacol Ther 85: 357-358; doi:10.1038/clpt.2008.263
See also: Point/Counterpoint by Bevilacqua & GoldmanGenes and Addictions
L Bevilacqua and D Goldman
Clin Pharmacol Ther 85: 359-361; doi:10.1038/clpt.2009.6
See also: Point/Counterpoint by HumphreysCommentaries
Stimulation of Cholecystokinin-A Receptors With Gl181771X: A Failed Clinical Trial That Did Not Test the Pharmacogenetic Hypothesis for Reduction of Food Intake
AD Roses
Clin Pharmacol Ther 85: 362-365; doi:10.1038/clpt.2008.192
Evaluating QTc in Patients With Advanced Parkinson's Disease: Overcoming Artifact
DM Bloomfield
Clin Pharmacol Ther 85: 365-366; doi:10.1038/clpt.2008.153
The Dutch Vision of Clinical Pharmacology
JHM Schellens, R Grouls, HJ Guchelaar, DJ Touw, GA Rongen, A de Boer and LM Van Bortel
Clin Pharmacol Ther 85: 366-368; doi:10.1038/clpt.2008.148
State of the Art
State of the Art
Analysis of Multiple End Points in Consumer Research in Support of Switching Drugs From Prescription to Over-the-Counter Status: The Concept of End-Point Hierarchies
EP Brass, LE Shay and A Leonard-Segal
Clin Pharmacol Ther 85: 369-374; advance online publication, January 14, 2009; doi:10.1038/clpt.2008.254
Research
Report
Impact of Different Low-Dose Ritonavir Regimens on Lipids, CD36, and Adipophilin Expression
S Collot-Teixeira, F De Lorenzo, L Waters, C Fletcher, D Back, S Mandalia, A Pozniak, S Yilmaz, JL McGregor, B Gazzard and M Boffito
Clin Pharmacol Ther 85: 375-378; advance online publication, December 31, 2008; doi:10.1038/clpt.2008.243
Articles
Genotypes Associated With Reduced Activity of VKORC1 and CYP2C9 and Their Modification of Acenocoumarol Anticoagulation During the Initial Treatment Period
M Teichert, RHN van Schaik, A Hofman, AG Uitterlinden, PAGM de Smet, BHCh Stricker and LE Visser
Clin Pharmacol Ther 85: 379-386; advance online publication, February 18, 2009; doi:10.1038/clpt.2008.294
Reduced Duodenal Cytochrome P450 3A Protein Expression and Catalytic Activity in Patients With Cirrhosis
DJ McConn II, YS Lin, TL Mathisen, DK Blough, Y Xu, T Hashizume, SL Taylor, KE Thummel and MC Shuhart
Clin Pharmacol Ther 85: 387-393; advance online publication, February 11, 2009; doi:10.1038/clpt.2008.292
Abacavir Pharmacokinetics During Chronic Therapy in HIV-1-Infected Adolescents and Young Adults
JW Sleasman, BL Robbins, SJ Cross, JC Lindsey, JM Kraimer, BE Heckman, HL Sprenger, NB Tustin, CH Rose, PA Poston, EF Neal, GE Pakes, M Nikanjam and EV Capparelli
Clin Pharmacol Ther 85: 394-401; advance online publication, December 31, 2008; doi:10.1038/clpt.2008.236
A Low Dose of Ritonavir-Boosted Atazanavir Provides Adequate Pharmacokinetic Parameters in HIV-1-Infected Thai Adults
A Avihingsanon, J van der Lugt, SJ Kerr, M Gorowara, S Chanmano, P Ohata, J Lange, DA Cooper, P Phanuphak, DM Burger and K Ruxrungtham
Clin Pharmacol Ther 85: 402-408; advance online publication, December 31, 2008; doi:10.1038/clpt.2008.244
An Agonist–Antagonist Interaction Model for Prolactin Release Following Risperidone and Paliperidone Treatment
LE Friberg, AM Vermeulen, KJF Petersson and MO Karlsson
Clin Pharmacol Ther 85: 409-417; advance online publication, December 24, 2008; doi:10.1038/clpt.2008.234
A Dynamic Model of Hand-and-Foot Syndrome in Patients Receiving Capecitabine
E Hénin, B You, E VanCutsem, PM Hoff, J Cassidy, C Twelves, KP Zuideveld, F Sirzen, C Dartois, G Freyer, M Tod and P Girard
Clin Pharmacol Ther 85: 418-425; advance online publication, December 10, 2008; doi:10.1038/clpt.2008.220
Discovery & Development
Discovery
Pharmacoepigenetics: Its Role in Interindividual Differences in Drug Response
A Gomez and M Ingelman-Sundberg
Clin Pharmacol Ther 85: 426-430; advance online publication, February 25, 2009; doi:10.1038/clpt.2009.2
Translational Medicine
Variability in Response to Medicines in Older People: Phenotypic and Genotypic Factors
AJ McLachlan, SN Hilmer and DG Le Couteur
Clin Pharmacol Ther 85: 431-433; advance online publication, February 18, 2009; doi:10.1038/clpt.2009.1
Development
Impact of Infectious and Inflammatory Disease on Cytochrome P450–Mediated Drug Metabolism and Pharmacokinetics
ET Morgan
Clin Pharmacol Ther 85: 434-438; advance online publication, February 11, 2009; doi:10.1038/clpt.2008.302
Regulation & Use
Practice
Effects of Dietary Factors on Drug Transport and Metabolism: The Impact on Dosage Guidelines in Transplant Patients
R Nowack, J Andrassy, M Fischereder and M Unger
Clin Pharmacol Ther 85: 439-443; advance online publication, February 18, 2009; doi:10.1038/clpt.2008.303
Public Policy
Adulteration of Drugs and Foods: Compendial Approaches to Lowering Risk
DR Abernethy, C Sheehan, JC Griffiths and RL Williams for the United States Pharmacopeial Convention Council of Experts Excipients and Food Ingredient Expert Committees
Clin Pharmacol Ther 85: 444-447; advance online publication, May 7, 2008; doi:10.1038/clpt.2008.88
