Highlights

Highlights

Clin Pharmacol Ther 85: 118-119; doi:10.1038/clpt.2008.267

Abstract | Full Text | PDF

ASCPT News

ASCPT News

Clin Pharmacol Ther 85: 120-123; doi:10.1038/clpt.2008.265

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Books

Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response

Reviewed by ER Gardner and WD Figg

Clin Pharmacol Ther 85: 124-125; doi:10.1038/clpt.2008.260

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A Textbook of Clinical Pharmacology and Therapeutics, 5th Edition

Reviewed by J Gray

Clin Pharmacol Ther 85: 125-126; doi:10.1038/clpt.2008.233

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Point/Counterpoint

From Darkness to Light With Biomarkers in Early Clinical Trials of Cancer Drugs

CP Carden, U Banerji, SB Kaye, P Workman and JS de Bono

Clin Pharmacol Ther 85: 131-133; doi:10.1038/clpt.2008.223

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Biomarkers in Early Cancer Drug Development: Limited Utility

RH Glassman and MJ Ratain

Clin Pharmacol Ther 85: 134-135; doi:10.1038/clpt.2008.231

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Opinion

The Price of Success: Cost-Effectiveness of Molecularly Targeted Agents

S Sleijfer and J Verweij

Clin Pharmacol Ther 85: 136-138; doi:10.1038/clpt.2008.245

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Commentary

The Increasing Complexity of Mercaptopurine Pharmacogenomics

S Marsh and DJ Van Booven

Clin Pharmacol Ther 85: 139-141; doi:10.1038/clpt.2008.219

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Letters to the Editor

Personalized Pharmacotherapy: Genotypes, Biomarkers, and Beyond

D Gurwitz and JE Lunshof

Clin Pharmacol Ther 85: 142; advance online publication, November 12, 2008; doi:10.1038/clpt.2008.228

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Declining Public Health Burden of Digoxin Toxicity: Decreased Use or Safer Prescribing?

S Schmiedl, M Rottenkolber, J Szymanski, J Hasford and PA Thuermann

Clin Pharmacol Ther 85: 143-144; advance online publication, December 24, 2008; doi:10.1038/clpt.2008.252

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Report

Vascular Effects of RWJ-676070, a Selective Combined V_1a/V₂ Vasopressin Receptor Antagonist

L Coltamai, M Bucher, MP Maillard, U Shukla, N Bohidar, L Haskell, K Bertelsen, M Fedgchin, B Vogt and M Burnier

Clin Pharmacol Ther 85: 145-148; advance online publication, November 5, 2008; doi:10.1038/clpt.2008.217

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Articles

Phase I/II Pharmacokinetic and Pharmacogenomic Study of UGT1A1 Polymorphism in Elderly Patients With Advanced Non–Small Cell Lung Cancer Treated With Irinotecan

N Yamamoto, T Takahashi, H Kunikane, N Masuda, K Eguchi, M Shibuya, Y Takeda, H Isobe, T Ogura, A Yokoyama and K Watanabe

Clin Pharmacol Ther 85: 149-154; advance online publication, August 6, 2008; doi:10.1038/clpt.2008.152

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Pharmacogenetic Pathway Analysis of Docetaxel Elimination

SD Baker, J Verweij, GA Cusatis, RH van Schaik, S Marsh, SJ Orwick, RM Franke, S Hu, EG Schuetz, V Lamba, WA Messersmith, AC Wolff, MA Carducci and A Sparreboom

Clin Pharmacol Ther 85: 155-163; advance online publication, May 28, 2008; doi:10.1038/clpt.2008.95

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Genetic Polymorphism of Inosine Triphosphate Pyrophosphatase Is a Determinant of Mercaptopurine Metabolism and Toxicity During Treatment for Acute Lymphoblastic Leukemia

G Stocco, MH Cheok, KR Crews, T Dervieux, D French, D Pei, W Yang, C Cheng, C-H Pui, MV Relling and WE Evans

Clin Pharmacol Ther 85: 164-172; advance online publication, August 6, 2008; doi:10.1038/clpt.2008.154

Abstract | Full Text | PDF | Supplementary information

Drug–Drug Interactions Mediated Through P-Glycoprotein: Clinical Relevance and In Vitro–In Vivo Correlation Using Digoxin as a Probe Drug

KS Fenner, MD Troutman, S Kempshall, JA Cook, JA Ware, DA Smith and CA Lee

Clin Pharmacol Ther 85: 173-181; advance online publication, November 5, 2008; doi:10.1038/clpt.2008.195

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Population Pharmacokinetics of Tenofovir in HIV-1-Infected Pregnant Women and Their Neonates (ANRS 12109)

D Hirt, S Urien, DK Ekouévi, E Rey, E Arrivé, S Blanche, C Amani-Bosse, E Nerrienet, G Gray, M Kone, SK Leang, J McIntyre, F Dabis and J-M Tréluyer

Clin Pharmacol Ther 85: 182-189; advance online publication, November 5, 2008; doi:10.1038/clpt.2008.201

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Risk of Myocardial Infarction and Death Associated With the Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Among Healthy Individuals: A Nationwide Cohort Study

EL Fosbøl, GH Gislason, S Jacobsen, F Folke, ML Hansen, TK Schramm, R Sørensen, JN Rasmussen, SS Andersen, SZ Abildstrom, J Trærup, HE Poulsen, S Rasmussen, L Køber and C Torp-Pedersen

Clin Pharmacol Ther 85: 190-197; advance online publication, November 5, 2008; doi:10.1038/clpt.2008.204

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Discovery

Phase 0 Clinical Studies in Oncology

JM Collins

Clin Pharmacol Ther 85: 204-207; advance online publication, December 24, 2008; doi:10.1038/clpt.2008.246

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Translational Medicine

Pharmacokinetic Considerations for New Targeted Therapies

SD Baker and S Hu

Clin Pharmacol Ther 85: 208-211; advance online publication, December 17, 2008; doi:10.1038/clpt.2008.242

Abstract | Full Text | PDF