Adolescence

TABLE OF CONTENTS

Volume 84, Issue 6 (December 2008)

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In This Issue

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Editorial

Editorial

Adolescent Pharmacology: A Pertinent Issue of Medicine as Opposed to Medicines

GL Kearns and M Spaulding-Barclay

Clin Pharmacol Ther 84: 639-644; doi:10.1038/clpt.2008.206

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News & Views

Highlights

Highlights

Clin Pharmacol Ther 84: 646-647; doi:10.1038/clpt.2008.226

ASCPT News

ASCPT News

Clin Pharmacol Ther 84: 648-652; doi:10.1038/clpt.2008.227

Books

Adolescent Health in the United States, 2007

Reviewed by ML Dreyer

Clin Pharmacol Ther 84: 653-654; doi:10.1038/clpt.2008.207

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Perspectives

Commentary

Adolescents in Clinical Trials

BG Kapogiannis and DR Mattison

Clin Pharmacol Ther 84: 655-659; doi:10.1038/clpt.2008.191

Letters to the Editor

Lack of Evidence for an Effect of Lopinavir/Ritonavir on Tenofovir Renal Clearance

AS Ray, MR Wright and GR Rhodes

Clin Pharmacol Ther 84: 660; advance online publication, July 9, 2008; doi:10.1038/clpt.2008.140

See also: Letters to the Editor by Kiser & Fletcher
Response to "Lack of Evidence for an Effect of Lopinavir/Ritonavir on Tenofovir Renal Clearance"

JJ Kiser and CV Fletcher

Clin Pharmacol Ther 84: 661; advance online publication, August 27, 2008; doi:10.1038/clpt.2008.169

See also: Letters to the Editor by Ray et al.
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State of the Art

State of the Art

Hormonal Regulation of Hepatic Drug-Metabolizing Enzyme Activity During Adolescence FREE

MJ Kennedy

Clin Pharmacol Ther 84: 662-673; advance online publication, October 29, 2008; doi:10.1038/clpt.2008.202

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Research

Reports

Reduced Activities of Cytochrome P450 1A2 and Xanthine Oxidase in Children With Growth Hormone Deficiency

MJ Kennedy, DA Davis, N Smith, A Gaedigk, RE Pearce and GL Kearns

Clin Pharmacol Ther 84: 674-678; advance online publication, October 8, 2008; doi:10.1038/clpt.2008.185

Multiple-Dose Pharmacodynamics and Pharmacokinetics of Anacetrapib, a Potent Cholesteryl Ester Transfer Protein (CETP) Inhibitor, in Healthy Subjects

R Krishna, AJ Bergman, B Jin, M Fallon, J Cote, P Van Hoydonck, T Laethem, IN Gendrano III, K Van Dyck, D Hilliard, O Laterza, K Snyder, C Chavez-Eng, R Lutz, J Chen, DM Bloomfield, M De Smet, LM Van Bortel, M Gutierrez, N Al-Huniti, K Dykstra, KM Gottesdiener and JA Wagner

Clin Pharmacol Ther 84: 679-683; advance online publication, June 25, 2008; doi:10.1038/clpt.2008.109

Articles

Acetaminophen-Associated Hepatic Injury: Evaluation of Acetaminophen Protein Adducts in Children and Adolescents With Acetaminophen Overdose FREE

LP James, EV Capparelli, PM Simpson, L Letzig, D Roberts, JA Hinson, GL Kearns, JL Blumer and JE Sullivan ;The Network of Pediatric Pharmacology Research Units, National Institutes of Child Health and Human Development

Clin Pharmacol Ther 84: 684-690; advance online publication, October 15, 2008; doi:10.1038/clpt.2008.190

Etoposide Sensitivity Does Not Predict MLL Rearrangements or Risk of Therapy-Related Acute Myeloid Leukemia

J Yang, A Bogni, C Cheng, WK Bleibel, X Cai, Y Fan, W Yang, JCC Rocha, D Pei, W Liu, ME Dolan, C-H Pui and MV Relling

Clin Pharmacol Ther 84: 691-697; advance online publication, May 28, 2008; doi:10.1038/clpt.2008.86

The Effect of Atazanavir and Atazanavir/Ritonavir on UDP-Glucuronosyltransferase Using Lamotrigine as a Phenotypic Probe

DM Burger, A Huisman, N Van Ewijk, H Neisingh, P Van Uden, GA Rongen, P Koopmans and RJ Bertz

Clin Pharmacol Ther 84: 698-703; advance online publication, June 4, 2008; doi:10.1038/clpt.2008.106

Influence of Solute Carriers on the Pharmacokinetics of CYP3A4 Probes

RM Franke, SD Baker, RH Mathijssen, EG Schuetz and A Sparreboom

Clin Pharmacol Ther 84: 704-709; advance online publication, May 28, 2008; doi:10.1038/clpt.2008.94

Effects of Breast Pumping on the Pharmacokinetics and Pharmacodynamics of Ethanol During Lactation

MY Pepino and JA Mennella

Clin Pharmacol Ther 84: 710-714; advance online publication, July 2, 2008; doi:10.1038/clpt.2008.119

beta-Adrenergic Receptor Gene Polymorphisms and beta-Blocker Treatment Outcomes in Hypertension

MA Pacanowski, Y Gong, RM Cooper-DeHoff, NJ Schork, MD Shriver, TY Langaee, CJ Pepine and JA Johnson

Clin Pharmacol Ther 84: 715-721; advance online publication, July 9, 2008; doi:10.1038/clpt.2008.139

Pharmacogenetics of Warfarin: Development of a Dosing Algorithm for Brazilian Patients

JA Perini, CJ Struchiner, E Silva-Assunção, ISC Santana, F Rangel, EB Ojopi, E Dias-Neto and G Suarez-Kurtz

Clin Pharmacol Ther 84: 722-728; advance online publication, August 27, 2008; doi:10.1038/clpt.2008.166

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Discovery & Development

Development

Discrete Event Simulation Applied to Pediatric Phase I Oncology Designs

JS Barrett, JM Skolnik, B Jayaraman, D Patel and PC Adamson

Clin Pharmacol Ther 84: 729-733; advance online publication, October 15, 2008; doi:10.1038/clpt.2008.193

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Regulation & Use

Practice

Personalized Therapeutics: HIV Treatment in Adolescents

NY Rakhmanina, EV Capparelli and JN van den Anker

Clin Pharmacol Ther 84: 734-740; advance online publication, October 1, 2008; doi:10.1038/clpt.2008.187

Ethics

Contraceptive Availability to Adolescents: Do American Values Violate Our Most Vulnerable? FREE

MJ Elders

Clin Pharmacol Ther 84: 741-745; advance online publication, September 17, 2008; doi:10.1038/clpt.2008.178

Public Policy

Government Support for Abstinence-Only-Until-Marriage Education FREE

K Duffy, DA Lynch and J Santinelli

Clin Pharmacol Ther 84: 746-748; advance online publication, October 15, 2008; doi:10.1038/clpt.2008.188

Education

The Adolescent With Asthma: Fostering Adherence to Optimize Therapy

BL Jones and KJ Kelly

Clin Pharmacol Ther 84: 749-753; advance online publication, October 22, 2008; doi:10.1038/clpt.2008.189

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Corrigendum

Corrigendum

CORRIGENDUM: New Imaging Approaches for Understanding Lung Cancer Response to Treatment FREE

Clin Pharmacol Ther 84: 754; doi:10.1038/clpt.2008.199

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