Biotherapeutics
TABLE OF CONTENTS
Volume 84, Issue 5 (November 2008)
Editorial |
News & Views |
Perspectives |
State of the Art |
Research |
Discovery & Development |
Regulation & Use |
Erratum
In This Issue
In This Issue
In This Issue
Clin Pharmacol Ther 84: 531; doi:10.1038/clpt.2008.196
See also: State of the Art by Wang et al. See also: Article by Kanebratt et al. See also: Article by Malik et al. See also: Article by Sepp-Lorenzino & RuddySee also: Article by Kingham & LietzanEditorial
Editorial
Clinical Pharmacology in the Era of Biotherapeutics
RL Lalonde and P Honig
Clin Pharmacol Ther 84: 533-536; doi:10.1038/clpt.2008.182
News & Views
Highlights
Highlights
Clin Pharmacol Ther 84: 538-539; doi:10.1038/clpt.2008.197
ASCPT News
ASCPT News
Clin Pharmacol Ther 84: 540-541; doi:10.1038/clpt.2008.198
Perspectives
Commentary
Bioinformatic Networks: Molecular Reticles for Pinpointing Pharmacological Target Selection
RS Faustino and A Terzic
Clin Pharmacol Ther 84: 543-545; doi:10.1038/clpt.2008.181
See also: Article by Hwang et al.Letters to the Editor
Pharmacodynamics of Propofol in Critically Ill Patients
D Takizawa, E Takizawa, H Hiraoka and S Saito
Clin Pharmacol Ther 84: 546; advance online publication, July 23, 2008; doi:10.1038/clpt.2008.145
Response to "Pharmacodynamics of Propofol in Critically Ill Patients"
CAJ Knibbe and MYM Peeters
Clin Pharmacol Ther 84: 547; advance online publication, September 17, 2008; doi:10.1038/clpt.2008.183
State of the Art
State of the Art
Monoclonal Antibody Pharmacokinetics and Pharmacodynamics
W Wang, EQ Wang and JP Balthasar
Clin Pharmacol Ther 84: 548-558; advance online publication, September 10, 2008; doi:10.1038/clpt.2008.170
Research
Report
Genetic Variants of the Organic Cation Transporter 2 Influence the Disposition of Metformin
IS Song, HJ Shin, EJ Shim, IS Jung, WY Kim, JH Shon and JG Shin
Clin Pharmacol Ther 84: 559-562; advance online publication, April 9, 2008; doi:10.1038/clpt.2008.61
Articles
Identification of Information Flow-Modulating Drug Targets: A Novel Bridging Paradigm for Drug Discovery
W-C Hwang, A Zhang and M Ramanathan
Clin Pharmacol Ther 84: 563-572; advance online publication, July 9, 2008; doi:10.1038/clpt.2008.129
Abstract | Full Text | PDF | Supplementary information
See also: Commentary by Faustino & TerzicRole of Pegylated Interferon-
-2a and Ribavirin Concentrations in Sustained Viral Response in HCV/HIV-Coinfected Patients
LF Lopez-Cortes, B Valera-Bestard, A Gutierrez-Valencia, R Ruiz-Valderas, L Jimenez, A Arizcorreta, A Terrón and P Viciana
Clin Pharmacol Ther 84: 573-580; advance online publication, July 2, 2008; doi:10.1038/clpt.2008.110
Warfarin With Fluoroquinolones, Sulfonamides, or Azole Antifungals: Interactions and the Risk of Hospitalization for Gastrointestinal Bleeding
H Schelleman, WB Bilker, CM Brensinger, X Han, SE Kimmel and S Hennessy
Clin Pharmacol Ther 84: 581-588; advance online publication, August 6, 2008; doi:10.1038/clpt.2008.150
Cytochrome P450 Induction by Rifampicin in Healthy Subjects: Determination Using the Karolinska Cocktail and the Endogenous CYP3A4 Marker 4
-Hydroxycholesterol
KP Kanebratt, U Diczfalusy, T Bäckström, E Sparve, E Bredberg, Y Böttiger, TB Andersson and L Bertilsson
Clin Pharmacol Ther 84: 589-594; advance online publication, July 23, 2008; doi:10.1038/clpt.2008.132
Thorough QT/QTc Study in Patients With Advanced Parkinson's Disease: Cardiac Safety of Rotigotine
M Malik, J-O Andreas, K Hnatkova, J Hoeckendorff, W Cawello, M Middle, R Horstmann and M Braun
Clin Pharmacol Ther 84: 595-603; advance online publication, July 23, 2008; doi:10.1038/clpt.2008.143
Correlations of Maternal Buprenorphine Dose, Buprenorphine, and Metabolite Concentrations in Meconium With Neonatal Outcomes
SL Kacinko, HE Jones, RE Johnson, RE Choo and MA Huestis
Clin Pharmacol Ther 84: 604-612; advance online publication, August 13, 2008; doi:10.1038/clpt.2008.156
Availability and Choice of Antimalarials at Medicine Outlets in Ghana: The Question of Access to Effective Medicines for Malaria Control
KO Buabeng, M Duwiejua, LK Matowe, F Smith and H Enlund
Clin Pharmacol Ther 84: 613-619; advance online publication, July 9, 2008; doi:10.1038/clpt.2008.130
Discovery & Development
Translational Medicine
Stem Cells: Biologics for Regeneration
TJ Nelson, A Behfar and A Terzic
Clin Pharmacol Ther 84: 620-623; advance online publication, August 13, 2008; doi:10.1038/clpt.2008.146
Development
Safety Issues Specific to Clinical Development of Protein Therapeutics
CA Haller, ME Cosenza and JT Sullivan
Clin Pharmacol Ther 84: 624-627; advance online publication, August 13, 2008; doi:10.1038/clpt.2008.158
Challenges and Opportunities for Local and Systemic Delivery of siRNA and Antisense Oligonucleotides
L Sepp-Lorenzino and MK Ruddy
Clin Pharmacol Ther 84: 628-632; advance online publication, September 17, 2008; doi:10.1038/clpt.2008.174
Regulation & Use
Public Policy
Current Regulatory and Legal Considerations for Follow-On Biologics
RF Kingham and E Lietzan
Clin Pharmacol Ther 84: 633-635; advance online publication, August 20, 2008; doi:10.1038/clpt.2008.159
