Imaging

TABLE OF CONTENTS

Volume 84, Issue 4 (October 2008)

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In This Issue

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Editorial

Editorial

Imaging as a Biomarker for Therapy Response: Cancer as a Prototype for the Creation of Research Resources

G McLennan, L Clarke and RJ Hohl

Clin Pharmacol Ther 84: 433-436; doi:10.1038/clpt.2008.171

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News & Views

Highlights

Highlights

Clin Pharmacol Ther 84: 438-439; doi:10.1038/clpt.2008.175

ASCPT News

ASCPT News

Clin Pharmacol Ther 84: 440-441; doi:10.1038/clpt.2008.176

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Perspectives

Commentaries

Imaging Guiding Therapy Development in Lymphoma

BK Link

Clin Pharmacol Ther 84: 443-445; doi:10.1038/clpt.2008.167

The PharmD Investigator in Clinical Pharmacology: Supply and Demand

JL Cohen

Clin Pharmacol Ther 84: 445-447; doi:10.1038/sj.clpt.6100475

See also: Article by Figg
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State of the Art

State of the Art

The Reference Image Database to Evaluate Response to Therapy in Lung Cancer (RIDER) Project: A Resource for the Development of Change-Analysis Software FREE

SG Armato III, CR Meyer, MF McNitt-Gray, G McLennan, AP Reeves, BY Croft and LP Clarke; The RIDER Research Group

Clin Pharmacol Ther 84: 448-456; advance online publication, August 27, 2008; doi:10.1038/clpt.2008.161

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Research

Reports

ABCB1 Haplotypes Differentially Affect the Pharmacokinetics of the Acid and Lactone Forms of Simvastatin and Atorvastatin FREE

JE Keskitalo, KJ Kurkinen, PJ Neuvonen and M Niemi

Clin Pharmacol Ther 84: 457-461; advance online publication, March 26, 2008; doi:10.1038/clpt.2008.25

Plasma Concentrations of Oral Oxycodone Are Greatly Increased in the Elderly

A Liukas, K Kuusniemi, R Aantaa, P Virolainen, M Neuvonen, PJ Neuvonen and KT Olkkola

Clin Pharmacol Ther 84: 462-467; advance online publication, April 16, 2008; doi:10.1038/clpt.2008.64

Articles

Pharmacokinetics and Pharmacodynamic Effects of Oral GLP-1 and PYY3-36: A Proof-of-concept Study in Healthy Subjects

C Beglinger, B Poller, E Arbit, C Ganzoni, S Gass, I Gomez-Orellana and J Drewe

Clin Pharmacol Ther 84: 468-474; advance online publication, March 26, 2008; doi:10.1038/clpt.2008.35

The Effect of Moxifloxacin on QTc and Implications for the Design of Thorough QT Studies FREE

DM Bloomfield, JT Kost, K Ghosh, D Hreniuk, LA Hickey, MJ Guitierrez, K Gottesdiener and JA Wagner

Clin Pharmacol Ther 84: 475-480; advance online publication, March 26, 2008; doi:10.1038/clpt.2008.33

Pharmacodynamics and Pharmacokinetics of the Novel Thrombopoietin Mimetic Peptide RWJ-800088 in Humans

M Liem-Moolenaar, D Cerneus, CJ Molloy, D End, KH Brown, ML de Kam, AF Cohen, Y van Hensbergen and J Burggraaf

Clin Pharmacol Ther 84: 481-487; advance online publication, May 21, 2008; doi:10.1038/clpt.2008.96

Effects of Gemfibrozil and Atorvastatin on the Pharmacokinetics of Repaglinide in Relation to SLCO1B1 Polymorphism

A Kalliokoski, JT Backman, KJ Kurkinen, PJ Neuvonen and M Niemi

Clin Pharmacol Ther 84: 488-496; advance online publication, April 16, 2008; doi:10.1038/clpt.2008.74

Mechanism of Ritonavir Changes in Methadone Pharmacokinetics and Pharmacodynamics: I. Evidence Against CYP3A Mediation of Methadone Clearance FREE

ED Kharasch, PS Bedynek, S Park, D Whittington, A Walker and C Hoffer

Clin Pharmacol Ther 84: 497-505; advance online publication, July 9, 2008; doi:10.1038/clpt.2008.104

See also: Article by Kharasch et al.
Mechanism of Ritonavir Changes in Methadone Pharmacokinetics and Pharmacodynamics: II. Ritonavir Effects on CYP3A and P-Glycoprotein Activities FREE

ED Kharasch, PS Bedynek, A Walker, D Whittington and C Hoffer

Clin Pharmacol Ther 84: 506-512; advance online publication, July 9, 2008; doi:10.1038/clpt.2008.102

See also: Article by Kharasch et al.
A Context-Learning Pharmacotherapy Program for Preclinical Medical Students Leads to More Rational Drug Prescribing During Their Clinical Clerkship in Internal Medicine

MC Richir, J Tichelaar, F Stam, A Thijs, SA Danner, AJ Schneider and ThPGM de Vries

Clin Pharmacol Ther 84: 513-516; advance online publication, April 23, 2008; doi:10.1038/clpt.2008.82

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Discovery & Development

Discovery

New Imaging Approaches for Understanding Lung Cancer Response to Treatment FREE

J de Ryk, E Namati, J Thiesse and G McLennan

Clin Pharmacol Ther 84: 517-522; advance online publication, September 3, 2008; doi:10.1038/clpt.2008.160

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Regulation & Use

Public Policy

Imaging as a Tumor Biomarker in Oncology Drug Trials for Lung Cancer: The FDA Perspective

N Petrick, DG Brown, O Suleiman and KJ Myers

Clin Pharmacol Ther 84: 523-525; advance online publication, August 20, 2008; doi:10.1038/clpt.2008.155

Education

The Pharm.D. Investigator in Clinical Pharmacology: Supply and Demand

WD Figg

Clin Pharmacol Ther 84: 526-529; advance online publication, October 31, 2007; doi:10.1038/sj.clpt.6100423

See also: Commentary by Cohen

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