Highlights

Highlights

Clin Pharmacol Ther 84: 296-297; doi:10.1038/clpt.2008.163

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Point/Counterpoint

The Critical Path of Warfarin Dosing: Finding an Optimal Dosing Strategy Using Pharmacogenetics

LJ Lesko

Clin Pharmacol Ther 84: 301-303; doi:10.1038/clpt.2008.133

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Warfarin and Pharmacogenomic Testing: The Case for Restraint

DA Garcia

Clin Pharmacol Ther 84: 303-305; doi:10.1038/clpt.2008.131

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Commentaries

Individual Genomes Instead of Race for Personalized Medicine

PC Ng, Q Zhao, S Levy, RL Strausberg and JC Venter

Clin Pharmacol Ther 84: 306-309; doi:10.1038/clpt.2008.114

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What's Needed for Personalized Therapy in Smoking Cessation

RS Epstein

Clin Pharmacol Ther 84: 309-310; doi:10.1038/clpt.2008.125

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How European Regulators View Foreign Data in the Approval Process

A Breckenridge and I Hudson

Clin Pharmacol Ther 84: 311-312; doi:10.1038/clpt.2008.84

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Letters to the Editor

The Need for Clinical Pharmacology Is Greater Than Ever

DJ Goldstein, PK Honig and S Spielberg

Clin Pharmacol Ther 84: 313; advance online publication, April 16, 2008; doi:10.1038/clpt.2008.71

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Reports

Racial Differences in Blood Pressure Response to Angiotensin-Converting Enzyme Inhibitors in Children: A Meta-Analysis

JS Li, CM Baker-Smith, PB Smith, V Hasselblad, MD Murphy, RM Califf and DK Benjamin Jr.

Clin Pharmacol Ther 84: 315-319; advance online publication, June 11, 2008; doi:10.1038/clpt.2008.113

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Toward Personalized Therapy for Smoking Cessation: A Randomized Placebo-controlled Trial of Bupropion

F Patterson, RA Schnoll, EP Wileyto, A Pinto, LH Epstein, PG Shields, LW Hawk, RF Tyndale, N Benowitz and C Lerman

Clin Pharmacol Ther 84: 320-325; advance online publication, April 2, 2008; doi:10.1038/clpt.2008.57

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Articles

Use of Pharmacogenetic and Clinical Factors to Predict the Therapeutic Dose of Warfarin

BF Gage, C Eby, JA Johnson, E Deych, MJ Rieder, PM Ridker, PE Milligan, G Grice, P Lenzini, AE Rettie, CL Aquilante, L Grosso, S Marsh, T Langaee, LE Farnett, D Voora, DL Veenstra, RJ Glynn, A Barrett and HL McLeod

Clin Pharmacol Ther 84: 326-331; advance online publication, February 27, 2008; doi:10.1038/clpt.2008.10

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Dosing Algorithms to Predict Warfarin Maintenance Dose in Caucasians and African Americans

H Schelleman, J Chen, Z Chen, J Christie, CW Newcomb, CM Brensinger, M Price, AS Whitehead, C Kealey, CF Thorn, FF Samaha and SE Kimmel

Clin Pharmacol Ther 84: 332-339; advance online publication, July 2, 2008; doi:10.1038/clpt.2008.101

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Characteriation of Clinical Data Packages Using Foreign Data in New Drug Applications in Japan

M Tanaka and T Nagata

Clin Pharmacol Ther 84: 340-346; advance online publication, September 5, 2007; doi:10.1038/sj.clpt.6100346

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Pharmacokinetics/Genotype Associations for Major Cytochrome P450 Enzymes in Native and First- and Third-generation Japanese Populations: Comparison With Korean, Chinese, and Caucasian Populations

SP Myrand, K Sekiguchi, MZ Man, X Lin, R-Y Tzeng, C-H Teng, B Hee, M Garrett, H Kikkawa, C-Y Lin, SM Eddy, J Dostalik, J Mount, J Azuma, Y Fujio, I-J Jang, S-G Shin, MR Bleavins, JA Williams, JD Paulauskis and KD Wilner

Clin Pharmacol Ther 84: 347-361; advance online publication, March 19, 2008; doi:10.1038/sj.clpt.6100482

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Development of a Large-Scale De-Identified DNA Biobank to Enable Personalized Medicine

DM Roden, JM Pulley, MA Basford, GR Bernard, EW Clayton, JR Balser and DR Masys

Clin Pharmacol Ther 84: 362-369; advance online publication, May 21, 2008; doi:10.1038/clpt.2008.89

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Changes in Enoxaparin Pharmacokinetics During Pregnancy and Implications for Antithrombotic Therapeutic Strategy

C Lebaudy, JS Hulot, Z Amoura, N Costedoat-Chalumeau, R Serreau, A Ankri, J Conard, A Cornet, M Dommergues, JC Piette and P Lechat

Clin Pharmacol Ther 84: 370-377; advance online publication, April 23, 2008; doi:10.1038/clpt.2008.73

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Model-Based Approach and Signal Detection Theory to Evaluate the Performance of Recruitment Centers in Clinical Trials With Antidepressant Drugs

E Merlo-Pich and R Gomeni

Clin Pharmacol Ther 84: 378-384; advance online publication, April 30, 2008; doi:10.1038/clpt.2008.70

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Application of Software Design Principles and Debugging Methods to an Analgesia Prescription Reduces Risk of Severe Injury From Medical Use of Opioids

SM Belknap, H Moore, SA Lanzotti, PR Yarnold, M Getz, DL Deitrick, A Peterson, J Akeson, T Maurer, RC Soltysik, GA Storm and I Brooks

Clin Pharmacol Ther 84: 385-392; advance online publication, March 19, 2008; doi:10.1038/clpt.2008.24

Abstract | Full Text | PDF

Pharmacogenetic Pathway Analysis of Irinotecan

GL Rosner, JC Panetta, F Innocenti and MJ Ratain

Clin Pharmacol Ther 84: 393-402; advance online publication, April 16, 2008; doi:10.1038/clpt.2008.63

Abstract | Full Text | PDF | Supplementary information

Discovery

Genetic Variation in Drug Transporters in Ethnic Populations

CD Cropp, SW Yee and KM Giacomini

Clin Pharmacol Ther 84: 412-416; advance online publication, June 4, 2008; doi:10.1038/clpt.2008.98

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Ethics

Ethics at the Intersection of Pharmacoethnicity

KT FitzGerald

Clin Pharmacol Ther 84: 424-426; advance online publication, July 2, 2008; doi:10.1038/clpt.2008.126

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Erratum & Corrigenda

CORRIGENDUM: Use of Pharmacogenetic and Clinical Factors to Predict the Therapeutic Dose of Warfarin

Clin Pharmacol Ther 84: 430; doi:10.1038/clpt.2008.112

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ERRATUM: Propafenone for the Prevention of Atrial Tachyarrhythmias After Cardiac Surgery: A Randomized, Double-blind Placebo-controlled Trial

Clin Pharmacol Ther 84: 430; doi:10.1038/clpt.2008.149

Abstract | Full Text | PDF