FIGURE 2

The genotypes of James Watson and J. Craig Venter in six major CYP genes involved in drug metabolism. This is not a comprehensive list; there are additional genes with genetic variants relevant to ADRs¹⁶ that are not shown here. Dr. Watson's genotypes were obtained from the CSHL website (http://jimwatsonsequence.cshl.edu) and Dr. Venter's from Levy et al. ⁸ Dr. Watson's sequence comes from the relatively recent 454 Life Sciences technology and may need further validation to assess accuracy. The CYP variants' effects and allele designations are from the Human Cytochrome P450 Allele Nomenclature Committee (http://www.cypalleles.ki.se). The wild-type allele for a CYP gene is designated *1A. The substrates for the CYP genes were taken from PharmGKB¹⁷ and are not complete lists. (Photographs from Wikimedia Commons (Watson) and Heather Kowalski (Venter).)