Pharmacoeconomics

TABLE OF CONTENTS

Volume 84, Issue 2 (August 2008)

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In This Issue

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Editorial

Editorial

Pharmacoeconomics in the Era of Individualized Medicine

SA Waldman and A Terzic

Clin Pharmacol Ther 84: 179-182; doi:10.1038/clpt.2008.142

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News & Views

Highlights

Highlights

Clin Pharmacol Ther 84: 184-185; doi:10.1038/clpt.2008.136

ASCPT News

ASCPT News

Clin Pharmacol Ther 84: 186-187; doi:10.1038/clpt.2008.138

Macroscopy

Pharmacoeconomics Is Coming of Age

LT Pizzi and VP Singh

Clin Pharmacol Ther 84: 188-190; doi:10.1038/clpt.2008.120

See also: Commentary by Hay
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Perspectives

Commentaries

Harnessing Economic Drivers for Successful Clinical Implementation of Pharmacogenetic Testing

PA Deverka and HL McLeod

Clin Pharmacol Ther 84: 191-193; doi:10.1038/clpt.2008.121

Nonprofit Biomedical Companies

RM Conti, DO Meltzer and MJ Ratain

Clin Pharmacol Ther 84: 194-197; doi:10.1038/clpt.2008.123

Using Pharmacoeconomics to Value Pharmacotherapy

JW Hay

Clin Pharmacol Ther 84: 197-200; doi:10.1038/clpt2008124

See also: Macroscopy by Pizzi & Singh
The European ACuteTox Project: A Modern Integrative In Vitro Approach to Better Prediction of Acute Toxicity

C Clemedson

Clin Pharmacol Ther 84: 200-202; doi:10.1038/clpt.2008.135

Letters to the Editor

The Unanswered Question: What Is the Determinant of S-1 Pharmacokinetics?

W Ichikawa, K Fujita and Y Sasaki

Clin Pharmacol Ther 84: 203; advance online publication, March 26, 2008; doi:10.1038/clpt.2008.60

Response to "The Unanswered Question: What Is the Determinant of S-1 Pharmacokinetics?"

Y Kaida, N Inui, T Suda, H Watanabe and K Chida

Clin Pharmacol Ther 84: 204; advance online publication, April 30, 2008; doi:10.1038/clpt.2008.81

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Research

Communications

CYP3A5 Genotype Has No Impact on Plasma Trough Concentrations of Lopinavir and Ritonavir in HIV-infected Subjects

RCE Estrela, AB Santoro, PF Barroso, M Tuyama and G Suarez-Kurtz

Clin Pharmacol Ther 84: 205-207; advance online publication, February 20, 2008; doi:10.1038/clpt.2008.12

Reports

Effects of Selective vs. Nonselective Cyclooxygenase Inhibition on Dynamic Renal Potassium Excretion: A Randomized Trial

RA Preston, D Afshartous and AB Alonso

Clin Pharmacol Ther 84: 208-211; advance online publication, February 27, 2008; doi:10.1038/clpt.2008.16

Early and Accurate Prediction of Peg-IFNs/Ribavirin Therapy Outcome in the Individual Patient With Chronic Hepatitis C by Modeling the Dynamics of the Infected Cells

P Colombatto, P Ciccorossi, AM Maina, L Civitano, F Oliveri, B Coco, V Romagnoli, F Bonino and MR Brunetto

Clin Pharmacol Ther 84: 212-215; advance online publication, March 19, 2008; doi:10.1038/clpt.2008.21

Articles

Development of Procedures for Early Screening of Smoking Cessation Medications in Humans

KA Perkins, C Lerman, ML Stitzer, CA Fonte, JL Briski, JA Scott and KNR Chengappa

Clin Pharmacol Ther 84: 216-221; advance online publication, March 19, 2008; doi:10.1038/clpt.2008.30

Effect of APOE Genotype on Lipid Levels in Patients With Coronary Heart Disease During a 3-Week Inpatient Rehabilitation Program

CY Vossen, MM Hoffmann, H Hahmann, B Wüsten, D Rothenbacher and H Brenner

Clin Pharmacol Ther 84: 222-227; advance online publication, March 19, 2008; doi:10.1038/clpt.2008.31

Models for Plasma Glucose, HbA1c, and Hemoglobin Interrelationships in Patients with Type 2 Diabetes Following Tesaglitazar Treatment

B Hamrén, E Björk, M Sunzel and MO Karlsson

Clin Pharmacol Ther 84: 228-235; advance online publication, March 19, 2008; doi:10.1038/clpt.2008.2

The Effect of CYP2C19 Polymorphism on the Pharmacokinetics and Pharmacodynamics of Clopidogrel: A Possible Mechanism for Clopidogrel Resistance

KA Kim, PW Park, SJ Hong and J-Y Park

Clin Pharmacol Ther 84: 236-242; advance online publication, March 5, 2008; doi:10.1038/clpt.2008.20

Genetic Influences in the Variation in Renal Clearance of Nicotine and Cotinine

NL Benowitz, CN Lessov-Schlaggar and GE Swan

Clin Pharmacol Ther 84: 243-247; advance online publication, April 2, 2008; doi:10.1038/clpt.2008.54

Effects of Pregnancy on CYP3A and P-glycoprotein Activities as Measured by Disposition of Midazolam and Digoxin: A University of Washington Specialized Center of Research Study

MF Hebert, TR Easterling, B Kirby, DB Carr, ML Buchanan, T Rutherford, KE Thummel, DP Fishbein and JD Unadkat

Clin Pharmacol Ther 84: 248-253; advance online publication, February 20, 2008; doi:10.1038/clpt.2008.1

Renal Function as a Predictor of Irinotecan-induced Neutropenia

FA de Jong, JM van der Bol, RHJ Mathijssen, T van Gelder, EAC Wiemer, A Sparreboom and J Verweij

Clin Pharmacol Ther 84: 254-262; advance online publication, February 20, 2008; doi:10.1038/sj.clpt.6100513

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Discovery & Development

Discovery

The Economics of Drug Discovery and the Ultimate Valuation of Pharmacotherapies in the Marketplace

JA Sollano, JM Kirsch, MV Bala, MG Chambers and LH Harpole

Clin Pharmacol Ther 84: 263-266; advance online publication, June 11, 2008; doi:10.1038/clpt.2008.117

Development

Optical Molecular Imaging: From Single Cell to Patient

EH Moriyama, G Zheng and BC Wilson

Clin Pharmacol Ther 84: 267-271; advance online publication, April 2, 2008; doi:10.1038/clpt.2008.58

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Regulation & Use

Practice

Economic Evaluation of Pharmacogenetic Tests

AC Wu and AL Fuhlbrigge

Clin Pharmacol Ther 84: 272-274; advance online publication, June 25, 2008; doi:10.1038/clpt.2008.127

Ethics

How Should Adverse Events Be Reported in US Clinical Trials?: Ethical Considerations

AE Shamoo and LI Katzel

Clin Pharmacol Ther 84: 275-278; advance online publication, February 27, 2008; doi:10.1038/clpt.2008.14

Public Policy

Pharmacoeconomics Comes of Age?

T Walley and A Breckenridge

Clin Pharmacol Ther 84: 279-280; advance online publication, June 18, 2008; doi:10.1038/clpt.2008.122

Education

The Use of Patient-Reported Outcome Measures in the Evaluation of Medical Products for Regulatory Approval

LB Burke, DL Kennedy, PH Miskala, EJ Papadopoulos and AM Trentacosti

Clin Pharmacol Ther 84: 281-283; advance online publication, June 25, 2008; doi:10.1038/clpt.2008.128

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