Anesthesiology
TABLE OF CONTENTS
Volume 84, Issue 1 (July 2008)
Editorial |
News & Views |
Perspectives |
State of the Art |
Research |
Discovery & Development |
Regulation & Use |
Corrigendum
In This Issue
In This Issue
In This Issue
Clin Pharmacol Ther 84: 1; doi:10.1038/clpt.2008.116
See also: Commentaries by Gupta & Eger IISee also: State of the Art by Minto & SchniderSee also: Articles by Pickering et al. See also: Articles by Uppoor et al. See also: Discovery by Eckenhoff et al. See also: Translational Medicine by AlkireEditorial
Editorial
Anesthesia: A Discipline That Incorporates Clinical Pharmacology Across the DDRU Continuum
MJ Avram, DK Gupta and AJ Atkinson Jr
Clin Pharmacol Ther 84: 3-6; doi:10.1038/clpt.2008.99
News & Views
Highlights
Highlights
Clin Pharmacol Ther 84: 8-9; doi:10.1038/clpt.2008.115
Ascpt News
Ascpt News
Clin Pharmacol Ther 84: 10-11; doi:10.1038/clpt.2008.118
Books
Molecular Therapeutics: 21st Century Medicine
Reviewed by A Gaedigk and KA Neville
Clin Pharmacol Ther 84: 12-13; doi:10.1038/clpt.2008.105
Perspectives
Commentaries
Inhaled Anesthesia: The Original Closed-Loop Drug Administration Paradigm
DK Gupta and EI Eger II
Clin Pharmacol Ther 84: 15-18; doi:10.1038/clpt.2008.85
Early Drug Distribution: A Generally Neglected Aspect of Pharmacokinetics of Particular Relevance to Intravenously Administered Anesthetic Agents
TK Henthorn, TC Krejcie and MJ Avram
Clin Pharmacol Ther 84: 18-22; doi:10.1038/clpt.2008.107
Letters to the Editor
Herbal Remedies in Resource-poor Settings: Friend or Foe?
KE Dooley, C Flexner and AS Andrade
Clin Pharmacol Ther 84: 23; advance online publication, February 6, 2008; doi:10.1038/sj.clpt.6100512
Early Access to New Medicines
A Breckenridge and T Walley
Clin Pharmacol Ther 84: 23-25; advance online publication, February 20, 2008; doi:10.1038/clpt.2008.19
Beyond Genomics: Epigenetics and Epigenomics
J Peedicayil
Clin Pharmacol Ther 84: 25-26; advance online publication, February 27, 2008; doi:10.1038/clpt.2008.26
State of the Art
State of the Art
Contributions of PK/PD Modeling to Intravenous Anesthesia
CF Minto and TW Schnider
Clin Pharmacol Ther 84: 27-38; advance online publication, May 7, 2008; doi:10.1038/clpt.2008.100
Research
Reports
COX Inhibitors Downregulate PDE4D Expression in a Clinical Model of Inflammatory Pain
X-M Wang, M Hamza, SM Gordon, SM Wahl and RA Dionne
Clin Pharmacol Ther 84: 39-42; advance online publication, February 20, 2008; doi:10.1038/sj.clpt.6100501
Influence of CYP3A4, CYP3A5, and ABCB1 Genotype and Expression on Budesonide Pharmacokinetics: A Possible Role of Intestinal CYP3A4 Expression
M Ufer, K Dilger, L Leschhorn, LM Daufresne, I Mosyagin, P Rosenstiel, R Haesler, T Kuehbacher, S Nikolaus, S Schreiber and I Cascorbi
Clin Pharmacol Ther 84: 43-46; advance online publication, March 5, 2008; doi:10.1038/sj.clpt.6100505
Articles
Acetaminophen Reinforces Descending Inhibitory Pain Pathways
G Pickering, V Estève, M-A Loriot, A Eschalier and C Dubray
Clin Pharmacol Ther 84: 47-51; advance online publication, October 24, 2007; doi:10.1038/sj.clpt.6100403
Pharmacodynamics of Carbamazepine-mediated Induction of CYP3A4, CYP1A2, and Pgp as Assessed by Probe Substrates Midazolam, Caffeine, and Digoxin
MO Magnusson, M-L Dahl, J Cederberg, MO Karlsson and R Sandström
Clin Pharmacol Ther 84: 52-62; advance online publication, October 31, 2007; doi:10.1038/sj.clpt.6100431
Drugs with Anticholinergic Properties as a Risk Factor for Psychosis in Patients Affected by Alzheimer's Disease
I Cancelli, L Valentinis, G Merlino, M Valente and GL Gigli
Clin Pharmacol Ther 84: 63-68; advance online publication, November 7, 2007; doi:10.1038/sj.clpt.6100435
The Use of Imaging in the Early Development of Neuropharmacological Drugs: A Survey of Approved NDAs
RS Uppoor, P Mummaneni, E Cooper, HH Pien, AG Sorensen, J Collins, MU Mehta and SU Yasuda
Clin Pharmacol Ther 84: 69-74; advance online publication, November 21, 2007; doi:10.1038/sj.clpt.6100422
Effect of an Antiretroviral Regimen Containing Ritonavir Boosted Lopinavir on Intestinal and Hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected Patients
C Wyen, U Fuhr, D Frank, RE Aarnoutse, T Klaassen, A Lazar, A Seeringer, O Doroshyenko, JC Kirchheiner, F Abdulrazik, N Schmeisser, C Lehmann, W Hein, E Schömig, DM Burger, G Fätkenheuer and A Jetter
Clin Pharmacol Ther 84: 75-82; advance online publication, January 9, 2008; doi:10.1038/sj.clpt.6100452
Prospective Study of Warfarin Dosage Requirements Based on CYP2C9 and VKORC1 Genotypes
M-S Wen, MTM Lee, J-J Chen, H-P Chuang, L-S Lu, C-H Chen, T-H Lee, C-T Kuo, F-M Sun, Y-J Chang, P-L Kuan, Y-F Chen, M-J Charng, C-Y Ray, J-Y Wu and Y-T Chen
Clin Pharmacol Ther 84: 83-89; advance online publication, January 9, 2008; doi:10.1038/sj.clpt.6100453
Declining Public Health Burden of Digoxin Toxicity From 1991 to 2004
K Haynes, DF Heitjan, PA Kanetsky and S Hennessy
Clin Pharmacol Ther 84: 90-94; advance online publication, December 19, 2007; doi:10.1038/sj.clpt.6100458
Pharmacogenetic Characterization of Sulfasalazine Disposition Based on NAT2 and ABCG2 (BCRP) Gene Polymorphisms in Humans
Y Yamasaki, I Ieiri, H Kusuhara, T Sasaki, M Kimura, H Tabuchi, Y Ando, S Irie, JA Ware, Y Nakai, S Higuchi and Y Sugiyama
Clin Pharmacol Ther 84: 95-103; advance online publication, January 2, 2008; doi:10.1038/sj.clpt.6100459
Propafenone for the Prevention of Atrial Tachyarrhythmias After Cardiac Surgery: A Randomized, Double-blind Placebo-controlled Trial
K Mörike, KT Kivistö, E Schaeffeler, C Jägle, S Igel, S Drescher, R Fux, C Marx, U Hofmann, C Engel, F Wagner, U Delabar, C Meisner, D Bail, JO Böhm, CH Gleiter, G Ziemer, JG Rein, KD Hellberg, M Eichelbaum and M Schwab
Clin Pharmacol Ther 84: 104-110; advance online publication, January 2, 2008; doi:10.1038/sj.clpt.6100473
Population Pharmacokinetic Model for Docetaxel in Patients with Varying Degrees of Liver Function: Incorporating Cytochrome P450 3A Activity Measurements
AC Hooker, AJ Ten Tije, MA Carducci, J Weber, E Garrett-Mayer, H Gelderblom, WP Mcguire, J Verweij, MO Karlsson and SD Baker
Clin Pharmacol Ther 84: 111-118; advance online publication, January 9, 2008; doi:10.1038/sj.clpt.6100476
The Use of Angiotensin-converting Enzyme Inhibitors and Diuretics Is Associated With a Reduced Incidence of Impairment on Cognition in Elderly Women
S Yasar, J Zhou, R Varadhan and MC Carlson
Clin Pharmacol Ther 84: 119-126; advance online publication, March 19, 2008; doi:10.1038/sj.clpt.6100483
Exposure-response Analysis for Spontaneously Reported Dizziness in Pregabalin-treated Patient With Generalized Anxiety Disorder
K Ito, MM Hutmacher, J Liu, R Qiu, B Frame and R Miller
Clin Pharmacol Ther 84: 127-135; advance online publication, February 6, 2008; doi:10.1038/sj.clpt.6100491
Pharmacokinetic/Pharmacodynamic Modeling of Renin Biomarkers in Subjects Treated With the Renin Inhibitor Aliskiren
Y Hong, J Dingemanse and DE Mager
Clin Pharmacol Ther 84: 136-143; advance online publication, February 20, 2008; doi:10.1038/sj.clpt.6100495
Discovery & Development
Discovery
From Anesthetic Mechanisms Research to Drug Discovery
RG Eckenhoff, W Zheng and MB Kelz
Clin Pharmacol Ther 84: 144-148; advance online publication, April 30, 2008; doi:10.1038/clpt.2008.77
Translational Medicine
Probing the Mind: Anesthesia and Neuroimaging
MT Alkire
Clin Pharmacol Ther 84: 149-152; advance online publication, April 16, 2008; doi:10.1038/clpt.2008.75
Development
Pharmacokinetics and Pharmacodynamics of Intravenously Administered Anesthetic Drugs: Concepts and Lessons for Drug Development
SE Kern and DR Stanski
Clin Pharmacol Ther 84: 153-157; advance online publication, May 7, 2008; doi:10.1038/clpt.2008.80
Regulation & Use
Practice
Adverse Drug Reactions With Halogenated Anesthetics
ED Kharasch
Clin Pharmacol Ther 84: 158-162; advance online publication, May 28, 2008; doi:10.1038/clpt.2008.97
Ethics
A Continuum for Using Placebo Interventions in Regional Anesthesia and Analgesia Studies
DB Waisel and RD Truog
Clin Pharmacol Ther 84: 163-165; advance online publication, May 7, 2008; doi:10.1038/clpt.2008.87
Public Policy
Regulatory Challenges Facing Closed-Loop Anesthetic Drug Infusion Devices
PJ Manberg, CM Vozella and SD Kelley
Clin Pharmacol Ther 84: 166-169; advance online publication, May 7, 2008; doi:10.1038/clpt.2008.79
Education
Simulated Drug Administration: An Emerging Tool for Teaching Clinical Pharmacology During Anesthesiology Training
MMRF Struys, T De Smet and EP Mortier
Clin Pharmacol Ther 84: 170-174; advance online publication, April 23, 2008; doi:10.1038/clpt.2008.76
