Translational Pharmacology
TABLE OF CONTENTS
Volume 83, Issue 6 (June 2008)
Editorial |
News & Views |
Perspectives |
State of the Art |
Research |
Discovery & Development |
Regulation & Use
In This Issue
In This Issue
In This Issue
Clin Pharmacol Ther 83: 795; doi:10.1038/clpt.2008.93
See also: State of the Art by Muruganandan & SinalSee also: Articles by Lai et al. See also: Articles by Cao et al. See also: Discovery by HendersonSee also: Practice by Dolovich et al.Editorial
Editorial
Translational Pharmacology: Harnessing Increased Specialization of Research Within the Basic Biological Sciences
GJ Anger and M Piquette-Miller
Clin Pharmacol Ther 83: 797-801; doi:10.1038/clpt.2008.83
News & Views
Highlights
Highlights
Clin Pharmacol Ther 83: 802-803; doi:10.1038/clpt.2008.90
ASCPT News
ASCPT News
Clin Pharmacol Ther 83: 804-805; doi:10.1038/clpt.2008.91
Books
Pharmacovigilance, 2nd Edition FREE
Reviewed by WP Stephenson
Clin Pharmacol Ther 83: 806-807; doi:10.1038/clpt.2008.78
Perspectives
Commentary
Effects of Inflammation on Pharmacokinetics/Pharmacodynamics: Increasing Recognition of Its Contribution to Variability in Response
VD Schmith and JF Foss
Clin Pharmacol Ther 83: 809-811; doi:10.1038/clpt.2008.62
See also: Translational Medicine by Robertson et al. See also: Translational Medicine by Nolin et al.Letters to the Editor
Blunting of the Cardiovascular Effect of Aspirin by Ibuprofen: What Is the Evidence?
R van Westrhenen, CC Gispen-de Wied and JFF Lekkerkerker
Clin Pharmacol Ther 83: 812; doi:10.1038/sj.clpt.6100338
Response to "Pharmacodynamic Interaction Between Aspirin and Ibuprofen: A Plausible Mechanism of Aspirin Resistance"
P Patrignani, G Renda, S Tacconelli, ML Capone, D Sacchetta, F Santarelli, MG Sciulli, M Zimarino, M Grana, E D'Amelio, M Zurro, C Patrono and R De Caterina
Clin Pharmacol Ther 83: 812-813; doi:10.1038/sj.clpt.6100368
Clinical Development of TLR Agonists as Adjuvants: "Post-alum Adjuvant" Candidates May Reach Beyond Their Intended Purpose
SJ Green
Clin Pharmacol Ther 83: 813-814; advance online publication, January 23, 2008; doi:10.1038/sj.clpt.6100494
Response to "'Post-alum Adjuvants' May Reach Beyond Their Intended Purpose: The Clinical Development of TLR Agonists"
VEJC Schijns and WGJ Degen
Clin Pharmacol Ther 83: 814; advance online publication, March 26, 2008; doi:10.1038/clpt.2008.56
The Polymorphisms Asn130Asp and Val174Ala in OATP1B1 and the CYP2C9 Allele *3 Independently Affect Torsemide Pharmacokinetics and Pharmacodynamics
SV Vormfelde, MR Toliat, M Schirmer, I Meineke, P Nürnberg and J Brockmöller
Clin Pharmacol Ther 83: 815-817; advance online publication, November 14, 2007; doi:10.1038/sj.clpt.6100404
State of the Art
State of the Art
Mice as Clinically Relevant Models for the Study of Cytochrome P450-dependent Metabolism
S Muruganandan and CJ Sinal
Clin Pharmacol Ther 83: 818-828; advance online publication, March 19, 2008; doi:10.1038/clpt.2008.50
Research
Articles
PK/PD Model of Indisulam and Capecitabine: Interaction Causes Excessive Myelosuppression
AS Zandvliet, WS Siegel-Lakhai, JH Beijnen, W Copalu, M-C Etienne-Grimaldi, G Milano, JHM Schellens and ADR Huitema
Clin Pharmacol Ther 83: 829-839; advance online publication, September 12, 2007; doi:10.1038/sj.clpt.6100344
Pharmacokinetics, Pharmacodynamics, and Safety of a Prostaglandin D2 Receptor Antagonist
E Lai, LA Wenning, TM Crumley, I De Lepeleire, F Liu, JN de Hoon, A Van Hecken, M Depré, D Hilliard, H Greenberg, G O'Neill, K Metters, KG Gottesdiener and JA Wagner
Clin Pharmacol Ther 83: 840-847; advance online publication, September 19, 2007; doi:10.1038/sj.clpt.6100345
Effect of Semen Sampling Frequency on Seminal Antiretroviral Drug Concentration
YJ Cao, TT Ndovi, TL Parsons, AM Guidos, B Caffo and CW Hendrix
Clin Pharmacol Ther 83: 848-856; advance online publication, October 3, 2007; doi:10.1038/sj.clpt.6100356
Modeling and Simulation to Support Dose Selection and Clinical Development of SC-75416, a Selective COX-2 Inhibitor for the Treatment of Acute and Chronic Pain
KG Kowalski, S Olson, AE Remmers and MM Hutmacher
Clin Pharmacol Ther 83: 857-866; advance online publication, September 19, 2007; doi:10.1038/sj.clpt.6100374
Pharmacokinetics and Safety of Saquinavir/Ritonavir and Omeprazole in HIV-infected Subjects
K Singh, L Dickinson, A Chaikan, D Back, C Fletcher, A Pozniak, G Moyle, M Nelson, B Gazzard, D Herath and M Boffito
Clin Pharmacol Ther 83: 867-872; advance online publication, September 26, 2007; doi:10.1038/sj.clpt.6100375
New Adaptive Method for Phase I Trials in Oncology
C Meille, JC Gentet, D Barbolosi, N André, F Doz and A Iliadis
Clin Pharmacol Ther 83: 873-881; advance online publication, October 24, 2007; doi:10.1038/sj.clpt.6100383
Individualized Compared With Conventional Dosing of Enoxaparin
MA Barras, SB Duffull, JJ Atherton and B Green
Clin Pharmacol Ther 83: 882-888; advance online publication, October 10, 2007; doi:10.1038/sj.clpt.6100399
Discovery & Development
Discovery
Lazarus's Gate: Challenges and Potential of Epigenetic Reprogramming of Somatic Cells
JT Henderson
Clin Pharmacol Ther 83: 889-893; advance online publication, March 26, 2008; doi:10.1038/clpt.2008.51
Translational Medicine
Inflammation and Altered Drug Clearance in Cancer: Transcriptional Repression of a Human CYP3A4 Transgene in Tumor-bearing Mice
GR Robertson, C Liddle and SJ Clarke
Clin Pharmacol Ther 83: 894-897; advance online publication, March 26, 2008; doi:10.1038/clpt.2008.55
See also: Commentary by Schmith & FossEmerging Evidence of the Impact of Kidney Disease on Drug Metabolism and Transport
TD Nolin, J Naud, FA Leblond and V Pichette
Clin Pharmacol Ther 83: 898-903; advance online publication, April 2, 2008; doi:10.1038/clpt.2008.59
See also: Commentary by Schmith & FossDevelopment
Mathematics for Understanding Disease
RR Bies, MR Gastonguay and SL Schwartz
Clin Pharmacol Ther 83: 904-908; advance online publication, March 26, 2008; doi:10.1038/clpt.2008.53
Development of Translational Pharmacokinetic–Pharmacodynamic Models
DE Mager and WJ Jusko
Clin Pharmacol Ther 83: 909-912; advance online publication, March 26, 2008; doi:10.1038/clpt.2008.52
Regulation & Use
Practice
Integrating Family Medicine and Pharmacy to Advance Primary Care Therapeutics
L Dolovich, K Pottie, J Kaczorowski, B Farrell, Z Austin, C Rodriguez, K Gaebel and C Sellors
Clin Pharmacol Ther 83: 913-917; advance online publication, March 19, 2008; doi:10.1038/clpt.2008.29
Public Policy
Animal Studies in the Development of Medical Countermeasures
R Roberts and SK McCune
Clin Pharmacol Ther 83: 918-920; advance online publication, March 5, 2008; doi:10.1038/clpt.2008.23
