Therapeutic Targeting
TABLE OF CONTENTS
Volume 83, Issue 5 (May 2008)
Editorial |
News & Views |
Perspectives |
State of the Art |
Research |
Discovery & Development |
Regulation & Use
In This Issue
In this Issue
Clin Pharmacol Ther 83: 649; doi:10.1038/clpt.2008.68
See also: State of the Art by Mimeault et al. See also: Articles by Lee et al. See also: Discovery by Gramolini et al. See also: Translational Medicine by Zhang et al. See also: Practice by Swen et al.Editorial
Therapeutic Targeting: A Crucible for Individualized Medicine
SA Waldman and A Terzic
Clin Pharmacol Ther 83: 651-654; doi:10.1038/clpt.2008.65
News & Views
Highlights
Highlights
Clin Pharmacol Ther 83: 656-657; doi:10.1038/clpt.2008.67
ASCPT News
ASCPT News
Clin Pharmacol Ther 83: 658-659; doi:10.1038/clpt.2008.69
Books
Pharmacometrics: The Science of Quantitative Pharmacology FREE
BE Houk
Clin Pharmacol Ther 83: 660-661; doi:10.1038/clpt.2008.22
Perspectives
Commentary
Are Trials of Intravascular Infusions of Autologous Mesenchymal Stem Cells in Patients With Multiple System Atrophy Currently Justified, and Are They Effective?
N Quinn, RA Barker and GK Wenning
Clin Pharmacol Ther 83: 663-665; doi:10.1038/sj.clpt.6100454
See also: Articles by Lee et al.Letters to the Editor
Risk Sharing and Payment by Results
A Breckenridge and T Walley
Clin Pharmacol Ther 83: 666-667; doi:10.1038/clpt.2008.15
Processed EEG (Bispectral Index) Is Not Appropriate for Characterizing Opioid Sedation
DK Gupta
Clin Pharmacol Ther 83: 667-668; doi:10.1038/sj.clpt.6100265
No Influence of ABCB1 Haplotypes on Methadone Dosage Requirement
S Crettol, J-J Déglon, J Besson, M Croquette-Krokar, R Hämmig, I Gothuey, M Monnat and CB Eap
Clin Pharmacol Ther 83: 668-669; doi:10.1038/sj.clpt.6100305
Response to "No Influence of ABCB1 Haplotypes on Methadone Dosage Requirement"
JK Coller, DT Barratt and AA Somogyi
Clin Pharmacol Ther 83: 669-670; doi:10.1038/sj.clpt.6100371
Development of CYP2D6 and CYP3A4 in the First Year of Life
TN Johnson, GT Tucker and A Rostami-Hodjegan
Clin Pharmacol Ther 83: 670-671; doi:10.1038/sj.clpt.6100327
Methadone-Induced QTc Prolongation: Is It Due to Stereoselective Block of hERG or to Inappropriate QT Interval Correction?
G Andrássy and A Szabo
Clin Pharmacol Ther 83: 671; advance online publication, April 9, 2008; doi:10.1038/sj.clpt.6100329
Response to "Methadone-Induced QTc Prolongation: Is it Due to Stereoselective Block of hERG or to Inappropriate QT Interval Correction?"
S Crettol, J Schlaepfer, H Abriel and CB Eap
Clin Pharmacol Ther 83: 672; doi:10.1038/sj.clpt.6100426
State of the Art
State of the Art
Recent Advances on the Molecular Mechanisms Involved in the Drug Resistance of Cancer Cells and Novel Targeting Therapies
M Mimeault, R Hauke and SK Batra
Clin Pharmacol Ther 83: 673-691; advance online publication, September 5, 2007; doi:10.1038/sj.clpt.6100296
Research
Articles
Autonomic Cardiovascular Control During a Novel Pharmacologic Alternative to Ganglionic Blockade
BW Wilkins, C Hesse, N Charkoudian, WT Nicholson, HP Sviggum, TP Moyer, MJ Joyner and JH Eisenach
Clin Pharmacol Ther 83: 692-701; advance online publication, August 8, 2007; doi:10.1038/sj.clpt.6100326
Estrogen Receptor Genotypes, Menopausal Status, and the Lipid Effects of Tamoxifen
NI Ntukidem, AT Nguyen, V Stearns, M Rehman, A Schott, T Skaar, Y Jin, P Blanche, L Li, S Lemler, J Hayden, RM Krauss, Z Desta, DA Flockhart and DF Hayes for The Consortium on Breast Cancer Pharmacogenomics (COBRA)
Clin Pharmacol Ther 83: 702-710; advance online publication, August 22, 2007; doi:10.1038/sj.clpt.6100343
IMPDH1 Gene Polymorphisms and Association With Acute Rejection in Renal Transplant Patients
J Wang, JW Yang, A Zeevi, SA Webber, DM Girnita, R Selby, J Fu, T Shah, V Pravica, IV Hutchinson and GJ Burckart
Clin Pharmacol Ther 83: 711-717; advance online publication, September 12, 2007; doi:10.1038/sj.clpt.6100347
An Association Study of Riluzole Serum Concentration and Survival and Disease Progression in Patients With ALS
GJ Groeneveld, HJM van Kan, L Lie-A-Huen, H-J Guchelaar and LH van den Berg
Clin Pharmacol Ther 83: 718-722; advance online publication, September 26, 2007; doi:10.1038/sj.clpt.6100382
Autologous Mesenchymal Stem Cell Therapy Delays the Progression of Neurological Deficits in Patients With Multiple System Atrophy
PH Lee, JW Kim, OY Bang, YH Ahn, IS Joo and K Huh
Clin Pharmacol Ther 83: 723-730; advance online publication, September 26, 2007; doi:10.1038/sj.clpt.6100386
See also: Commentary by Quinn et al.Comparison of Effects of Pitavastatin and Atorvastatin on Plasma Coenzyme Q10 in Heterozygous Familial Hypercholesterolemia: Results From a Crossover Study
M-a Kawashiri, A Nohara, H Tada, M Mori, M Tsuchida, S Katsuda, A Inazu, J Kobayashi, J Koizumi, H Mabuchi and M Yamagishi
Clin Pharmacol Ther 83: 731-739; advance online publication, October 24, 2007; doi:10.1038/sj.clpt.6100396
Combination of Phenotype Assessments and CYP2C9-VKORC1 Polymorphisms in the Determination of Warfarin Dose Requirements in Heavily Medicated Patients
V Michaud, M-C Vanier, D Brouillette, D Roy, L Verret, N Noel, I Taillon, G O'Hara, D Gossard, M Champagne, K Goodman, Y Renaud, A Brown, M Phillips, AM Ajami and J Turgeon
Clin Pharmacol Ther 83: 740-748; advance online publication, November 14, 2007; doi:10.1038/sj.clpt.6100434
Population Pharmacokinetics of Melphalan and Glutathione S-transferase Polymorphisms in Relation to Side Effects
A Kühne, O Sezer, U Heider, I Meineke, S Muhlke, W Niere, T Overbeck, K Hohloch, L Trümper, J Brockmöller and R Kaiser
Clin Pharmacol Ther 83: 749-757; advance online publication, October 3, 2007; doi:10.1038/sj.clpt.6100336
Discovery & Development
Discovery
Mass Spectrometry–Based Proteomics: A Useful Tool for Biomarker Discovery?
AO Gramolini, SM Peterman and T Kislinger
Clin Pharmacol Ther 83: 758-760; advance online publication, March 19, 2008; doi:10.1038/clpt.2008.18
Translational Medicine
Nanoparticles in Medicine: Therapeutic Applications and Developments
L Zhang, FX Gu, JM Chan, AZ Wang, RS Langer and OC Farokhzad
Clin Pharmacol Ther 83: 761-769; advance online publication, October 24, 2007; doi:10.1038/sj.clpt.6100400
Development
Pharmacokinetics of Alvimopan and Its Metabolite in Healthy Volunteers and Patients in Postoperative Ileus Trials
JF Foss, DM Fisher and VD Schmith
Clin Pharmacol Ther 83: 770-776; advance online publication, July 25, 2007; doi:10.1038/sj.clpt.6100292
Regulation & Use
Practice
Cholesterol—When Is Lower Better?
JB Warren
Clin Pharmacol Ther 83: 777-780; advance online publication, May 30, 2007; doi:10.1038/sj.clpt.6100254
Pharmacogenetics: From Bench to Byte
JJ Swen, I Wilting, AL de Goede, L Grandia, H Mulder, DJ Touw, A de Boer, JMH Conemans, TCG Egberts, OH Klungel, R Koopmans, J van der Weide, B Wilffert, H-J Guchelaar and VHM Deneer
Clin Pharmacol Ther 83: 781-787; advance online publication, February 6, 2008; doi:10.1038/sj.clpt.6100507
Ethics
When Should Re-consent of Subjects Participating in a Clinical Trial Be Requested? A Case-Oriented Algorithm to Assist in the Decision-Making Process
R Dal-Ré, C Avendaño, A Gil-Aguado, D Gracia and AL Caplan
Clin Pharmacol Ther 83: 788-793; advance online publication, September 19, 2007; doi:10.1038/sj.clpt.6100357
