Addictions
TABLE OF CONTENTS
Volume 83, Issue 4 (April 2008)
Editorial |
News & Views |
Perspectives |
State of the Art |
Research |
Discovery & Development |
Regulation & Use
In This Issue
In this Issue
Clin Pharmacol Ther 83: 501; doi:10.1038/sj.clpt.6100541
See also: Macroscopy by LeshnerSee also: Articles by Campa et al. See also: Articles by Feng et al. See also: Translational Medicine by George & WeinbergerSee also: Development by Schoedel & SellersEditorial
Editorial
Drug Addiction: A Critical Problem Calling for Novel Solutions
R Tyndale
Clin Pharmacol Ther 83: 503-506; doi:10.1038/clpt.2008.11
News & Views
Highlights
Highlights
Clin Pharmacol Ther 83: 508-509; doi:10.1038/sj.clpt.6100545
ASCPT News
ASCPT News
Clin Pharmacol Ther 83: 510-511; doi:10.1038/sj.clpt.6100540
Books
Clinical Pharmacology of Therapeutic Proteins
JT Sullivan
Clin Pharmacol Ther 83: 512; doi:10.1038/clpt.6100496
Macroscopy
By Now, "Harm Reduction" Harms Both Science and the Public Health
AI Leshner
Clin Pharmacol Ther 83: 513-514; doi:10.1038/sj.clpt.6100478
Perspectives
Point/Counterpoint
Marijuana as Medicine: Does It Have a Future?
MA Ware
Clin Pharmacol Ther 83: 515-517; doi:10.1038/clpt.2008.6
Smoked Marijuana as Medicine: Not Much Future
H Kalant
Clin Pharmacol Ther 83: 517-519; doi:10.1038/sj.clpt.6100497
Commentaries
Substance Abuse in Pregnant Women: Making Improved Detection a Good Clinical Outcome
R Araojo, S McCune and K Feibus
Clin Pharmacol Ther 83: 520-522; doi:10.1038/clpt.2008.13
See also: Practice by Koren et al.Continuing to Struggle with the Term "Harm Reduction"
ST Higgins
Clin Pharmacol Ther 83: 522-523; doi:10.1038/sj.clpt.6100498
See also: Macroscopy by LeshnerReducing the Harm of "Harm Reduction"
DJ Beirness, R Notarandrea, R Jesseman and M Perron
Clin Pharmacol Ther 83: 523-525; doi:10.1038/sj.clpt.6100509
See also: Macroscopy by LeshnerLetters to the Editor
Estrogens and Thrombosis
JJ Schrogie
Clin Pharmacol Ther 83: 526; doi:10.1038/clpt.2008.17
Upregulation of Multidrug Resistance-associated Protein 3 by Acetaminophen May Help to Increase Its Own Clearance
CI Ghanem and AD Mottino
Clin Pharmacol Ther 83: 527; doi:10.1038/sj.clpt.6100276
Response to "Upregulation of Multidrug Resistance-associated Protein 3 by Acetaminophen May Help to Increase Its Own Clearance"
CK Gelotte, JF Auiler, JM Lynch, AR Temple and JT Slattery
Clin Pharmacol Ther 83: 528; doi:10.1038/sj.clpt.6100302
Design of the "Thorough QT Study"
B Darpo and P Sager
Clin Pharmacol Ther 83: 529; doi:10.1038/sj.clpt.6100294
Response to "Design of the 'Thorough QT Study'"
J Morganroth
Clin Pharmacol Ther 83: 530; doi:10.1038/sj.clpt.6100299
State of the Art
State of the Art
Clinical Pharmacology of Nicotine: Implications for Understanding, Preventing, and Treating Tobacco Addiction
NL Benowitz
Clin Pharmacol Ther 83: 531-541; advance online publication, February 27, 2008; doi:10.1038/clpt.2008.3
Research
Articles
Microarray Analysis of the Global Alterations in the Gene Expression in the Placentas From Cigarette-smoking Mothers
P Huuskonen, M Storvik, M Reinisalo, P Honkakoski, J Rysä, J Hakkola and M Pasanen
Clin Pharmacol Ther 83: 542-550; advance online publication, October 27, 2007; doi:10.1038/sj.clpt.6100376
Potential Pharmacokinetic Basis for Zolpidem Dosing in Children With Sleep Difficulties
JL Blumer, MD Reed, F Steinberg, MA O'Riordan, CL Rosen, MA Springer, M Christensen and D Glaze for the NICHD PPRU Network
Clin Pharmacol Ther 83: 551-558; advance online publication, October 24, 2007; doi:10.1038/sj.clpt.6100380
Association of ABCB1/MDR1 and OPRM1 Gene Polymorphisms With Morphine Pain Relief
D Campa, A Gioia, A Tomei, P Poli and R Barale
Clin Pharmacol Ther 83: 559-566; advance online publication, September 26, 2007; doi:10.1038/sj.clpt.6100385
Effect of Human Renal Cationic Transporter Inhibition on the Pharmacokinetics of Varenicline, a New Therapy for Smoking Cessation: An In Vitro–In Vivo Study
B Feng, RS Obach, AH Burstein, DJ Clark, SM de Morais and HM Faessel
Clin Pharmacol Ther 83: 567-576; advance online publication, October 31, 2007; doi:10.1038/sj.clpt.6100405
Differential Opioid Action on Sensory and Affective Cerebral Pain Processing
BG Oertel, C Preibisch, T Wallenhorst, T Hummel, G Geisslinger, H Lanfermann and J Lötsch
Clin Pharmacol Ther 83: 577-588; advance online publication, November 21, 2007; doi:10.1038/sj.clpt.6100441
Articles
The CYP2A6*4 Allele Is Determinant of S-1 Pharmacokinetics in Japanese Patients With Non-small-cell Lung Cancer
Y Kaida, N Inui, T Suda, H Nakamura, H Watanabe and K Chida
Clin Pharmacol Ther 83: 589-594; advance online publication, January 23, 2008; doi:10.1038/sj.clpt.6100484
Articles
Pharmacokinetic and Pharmacodynamic Interaction of Lorazepam and Valproic Acid in Relation to UGT2B7 Genetic Polymorphism in Healthy Subjects
J-Y Chung, J-Y Cho, K-S Yu, J-R Kim, KS Lim, D-R Sohn, S-G Shin and I-J Jang
Clin Pharmacol Ther 83: 595-600; advance online publication, August 8, 2007; doi:10.1038/sj.clpt.6100324
Lopinavir–Ritonavir Dramatically Affects the Pharmacokinetics of Irinotecan in HIV Patients With Kaposi's Sarcoma
G Corona, E Vaccher, S Sandron, I Sartor, U Tirelli, F Innocenti and G Toffoli
Clin Pharmacol Ther 83: 601-606; advance online publication, August 22, 2007; doi:10.1038/sj.clpt.6100330
Articles
Human Abuse Liability of the Smoking Cessation Drug Varenicline in Smokers and Nonsmokers
SL McColl, AH Burstein, KR Reeves, CB Billing Jr, M Stolar and EM Sellers
Clin Pharmacol Ther 83: 607-614; advance online publication, February 20, 2008; doi:10.1038/sj.clpt.6100510
Discovery & Development
Discovery
Role of a Functional Human Gene Polymorphism in Stress Responsivity and Addictions
MJ Kreek
Clin Pharmacol Ther 83: 615-618; advance online publication, March 5, 2008; doi:10.1038/clpt.2008.5
Translational Medicine
Monoamine Oxidase Inhibition for Tobacco Pharmacotherapy
TP George and AH Weinberger
Clin Pharmacol Ther 83: 619-621; advance online publication, December 19, 2007; doi:10.1038/sj.clpt.6100474
Development
Assessing Abuse Liability During Drug Development: Changing Standards and Expectations
KA Schoedel and EM Sellers
Clin Pharmacol Ther 83: 622-626; advance online publication, January 23, 2008; doi:10.1038/sj.clpt.6100492
Potential of Buprenorphine/Naltrexone in Treating Polydrug Addiction and Co-occurring Psychiatric Disorders
DJ McCann
Clin Pharmacol Ther 83: 627-630; advance online publication, January 23, 2008; doi:10.1038/sj.clpt.6100503
Regulation & Use
Practice
Novel Methods for the Detection of Drug and Alcohol Exposure During Pregnancy:Implications for Maternal and Child Health
G. Koren, J. Hutson and J. Gareri
Clin Pharmacol Ther 83: 631-634; advance online publication, February 20, 2008; doi:10.1038/sj.clpt.6100506
Ethics
Anticipating Clinical Integration of Pharmacogenetic Treatment Strategies for Addiction: Are Primary Care Physicians Ready?
AE Shields and C Lerman
Clin Pharmacol Ther 83: 635-639; advance online publication, March 5, 2008; doi:10.1038/clpt.2008.4
public policy
Public Alcohol Policy: Current Directions and New Opportunities
J Rehm and TK Greenfield
Clin Pharmacol Ther 83: 640-643; advance online publication, February 27, 2008; doi:10.1038/sj.clpt.6100502
