Discovery
Clinical Pharmacology & Therapeutics (2008); 83, 4, 615–618. doi:10.1038/clpt.2008.5
Role of a Functional Human Gene Polymorphism in Stress Responsivity and Addictions
MJ Kreek1
1Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York, USA
Correspondence: MJ Kreek, (kreek@rockefeller.edu)
Received 9 November 2007; Accepted 4 January 2008; Published online 5 March 2008.
Abstract
Over the past decade, enormous progress has been made in both the technical approaches and the scientific information available for studying the human genome. Therefore, increasingly, scientists have begun to address not just single-gene disorders but complex disorders. The limiting factor in most of such studies remains appropriate, well-focused detailed phenotyping of the complex disorders under study, with careful ascertainment of subjects with the specific disorder, as well as healthy control subjects.
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