Innovations in Drug Development
TABLE OF CONTENTS
Volume 83, Issue 2 (February 2008)
Editorial |
News & Views |
Perspectives |
Research |
Discovery & Development |
Regulation & Use
In This Issue
In This Issue
In This Issue
Clin Pharmacol Ther 83: 197; doi:10.1038/sj.clpt.6100488
See also: Macroscopy by KaitinSee also: Articles by Shu et al. See also: Development by RobinsonSee also: Practice by AltarSee also: Public Policy by Altar et al.Editorial
Editorial
Back to the Future: Driving Innovation in Drug Development
JA Wagner
Clin Pharmacol Ther 83: 199-202; doi:10.1038/sj.clpt.6100477
News & Views
Highlights
News & Views
Clin Pharmacol Ther 83: 204-205; doi:10.1038/sj.clpt.6100489
ASCPT News
News & Views
Clin Pharmacol Ther 83: 206-207; doi:10.1038/sj.clpt.6100487
Books
Paediatric Drug Handling
Reviewed by MJ Kennedy
Clin Pharmacol Ther 83: 208-209; doi:10.1038/sj.clpt.6100430
Macroscopy
Obstacles and Opportunities in New Drug Development
KI Kaitin
Clin Pharmacol Ther 83: 210-212; doi:10.1038/sj.clpt.6100462
Perspectives
Point/Counterpoint
A New Look at the Profession of Clinical Pharmacology
MM Reidenberg
Clin Pharmacol Ther 83: 213-217; doi:10.1038/sj.clpt.6100424
Team-Centered Clinical Pharmacology Practice: Is It a Remedy for or the Basis of Our Discipline?
MD Reed
Clin Pharmacol Ther 83: 218-219; doi:10.1038/sj.clpt.6100456
Commentaries
Clinical Pharmacology in the Molecular Era
CT Dollery
Clin Pharmacol Ther 83: 220-225; doi:10.1038/sj.clpt.6100457
CYP2D6 Phenotype Prediction From Genotype: Which System Is the Best?
J Kirchheiner
Clin Pharmacol Ther 83: 225-227; doi:10.1038/sj.clpt.6100455
See also: Articles by Gaedigk et al.The State of Innovation in Drug Development
I Kola
Clin Pharmacol Ther 83: 227-230; doi:10.1038/sj.clpt.6100479
Forum
Thorough QT Study With Recommended and Supratherapeutic Doses of Tolterodine
B Olshansky and DB Serra
Clin Pharmacol Ther 83: 231-232; doi:10.1038/sj.clpt.6100328
Response to "Feedback to Tolterodine QT"
BK Malhotra and P Glue
Clin Pharmacol Ther 83: 233; doi:10.1038/sj.clpt.6100370
Research
Articles
The CYP2D6 Activity Score: Translating Genotype Information into a Qualitative Measure of Phenotype
A Gaedigk, SD Simon, RE Pearce, LD Bradford, MJ Kennedy and JS Leeder
Clin Pharmacol Ther 83: 234-242; advance online publication, October 31, 2007; doi:10.1038/sj.clpt.6100406
Effect of Atorvastatin on Energy Expenditure and Skeletal Muscle Oxidative Metabolism at Rest and During Exercise
J Chung, EP Brass, RG Ulrich and WR Hiatt
Clin Pharmacol Ther 83: 243-250; advance online publication, June 6, 2007; doi:10.1038/sj.clpt.6100264
Influence of OATP1B1 Genotype on the Pharmacokinetics of Rosuvastatin in Koreans
JH Choi, MG Lee, J-Y Cho, J-E Lee, KH Kim and K Park
Clin Pharmacol Ther 83: 251-257; advance online publication, June 13, 2007; doi:10.1038/sj.clpt.6100267
Expression of the Uptake Drug Transporter hOCT1 is an Important Clinical Determinant of the Response to Imatinib in Chronic Myeloid Leukemia
L Wang, A Giannoudis, S Lane, P Williamson, M Pirmohamed and RE Clark
Clin Pharmacol Ther 83: 258-264; advance online publication, June 13, 2007; doi:10.1038/sj.clpt.6100268
The Effect of Lopinavir/Ritonavir on the Renal Clearance of Tenofovir in HIV-infected Patients
JJ Kiser, ML Carten, CL Aquilante, PL Anderson, P Wolfe, TM King, T Delahunty, LR Bushman and CV Fletcher
Clin Pharmacol Ther 83: 265-272; advance online publication, June 27, 2007; doi:10.1038/sj.clpt.6100269
Effect of Genetic Variation in the Organic Cation Transporter 1, OCT1, on Metformin Pharmacokinetics
Y Shu, C Brown, RA Castro, RJ Shi, ET Lin, RP Owen, SA Sheardown, L Yue, EG Burchard, CM Brett and KM Giacomini
Clin Pharmacol Ther 83: 273-280; advance online publication, July 4, 2007; doi:10.1038/sj.clpt.6100275
Stimulation of Cholecystokinin-A Receptors With GI181771X does not Cause Weight Loss in Overweight or Obese Patients
J Jordan, FL Greenway, LA Leiter, Z Li, P Jacobson, K Murphy, J Hill, L Kler and RP Aftring
Clin Pharmacol Ther 83: 281-287; advance online publication, June 27, 2007; doi:10.1038/sj.clpt.6100272
Cytochrome P450 2C9 *2 and *3 Polymorphisms and the Dose and Effect of Sulfonylurea in Type II Diabetes Mellitus
ML Becker, LE Visser, PH Trienekens, A Hofman, RHN van Schaik and BHCh Stricker
Clin Pharmacol Ther 83: 288-292; advance online publication, June 27, 2007; doi:10.1038/sj.clpt.6100273
Safety, Tolerability, and Pharmacokinetics of Raltegravir After Single and Multiple Doses in Healthy Subjects
M Iwamoto, LA Wenning, AS Petry, M Laethem, M De Smet, JT Kost, SA Merschman, KM Strohmaier, S Ramael, KC Lasseter, JA Stone, KM Gottesdiener and JA Wagner
Clin Pharmacol Ther 83: 293-299; advance online publication, August 22, 2007; doi:10.1038/sj.clpt.6100281
Pharmacokinetics and Pharmacodynamics of Efavirenz and Nelfinavir in HIV-infected Children Participating in an Area-under-the-curve Controlled Trial
CV Fletcher, RC Brundage, T Fenton, CG Alvero, C Powell, LM Mofenson and SA Spector
Clin Pharmacol Ther 83: 300-306; advance online publication, July 4, 2007; doi:10.1038/sj.clpt.6100282
Effect of Upper Respiratory Tract Infection on AIR Inhaled Insulin Pharmacokinetics and Glucodynamics in Healthy Subjects
JE Gern, CK Stone, M Nakano, DB Muchmore, A de la Peña, S Park, A Suri, F Tibaldi, D Soon and WW Busse
Clin Pharmacol Ther 83: 307-311; advance online publication, July 11, 2007; doi:10.1038/sj.clpt.6100286
Influence of CYP2C9 and VKORC1 1173C/T Genotype on the Risk of Hemorrhagic Complications in African-American and European-American Patients on Warfarin
NA Limdi, G McGwin, JA Goldstein, TM Beasley, DK Arnett, BK Adler, MF Baird and RT Acton
Clin Pharmacol Ther 83: 312-321; advance online publication, July 25, 2007; doi:10.1038/sj.clpt.6100290
Impact of the Ultrarapid CYP2C19*17 Allele on Serum Concentration of Escitalopram in Psychiatric Patients
I Rudberg, B Mohebi, M Hermann, H Refsum and E Molden
Clin Pharmacol Ther 83: 322-327; advance online publication, July 11, 2007; doi:10.1038/sj.clpt.6100291
Expression of Inosine Monophosphate Dehydrogenase Type I and Type II After Mycophenolate Mofetil Treatment: A 2-year Follow-up in Kidney Transplantation
S Sanquer, P Maison, C Tomkiewicz, I Macquin-Mavier, C Legendre, R Barouki and P Lang
Clin Pharmacol Ther 83: 328-335; advance online publication, August 22, 2007; doi:10.1038/sj.clpt.6100300
Endothelium-mediated Modulation of Ergoreflex and Improvement in Exercise Ventilation by Acute Sildenafil in Heart Failure Patients
M Guazzi, M Casali, F Berti, G Rossoni, V D'Gennaro Colonna and MD Guazzi
Clin Pharmacol Ther 83: 336-341; advance online publication, July 25, 2007; doi:10.1038/sj.clpt.6100306
Effect of Terbinafine and Voriconazole on the Pharmacokinetics of the Antidepressant Venlafaxine
V-V Hynninen, KT Olkkola, L Bertilsson, K Kurkinen, PJ Neuvonen and K Laine
Clin Pharmacol Ther 83: 342-348; advance online publication, August 8, 2007; doi:10.1038/sj.clpt.6100311
Discovery & Development
Discovery
The Role of Molecular Imaging in Drug Discovery and Development
RJ Hargreaves
Clin Pharmacol Ther 83: 349-353; advance online publication, January 2, 2008; doi:10.1038/sj.clpt.6100467
Translational Medicine
KATP Channel Pharmacogenomics: From Bench to Bedside
S Sattiraju, S Reyes, GC Kane and A Terzic
Clin Pharmacol Ther 83: 354-357; advance online publication, October 24, 2007; doi:10.1038/sj.clpt.6100378
Development
Innovative Early Development Regulatory Approaches: expIND, expCTA, Microdosing
WT Robinson
Clin Pharmacol Ther 83: 358-360; advance online publication, December 19, 2007; doi:10.1038/sj.clpt.6100461
Regulation & Use
Practice
The Biomarkers Consortium: On the Critical Path of Drug Discovery
CA Altar
Clin Pharmacol Ther 83: 361-364; advance online publication, January 9, 2008; doi:10.1038/sj.clpt.6100471
Ethics
High-risk Molecules or Insufficient Scientific Data?
A Mignot
Clin Pharmacol Ther 83: 365-367; advance online publication, December 19, 2007; doi:10.1038/sj.clpt.6100460
Public Policy
A Prototypical Process for Creating Evidentiary Standards for Biomarkers and Diagnostics
CA Altar, D Amakye, D Bounos, J Bloom, G Clack, R Dean, V Devanarayan, D Fu, S Furlong, L Hinman, C Girman, C Lathia, L Lesko, S Madani, J Mayne, J Meyer, D Raunig, P Sager, SA Williams, P Wong and K Zerba
Clin Pharmacol Ther 83: 368-371; advance online publication, December 19, 2007; doi:10.1038/sj.clpt.6100451
