Global Health

TABLE OF CONTENTS

Volume 82, Issue 5 (November 2007)

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Contents

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Editorial

Individualized Medicine and the Imperative of Global Health

S A Waldman and A Terzic

Clin Pharmacol Ther 82: 479-483; doi:10.1038/sj.clpt.6100398

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News and Views

Highlights

News and Views

Clin Pharmacol Ther 82: 484-485; doi:10.1038/sj.clpt.6100411

ASCPT News

ASCPT News

Clin Pharmacol Ther 82: 486-487; doi:10.1038/sj.clpt.6100413

Macroscopy

Should the Patent System for New Medicines Be Abolished?

J A DiMasi and H G Grabowski

Clin Pharmacol Ther 82: 488-490; doi:10.1038/sj.clpt.6100393

A Vision of Individualized Medicine in the Context of Global Health FREE

D A Cortese

Clin Pharmacol Ther 82: 491-493; doi:10.1038/sj.clpt.6100390

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Perspectives

Commentaries

Does Clinical Pharmacology & Therapeutics' Conflict of Interest Policy Protect the Reader?

M H Conway

Clin Pharmacol Ther 82: 495-496; doi:10.1038/sj.clpt.6100387

See also: Commentary by
Clinical Pharmacology & Therapeutics' Conflict of Interest Policy

Clin Pharmacol Ther 82: 496-497; doi:10.1038/sj.clpt.6100414

See also: Commentary by Conway
The Essential Medicines List for a Global Patient Population FREE

J Robertson and S R Hill

Clin Pharmacol Ther 82: 498-500; doi:10.1038/sj.clpt.6100392

Essential Medicines for the Whole World

M M Reidenberg

Clin Pharmacol Ther 82: 500-503; doi:10.1038/sj.clpt.6100388

Access to Essential Medicines for Children: The World Health Organization's Global Response

H Zucker and L Rägo

Clin Pharmacol Ther 82: 503-505; doi:10.1038/sj.clpt.6100395

Dosing in Obesity: A Simple Solution to a Big Problem

P Y Han, S B Duffull, C M J Kirkpatrick and B Green

Clin Pharmacol Ther 82: 505-508; doi:10.1038/sj.clpt.6100381

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State of the Art

State of the Art

Metabolic Syndrome: From Global Epidemiology to Individualized Medicine

J A Batsis, R E Nieto-Martinez and F Lopez-Jimenez

Clin Pharmacol Ther 82: 509-524; advance online publication, September 12, 2007; doi:10.1038/sj.clpt.6100355

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Research

Articles

Presynaptic alpha-2C Adrenoceptor-mediated Control of Noradrenaline Release in Humans: Genotype- or Age-Dependent?

H Bruck, T Schwerdtfeger, M Toliat, K Leineweber, G Heusch, T Philipp, P Nürnberg and O-E Brodde

Clin Pharmacol Ther 82: 525-530; advance online publication, April 4, 2007; doi:10.1038/sj.clpt.6100181

Development of the "Inje Cocktail" for High-throughput Evaluation of Five Human Cytochrome P450 Isoforms in vivo

J Y Ryu, I S Song, Y E Sunwoo, J H Shon, K H Liu, I J Cha and J G Shin

Clin Pharmacol Ther 82: 531-540; advance online publication, March 28, 2007; doi:10.1038/sj.clpt.6100187

SLCO1B1 (OATP1B1, an Uptake Transporter) and ABCG2 (BCRP, an Efflux Transporter) Variant Alleles and Pharmacokinetics of Pitavastatin in Healthy Volunteers

I Ieiri, S Suwannakul, K Maeda, H Uchimaru, K Hashimoto, M Kimura, H Fujino, M Hirano, H Kusuhara, S Irie, S Higuchi and Y Sugiyama

Clin Pharmacol Ther 82: 541-547; advance online publication, April 25, 2007; doi:10.1038/sj.clpt.6100190

Comparison of the Effects of Thioridazine and Mesoridazine on the QT Interval in Healthy Adults After Single Oral Doses

I S M Salih, R H K Thanacoody, G A McKay and S H L Thomas

Clin Pharmacol Ther 82: 548-554; advance online publication, April 4, 2007; doi:10.1038/sj.clpt.6100194

See also: Article by Thanacoody et al.
Factors Affecting Drug Concentrations and QT Interval During Thioridazine Therapy

R H K Thanacoody, A K Daly, J G Reilly, I N Ferrier and S H L Thomas

Clin Pharmacol Ther 82: 555-565; advance online publication, April 25, 2007; doi:10.1038/sj.clpt.6100195

See also: Article by Salih et al.
Clinical Pharmacology Information in Summaries of Product Characteristics and Package Inserts

B Arguello and F Fernandez-Llimos

Clin Pharmacol Ther 82: 566-571; advance online publication, April 4, 2007; doi:10.1038/sj.clpt.6100198

Vaporization as a Smokeless Cannabis Delivery System: A Pilot Study

D I Abrams, H P Vizoso, S B Shade, C Jay, M E Kelly and N L Benowitz

Clin Pharmacol Ther 82: 572-578; advance online publication, April 11, 2007; doi:10.1038/sj.clpt.6100200

Cytochrome P450 3A5 Genotype is Associated with Verapamil Response in Healthy Subjects

Y Jin, Y-H Wang, J Miao, L Li, R J Kovacs, R Marunde, M A Hamman, S Phillips, J Hilligoss and S D Hall

Clin Pharmacol Ther 82: 579-585; advance online publication, April 18, 2007; doi:10.1038/sj.clpt.6100208

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Discovery & Development

Discovery

Molecular Systems Biology in Drug Development

P A Silver and J C Way

Clin Pharmacol Ther 82: 586-590; advance online publication, July 18, 2007; doi:10.1038/sj.clpt.6100293

Endocannabinoid System and Cardiometabolic Risk FREE

L E Saavedra

Clin Pharmacol Ther 82: 591-594; advance online publication, September 26, 2007; doi:10.1038/sj.clpt.6100373

Translational Medicine

Advances in the Treatment of Tuberculosis

Y Zhang

Clin Pharmacol Ther 82: 595-600; advance online publication, September 26, 2007; doi:10.1038/sj.clpt.6100362

Development

Pharmacologic Advances in the Global Control and Treatment of Malaria: Combination Therapy and Resistance

M M Nyunt and C V Plowe

Clin Pharmacol Ther 82: 601-605; advance online publication, September 26, 2007; doi:10.1038/sj.clpt.6100361

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Regulation & Use

Practice

Metabolism of Antidepressant and Neuroleptic Drugs by Cytochrome P450s: Clinical and Interethnic Aspects

L Bertilsson

Clin Pharmacol Ther 82: 606-609; advance online publication, September 26, 2007; doi:10.1038/sj.clpt.6100358

Ethics

The Morally Uncomfortable Global Drug Gap FREE

J C Cohen-Kohler

Clin Pharmacol Ther 82: 610-614; advance online publication, September 26, 2007; doi:10.1038/sj.clpt.6100359

Education

Professional Students' Perceptions of the Value, Role, and Impact of Science in Clinical Education

Z Austin and P A M Gregory

Clin Pharmacol Ther 82: 615-620; advance online publication, July 4, 2007; doi:10.1038/sj.clpt.6100274

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