Commentary
Clinical Pharmacology & Therapeutics (2007) 82, 244–248. doi:10.1038/sj.clpt.6100284
The Star-Allele Nomenclature: Retooling for Translational Genomics
J D Robarge1, L Li1, Z Desta2, A Nguyen2 and D A Flockhart2
- 1Division of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, USA
- 2Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
Correspondence: JD Robarge, (jrobarge@iupui.edu)
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Abstract
The star-allele nomenclature is the result of efforts to standardize genetic polymorphism annotation for the cytochrome P450 genes. As clinical pharmacogenetic testing becomes widespread, it is important that this system effectively communicate a patient's genotype and predicted clinical phenotype. As genomics research expands, it is equally important that the system remain a valuable tool for the wider community of genetic researchers to exploit our ever-improving ability to catalog variability in the human genome.
