State-of-the-art treatment for diabetes
To effectively treat the individual with type 2 diabetes, the provider must have a thorough understanding of the underlying pathophysiology. The newer treatments available, specifically incretin therapy, enhance the ability to modulate insulin release and glucose metabolism. The currently available agents can be combined to markedly improve glycemic control and allow the provider to design regimens to specifically address underlying abnormalities. See page 636
Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes
This article focuses on the physiology, clinical pharmacology, tolerability, and clinical usefulness of the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin in the management of type 2 diabetes. DPP-4 inhibitors represent a new class of oral antihyperglycemic agents to treat patients with type 2 diabetes. See page 761
Treatments for the prevention of diabetes mellitus
Much research effort has been expended to identify individuals at risk of type 1 diabetes mellitus. Prediction of development of type 1 diabetes is based on risk assessment, which is accomplished using genetic, immunologic, and metabolic parameters. See page 768
The role of public policy in treating obesity
The author reviews the potential use of policy to stem the global epidemic of obesity. What has been missing from current efforts is a strategy that recognizes and deals with the ubiquitous economic, environmental, and cultural forces promoting positive energy balance and weight gain. See page 772
Lifestyle modification in the treatment of obesity
Two-thirds of the US population suffer from weight-related comorbidities such as hypertension, hyperlipidemia, and type 2 diabetes. This article describes the behavioral treatment of obesity, including its short- and long-term results as well as approaches to avoiding the regaining of lost weight. See page 776
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