Maternal and Child Health

TABLE OF CONTENTS

Volume 81, Issue 4 (April 2007)

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Contents

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Editorial

Editorial

Clinical Pharmacology: A Discipline Called to Action for Maternal and Child Health

G L Kearns, W A Ritschel, J T Wilson and S P Spielberg

Clin Pharmacol Ther 81: 463-468; doi:10.1038/sj.clpt.6100145

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News and Views

Highlights

Highlights

Clin Pharmacol Ther 81: 470-471; doi:10.1038/sj.clpt.6100158

ASCPT News

ASCPT News

Clin Pharmacol Ther 81: 472-473; doi:10.1038/sj.clpt.6100137

Books

Minor Illness or Major Disease? The Clinical Pharmacist in the Community, 4th edn.

M D Reed

Clin Pharmacol Ther 81: 474-475; doi:10.1038/sj.clpt.6100132

Macroscopy

Future of Pediatric Therapeutics: Reauthorization of BPCA and PREA

R M Ward and R Kauffman

Clin Pharmacol Ther 81: 477-479; doi:10.1038/sj.clpt.6100109

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Perspectives

Commentaries

"To Care": A Visual Inspiration for Maternal and Child Health

W A Ritschel

Clin Pharmacol Ther 81: 480-481; doi:10.1038/sj.clpt.6100110

Obstetric Clinical Pharmacology: Coming of Age

A Zajicek and G P Giacoia

Clin Pharmacol Ther 81: 481-482; doi:10.1038/sj.clpt.6100136

See also: Article by Andrew et al.
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State of the Art

State of the Art

Considerations in the Rational Design and Conduct of Phase I/II Pediatric Clinical Trials: Avoiding the Problems and Pitfalls

S M Abdel-Rahman, M D Reed, T G Wells and G L Kearns

Clin Pharmacol Ther 81: 483-494; advance online publication, February 28, 2007; doi:10.1038/sj.clpt.6100134

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Research

Articles

Naringin is a Major and Selective Clinical Inhibitor of Organic Anion-Transporting Polypeptide 1A2 (OATP1A2) in Grapefruit Juice

D G Bailey, G K Dresser, B F Leake and R B Kim

Clin Pharmacol Ther 81: 495-502; advance online publication, February 14, 2007; doi:10.1038/sj.clpt.6100104

The Effects of Tadalafil on Cold-induced Vasoconstriction in Patients with Raynaud's Phenomenon

E A Friedman, P A Harris, A J J Wood, C M Stein and D Kurnik

Clin Pharmacol Ther 81: 503-509; advance online publication, February 14, 2007; doi:10.1038/sj.clpt.6100103

Ontogeny of Dextromethorphan O- and N-demethylation in the First Year of Life

M J Blake, A Gaedigk, R E Pearce, L R Bomgaars, M L Christensen, C Stowe, L P James, J T Wilson, G L Kearns and J S Leeder

Clin Pharmacol Ther 81: 510-516; advance online publication, February 14, 2007; doi:10.1038/sj.clpt.6100101

Age-dependent Pharmacokinetics of Lamivudine in HIV-infected Children

D M Burger, G Verweel, N Rakhmanina, C P W G M Verwey-Van Wissen, C J L La Porte, A S Bergshoeff, H Lyall, N G Hartwig, H Green, S Soldin, D M Gibb and R de Groot

Clin Pharmacol Ther 81: 517-520; advance online publication, February 28, 2007; doi:10.1038/sj.clpt.6100118

Pharmacogenomics-based Tailored Versus Standard Therapeutic Regimen for Eradication of H. pylori

T Furuta, N Shirai, M Kodaira, M Sugimoto, A Nogaki, S Kuriyama, M Iwaizumi, M Yamade, I Terakawa, K Ohashi, T Ishizaki and A Hishida

Clin Pharmacol Ther 81: 521-528; advance online publication, January 10, 2007; doi:10.1038/sj.clpt.6100043

A PK–PD Model for Predicting the Impact of Age, CYP2C9, and VKORC1 Genotype on Individualization of Warfarin Therapy

A-K Hamberg, M-L Dahl, M Barban, M G Scordo, M Wadelius, V Pengo, R Padrini and E N Jonsson

Clin Pharmacol Ther 81: 529-538; advance online publication, February 14, 2007; doi:10.1038/sj.clpt.6100084

Genetic Polymorphisms in the ABCB1 Gene and the Effects of Fentanyl in Koreans

H-J Park, H K Shinn, S H Ryu, H-S Lee, C-S Park and J-H Kang

Clin Pharmacol Ther 81: 539-546; advance online publication, December 27, 2006; doi:10.1038/sj.clpt.6100046

Amoxicillin Pharmacokinetics in Pregnant Women: Modeling and Simulations of Dosage Strategies

M A Andrew, T R Easterling, D B Carr, D Shen, M L Buchanan, T Rutherford, R Bennett, P Vicini and M F Hebert

Clin Pharmacol Ther 81: 547-556; advance online publication, February 28, 2007; doi:10.1038/sj.clpt.6100126

Predictive Value of Known and Novel Alleles of CYP2B6 for Efavirenz Plasma Concentrations in HIV-infected Individuals

M Rotger, H Tegude, S Colombo, M Cavassini, H Furrer, L Décosterd, J Blievernicht, T Saussele, H F Günthard, M Schwab, M Eichelbaum, A Telenti and U M Zanger

Clin Pharmacol Ther 81: 557-566; advance online publication, January 18, 2007; doi:10.1038/sj.clpt.6100072

Developmental Changes of Aldehyde Oxidase Activity in Young Japanese Children

Y Tayama, K Miyake, K Sugihara, S Kitamura, M Kobayashi, S Morita, S Ohta and K Kihira

Clin Pharmacol Ther 81: 567-572; doi:10.1038/sj.clpt.6100078

Pharmacokinetic Parameters of Sulfated Tibolone Metabolites in Postmenopausal Women after Single and Multiple Doses of Tibolone

H A M Verheul, C J Timmer and H J Kloosterboer

Clin Pharmacol Ther 81: 573-579; advance online publication, February 14, 2007; doi:10.1038/sj.clpt.6100094

Effect of Rosiglitazone on Visfatin and Retinol-Binding Protein-4 Plasma Concentrations in HIV-Positive Patients

D G Haider, K Schindler, F Mittermayer, M Müller, P Nowotny, A Rieger, A Luger, B Ludvik and M Wolzt

Clin Pharmacol Ther 81: 580-585; advance online publication, January 18, 2007; doi:10.1038/sj.clpt.6100047

Risk of Extrapyramidal Syndrome in Schizophrenic Patients Treated with Antipsychotics: A Population-based Study

S-Y Yang, Y-H Kao Yang, M-Y Chong, Y-H Yang, W-H Chang and C-S Lai

Clin Pharmacol Ther 81: 586-594; advance online publication, January 18, 2007; doi:10.1038/sj.clpt.6100069

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Discovery & Development

Translational Medicine

Application of Pharmacogenomic Strategies to the Study of Drug-induced Birth Defects

J S Leeder and A A Mitchell

Clin Pharmacol Ther 81: 595-599; advance online publication, February 21, 2007; doi:10.1038/sj.clpt.6100128

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Regulation & Use

Development

Females in Clinical Studies: Where are We Going?

K Uhl, A Parekh and S Kweder

Clin Pharmacol Ther 81: 600-602; advance online publication, February 21, 2007; doi:10.1038/sj.clpt.6100112

World Health Organization Program for the Selection and Use of Essential Medicines

M M Reidenberg

Clin Pharmacol Ther 81: 603-606; advance online publication, February 21, 2007; doi:10.1038/sj.clpt.6100106

Practice

Human Papillomavirus Infection: The Role of Vaccination in Pediatric Patients

J R Nichols, S H Stovall and R F Jacobs

Clin Pharmacol Ther 81: 607-610; advance online publication, February 21, 2007; doi:10.1038/sj.clpt.6100108

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Corrigendum

CORRIGENDUM: Effect of Rosiglitazone on Visfatin and Retinol-binding Protein-4 Plasma Concentrations in HIV-positive Patients FREE

D G Haider, K Schindler, F Mittermayer, M Müller, P Nowotny, A Rieger, A Luger, B Ludvik and M Wolzt

Clin Pharmacol Ther 81: 611; doi:10.1038/sj.clpt.6100182

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