TABLE OF CONTENTS

Volume 80, Issue 6 (December 2006)

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Perspectives in Clinical Pharmacology

Drug interactions with lipid-lowering drugs: Mechanisms and clinical relevance

Pertti J. Neuvonen MD, Mikko Niemi MD and Janne T. Backman MD

Clin Pharmacol Ther 80: 565-581; doi:10.1016/j.clpt.2006.09.003

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Pharmacokinetics and Drug Disposition

Sulfadoxine-pyrimethamine pharmacokinetics in malaria: Pediatric dosing implications

Karen I. Barnes MBChB, MMed, Francesca Little PhD, Peter J. Smith PhD, Alicia Evans Dip Med Tech, William M. Watkins PhD and Nicholas J. White DSc, FRS

Clin Pharmacol Ther 80: 582-596; doi:10.1016/j.clpt.2006.08.016

Differential effect of chronic renal failure on the pharmacokinetics of lidocaine in patients receiving and not receiving hemodialysis

Sara De Martin PhD, Rocco Orlando MD, Massimo Bertoli MD, Paola Pegoraro PhD and Pietro Palatini PhD

Clin Pharmacol Ther 80: 597-606; doi:10.1016/j.clpt.2006.08.020

Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart

Markus Grube PhD, Kathleen Köck MSc, Stefan Oswald MSc, Katrin Draber, Konrad Meissner MD, Lothar Eckel MD, Michael Böhm MD, Stephan B. Felix MD, Silke Vogelgesang MD, Gabriele Jedlitschky PhD, Werner Siegmund MD, Rolf Warzok MD and Heyo K. Kroemer PhD

Clin Pharmacol Ther 80: 607-620; doi:10.1016/j.clpt.2006.09.010

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Pharmacogenetics and Genomics

The cyclooxygenase 2 genetic variant -765G>C does not modulate the effects of celecoxib on prostaglandin E2 production

Carsten Skarke MD, Maximilian Reus, Ronald Schmidt, Inga Grundei, Patrick Schuss, Gerd Geisslinger MD, PhD and Jörn Lötsch MD, PhD

Clin Pharmacol Ther 80: 621-632; doi:10.1016/j.clpt.2006.08.021

beta2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension

Guido Iaccarino MD, PhD, Raffaele Izzo MD, PhD, Valentina Trimarco PhD, Ersilia Cipolletta MD, Francesca Lanni MD, Daniela Sorriento BS, Gianni Luigi Iovino MD, PhD, Francesco Rozza MD, PhD, Nicola De Luca MD, Ornella Priante MD, Gianfranco Di Renzo MD and Bruno Trimarco MD

Clin Pharmacol Ther 80: 633-645; doi:10.1016/j.clpt.2006.09.006

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Correction

Correction FREE

Clin Pharmacol Ther 80: 645; doi:10.1016/j.clpt.2006.09.014

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Pharmacogenetics and Genomics

Effect of CYP3A5*3 genotype on the pharmacokinetics and pharmacodynamics of amlodipine in healthy Korean subjects

Kyoung-Ah Kim PhD, Pil-Whan Park MD, PhD, Ock-Je Lee BS, Sang-Hyun Choi MD, PhD, Bon Hong Min PhD, Kyung-Ho Shin MD, PhD, Boe-Gwun Chun MD, PhD, Jae-Gook Shin MD, PhD and Ji-Young Park MD, PhD

Clin Pharmacol Ther 80: 646-656; doi:10.1016/j.clpt.2006.09.009

Pharmacokinetics and pharmacodynamics of rosiglitazone in relation to CYP2C8 genotype

Julia Kirchheiner MD, PhD, Soju Thomas MD, Steffen Bauer PhD, Dorota Tomalik-Scharte MD, Ursula Hering MD, Oxana Doroshyenko MSc, Alexander Jetter MD, Simone Stehle MSc, Martina Tsahuridu MD, Ingolf Meineke PhD, Jürgen Brockmöller MD, PhD and Uwe Fuhr MD, PhD

Clin Pharmacol Ther 80: 657-667; doi:10.1016/j.clpt.2006.09.008

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Correction

Correction FREE

Clin Pharmacol Ther 80: 667; doi:10.1016/j.clpt.2006.05.001

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Pharmacogenetics and Genomics

ABCB1 and cytochrome P450 genotypes and phenotypes: Influence on methadone plasma levels and response to treatment

Séverine Crettol, Jean-Jacques Déglon MD, Jacques Besson MD, Marina Croquette-Krokar MD, Robert Hämmig MD, Isabelle Gothuey MD, Martine Monnat MD and Chin B. Eap PhD

Clin Pharmacol Ther 80: 668-681; doi:10.1016/j.clpt.2006.09.012

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Correction

Correction FREE

Clin Pharmacol Ther 80: 681; doi:10.1016/j.clpt.2006.11.001

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Pharmacogenetics and Genomics

ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals

Janet K. Coller PhD, Daniel T. Barratt BSc(Hon), Karianne Dahlen MSc, Morten H. Loennechen MSc and Andrew A. Somogyi PhD

Clin Pharmacol Ther 80: 682-690; doi:10.1016/j.clpt.2006.09.011

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Correction

Correction FREE

Clin Pharmacol Ther 80: 690; doi:10.1016/j.clpt.2006.10.002

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Pharmacodynamics and Drug Action

Direct and rapid inhibition of factor Xa by otamixaban: A pharmacokinetic and pharmacodynamic investigation in patients with coronary artery disease

Markus Hinder MD, Annke Frick PhD, Pierre Jordaan MD, Galina Hesse MSc, Alexander Gebauer MD, Jochen Maas PhD and Anne Paccaly PhD

Clin Pharmacol Ther 80: 691-702; doi:10.1016/j.clpt.2006.09.002

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Correction

Correction FREE

Clin Pharmacol Ther 80: 702; doi:10.1016/j.clpt.2006.10.001

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Clinical Trials

Nicotine intake and dose response when smoking reduced–nicotine content cigarettes

Neal L. Benowitz MD, Peyton Jacob III PhD and Brenda Herrera

Clin Pharmacol Ther 80: 703-714; doi:10.1016/j.clpt.2006.09.007

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Letter to the Editor

Comment on severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency

Rhys Whomsley PhD, Margherita Strolin-Benedetti PhD and Eugène Baltes Ing Bioch

Clin Pharmacol Ther 80: 715-716; doi:10.1016/j.clpt.2006.08.018

Reply

Shuichi Tsuruoka MD, Takashi Ioka MD, Michi Wakaumi MD, Akio Fujimura MD, Koh-ichi Sakamoto PharmD and Hitoshi Ookami MD

Clin Pharmacol Ther 80: 716-717; doi:10.1016/j.clpt.2006.08.019

Drug interaction of tizanidine and ciprofloxacin: Case report

Kenji Momo MS, Masato Homma PhD, Yukinao Kohda PhD, Norio Ohkoshi MD, Toshihiro Yoshizawa MD and Akira Tamaoka MD

Clin Pharmacol Ther 80: 717-719; doi:10.1016/j.clpt.2006.08.017

CYP3A5 polymorphism and alprazolam pharmacokinetics/pharmacodynamics

Karthik Venkatakrishnan PhD and Megan A. Gibbs PhD

Clin Pharmacol Ther 80: 719-720; doi:10.1016/j.clpt.2006.09.013

Reply

Ji-Young Park MD, Kyoung-Ah Kim PhD and Jae-Gook Shin MD, PhD

Clin Pharmacol Ther 80: 720; doi:10.1016/j.clpt.2006.08.022

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Guest Reviewers

Guest Reviewers

Clin Pharmacol Ther 80: 721-723; doi:10.1016/j.clpt.2006.09.005

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Books Received

Books received

Clin Pharmacol Ther 80: 724; doi:10.1016/j.clpt.2006.09.004

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Editorial Board

Editorial Board for index

Clin Pharmacol Ther 80: 737; doi:10.1016/S0009-9236(06)00487-5

Copyright page for index

Clin Pharmacol Ther 80: 738; doi:10.1016/S0009-9236(06)00488-7

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Author Index

Author Index

Clin Pharmacol Ther 80: 739-744; doi:10.1016/S0009-9236(06)00489-9

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Subject Index

Subject Index

Clin Pharmacol Ther 80: 745-755; doi:10.1016/S0009-9236(06)00490-5

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