FIGURES AND TABLES

Figure 1.

Pharmacokinetic and pharmacodynamic data from a subject expressing the CYP2C9*3/*3 genotype after administration of single doses of piroxicam (20 mg orally) on 2 different occasions, separated by 6 months. Blood samples were collected at various time intervals for 312 hours and for 2784 hours after administration of the first dose (open squares) and second dose (solid squares), respectively. Plasma concentration–time curves of piroxicam are presented (A), as well as serum concentration–time curves of prostaglandin E₂ (PGE₂) (B) and thromboxane B₂ (TxB₂) (C); the PGE₂ and TXB₂ data are normalized to the baseline serum PGE₂ and TXB₂ concentrations, measured 24 hours (first dose) and 24 to 72 hours (second dose) before each drug administration.