TABLE OF CONTENTS

Volume 80, Issue 4 (October 2006)

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Pharmacogenetics and Genomics

Orosomucoid (alpha1-acid glycoprotein) plasma concentration and genetic variants: Effects on human immunodeficiency virus protease inhibitor clearance and cellular accumulation

Sara Colombo PhD, Thierry Buclin MD, Laurent A. Décosterd PhD, Amalio Telenti MD, Hansjakob Furrer MD, Belle L. Lee PharmD, Jérôme Biollaz MD and Chin B. Eap PhD Swiss HIV Cohort Study

Clin Pharmacol Ther 80: 307-318; doi:10.1016/j.clpt.2006.06.006

Determinants of the rate of nicotine metabolism and effects on smoking behavior

Elaine Johnstone PhD, Neal Benowitz PhD, Anna Cargill MSc, Robyn Jacob BSc, Lesley Hinks FIMLS, Ian Day PhD, Mike Murphy MSc and Robert Walton MD

Clin Pharmacol Ther 80: 319-330; doi:10.1016/j.clpt.2006.06.011

Population pharmacokinetic and pharmacogenomic analysis of tacrolimus in pediatric living-donor liver transplant recipients

Masahide Fukudo MS, Ikuko Yano PhD, Satohiro Masuda PhD, Maki Goto PhD, Miwa Uesugi BS, Toshiya Katsura PhD, Yasuhiro Ogura MD, Fumitaka Oike MD, Yasutsugu Takada MD, Hiroto Egawa MD, Shinji Uemoto MD and Ken-ichi Inui PhD

Clin Pharmacol Ther 80: 331-345; doi:10.1016/j.clpt.2006.06.008

A warfarin-dosing model in Asians that uses single-nucleotide polymorphisms in vitamin K epoxide reductase complex and cytochrome P450 2C9

Lai-San Tham PharmD, Boon-Cher Goh MD, Anne Nafziger MD, MHS, Jia-Yi Guo MSc, Ling-Zhi Wang MSc, Richie Soong PhD and Soo-Chin Lee MD

Clin Pharmacol Ther 80: 346-355; doi:10.1016/j.clpt.2006.06.009

SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin

Mikko Niemi MD, Marja K. Pasanen MB and Pertti J. Neuvonen MD

Clin Pharmacol Ther 80: 356-366; doi:10.1016/j.clpt.2006.06.010

MDR1 gene polymorphisms are associated with neuropsychiatric adverse effects of mefloquine

Albert L. H. J. Aarnoudse MD, Ron H. N. van Schaik PhD, Jeanne Dieleman PhD, Mariam Molokhia PhD, Melanie M. van Riemsdijk PhD, Robert J. Ligthelm MD, PhD, David Overbosch MD, PhD, Ilse P. van der Heiden and Bruno H. Ch. Stricker PhD

Clin Pharmacol Ther 80: 367-374; doi:10.1016/j.clpt.2006.07.003

The thiopurine methyltransferase genetic polymorphism is associated with thioguanine-related veno-occlusive disease of the liver in children with acute lymphoblastic leukemia

Lynne Lennard PhD, Sue Richards DPhil, Cher S. Cartwright BSc, Chris Mitchell PhD, FRCP, John S. Lilleyman DSc, FRCPath and Ajay Vora FRCPath UK MRC/NCRI Childhood Leukaemia Working Party

Clin Pharmacol Ther 80: 375-383; doi:10.1016/j.clpt.2006.07.002

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Pharmacokinetics and Drug Disposition

A pharmacokinetic-based test to prevent severe 5-fluorouracil toxicity

Guido Bocci MD, PhD, Cecilia Barbara MD, Francesca Vannozzi MD, Antonello Di Paolo MD, PhD, Alessandro Melosi MD, Gemma Barsanti MD, Giacomo Allegrini MD, Alfredo Falcone MD, Mario Del Tacca MD, PharmD and Romano Danesi MD, PhD

Clin Pharmacol Ther 80: 384-395; doi:10.1016/j.clpt.2006.06.007

Low hepatic cytochrome P450 3A activity is a risk for corticosteroid-induced osteonecrosis

Yasunori Kaneshiro MD, Yutaka Oda MD, PhD, Kentaro Iwakiri MD, Toshiaki Masada MD, Hiroyoshi Iwaki MD, PhD, Yoshio Hirota MD, PhD, Kyoko Kondo BSc and Kunio Takaoka MD, PhD

Clin Pharmacol Ther 80: 396-402; doi:10.1016/j.clpt.2006.07.004

Human Pharmacology of the methamphetamine stereoisomers

John Mendelson MD, Naoto Uemura MD, PhD, Debra Harris MD, Rajneesh P. Nath MD, Emilio Fernandez MD, Peyton Jacob III PhD, E. Thomas Everhart PhD and Reese T. Jones MD

Clin Pharmacol Ther 80: 403-420; doi:10.1016/j.clpt.2006.06.013

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Letter to the Editor

Erythromycin alters the pharmacokinetics of bromocriptine by inhibition of organic anion transporting polypeptide C–mediated uptake

Wen-Jen Lu PhD, Kelly Huang BS, Ming-Liang Lai MD and Jin-ding Huang PhD

Clin Pharmacol Ther 80: 421-422; doi:10.1016/j.clpt.2006.06.003

Effect of S-1 on pharmacokinetics of irinotecan in a patient with colorectal cancer

Koji Yokoo MSc, Hiroshi Watanabe PhD, Akinobu Hamada PhD, Kengo Masa MSc, Hideyuki Saito PhD, Hisayasu Terazaki MD, PhD and Yutaka Sasaki MD, PhD

Clin Pharmacol Ther 80: 422-424; doi:10.1016/j.clpt.2006.06.012

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Notes of The American Society for Clinical Pharmacology and Therapeutics

A Message from The ASCPT Membership Committee Chairperson

John Vincent MD, PhD

Clin Pharmacol Ther 80: 425; doi:10.1016/j.clpt.2006.09.001

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