TABLE OF CONTENTS
Volume 80, Issue 3 (September 2006)
Pharmacodynamics and Drug Action |
Pharmacogenetics and Genomics |
Letter to the Editor |
Notes of The American Society for Clinical Pharmacology and Therapeutics
Pharmacokinetics and Drug Disposition
Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs
Graham Lappin PhD, Wilhelm Kuhnz PhD, Roeline Jochemsen PhD, Johannes Kneer PhD, Ajai Chaudhary PhD, Berend Oosterhuis PhD, Willem Jan Drijfhout PhD, Malcolm Rowland DSc and R. Colin Garner DSc
Clin Pharmacol Ther 80: 203-215; doi:10.1016/j.clpt.2006.05.008
A positron emission tomography microdosing study with a potential antiamyloid drug in healthy volunteers and patients with Alzheimer's disease
Martin Bauer MD, Oliver Langer PhD, Peter Dal-Bianco MD, Rudolf Karch PhD, Martin Brunner MD, Aiman Abrahim, Rupert Lanzenberger MD, Andrea Hofmann MD, Christian Joukhadar MD, Paolo Carminati PhD, Orlando Ghirardi PhD, Paola Piovesan PhD, Gianluigi Forloni PhD, Mario E. Corrado PhD, Nadège Lods PhD, Robert Dudczak MD, Eduard Auff MD, Kurt Kletter PhD and Markus Müller MD
Clin Pharmacol Ther 80: 216-227; doi:10.1016/j.clpt.2006.05.007
The erythromycin breath test reflects P-glycoprotein function independently of cytochrome P450 3A activity
Daniel Kurnik MD, Alastair J. J. Wood MD and Grant R. Wilkinson PhD, DSc
Clin Pharmacol Ther 80: 228-234; doi:10.1016/j.clpt.2006.06.002
Liver disease selectively modulates cytochrome P450–mediated metabolism
Reginald F. Frye PharmD, PhD, Nathalie K. Zgheib MD, Gary R. Matzke PharmD, Diego Chaves-Gnecco MD, MPH, Mordechai Rabinovitz MD, Obaid S. Shaikh MD and Robert A. Branch MD
Clin Pharmacol Ther 80: 235-245; doi:10.1016/j.clpt.2006.05.006
Pharmacodynamics and pharmacokinetics of the urotensin II receptor antagonist palosuran in macroalbuminuric, diabetic patients
Patricia N. Sidharta PharmD, Frank D. Wagner MD, PhD, Holger Bohnemeier MD, Arvid Jungnik MD, Atef Halabi MD, Stephan Krähenbühl MD, PhD, Harbajan Chadha-Boreham PhD and Jasper Dingemanse PharmD, PhD
Clin Pharmacol Ther 80: 246-256; doi:10.1016/j.clpt.2006.05.013
Validation of incorporating flurbiprofen into the Pittsburgh cocktail
Nathalie K. Zgheib MD, Reginald F. Frye PhD, Timothy S. Tracy PhD, Marjorie Romkes PhD and Robert A. Branch MD
Clin Pharmacol Ther 80: 257-263; doi:10.1016/j.clpt.2006.06.005
Pharmacodynamics and Drug Action
Celecoxib, ibuprofen, and the antiplatelet effect of aspirin in patients with osteoarthritis and ischemic heart disease
Giulia Renda MD, PhD, Stefania Tacconelli PhD, Marta L. Capone PhD, Daniele Sacchetta MD, Francesco Santarelli MD, Maria G. Sciulli PhD, Marco Zimarino MD, Marilena Grana MD, Elisabetta D'Amelio PharmD, Maria Zurro PharmD, Thomas S. Price PhD, Carlo Patrono MD, Raffaele De Caterina MD, PhD and Paola Patrignani PhD
Clin Pharmacol Ther 80: 264-274; doi:10.1016/j.clpt.2006.05.004
Intravascular tumor necrosis factor 
blockade reverses endothelial dysfunction in rheumatoid arthritis
Carmine Cardillo MD, Francesca Schinzari MD, Nadia Mores MD, Marco Mettimano MD, Domenico Melina MD, Angelo Zoli MD and Gianfranco Ferraccioli MD
Clin Pharmacol Ther 80: 275-281; doi:10.1016/j.clpt.2006.05.011
Pharmacogenetics and Genomics
Comprehensive evaluation of variability in nicotine metabolism and CYP2A6 polymorphic alleles in four ethnic populations
Miki Nakajima PhD, Tatsuki Fukami MS, Hiroyuki Yamanaka MS, Eriko Higashi MS, Haruko Sakai MS, Ryoko Yoshida MS, Jun-Tack Kwon MD, PhD, Howard L. McLeod PhD and Tsuyoshi Yokoi PhD
Clin Pharmacol Ther 80: 282-297; doi:10.1016/j.clpt.2006.05.012
Letter to the Editor
Is celecoxib an inducer of cytochrome P450 3A4 in subjects carrying the CYP2C9*3 allele?
A. David Rodrigues PhD, Zheng Yang PhD, Cliff Chen MS, Devin Pray MS, Sean Kim PhD and Michael Sinz PhD
Clin Pharmacol Ther 80: 298-301; doi:10.1016/j.clpt.2006.05.009
Reply
Erik Eliasson MD, PhD and Mia Sandberg Lundblad PhD
Clin Pharmacol Ther 80: 301-302; doi:10.1016/j.clpt.2006.05.010
Imaging P-glycoprotein at the human blood-brain barrier
Eric J. F. Franssen PhD, Gert Luurtsema BSc and Adriaan A. Lammertsma PhD
Clin Pharmacol Ther 80: 302-303; doi:10.1016/j.clpt.2006.06.004
Reply
Jashvant D. Unadkat PhD, Jeanne M. Link PhD, David A. Mankoff MD, PhD, Mark Muzi MS and Ann C. Collier MD
Clin Pharmacol Ther 80: 303-304; doi:10.1016/j.clpt.2006.05.014
