TABLE OF CONTENTS
Volume 80, Issue 2 (August 2006)
Pharmacokinetics and Drug Disposition |
Pharmacogenetics and Genomics |
Notes of the America Society for Clinical Pharmacology and Therapeutics
Pharmacodynamics and Drug Action
Reduction in hematocrit level after pioglitazone treatment is correlated with decreased plasma free testosterone level, not hemodilution, in women with polycystic ovary syndrome
Rachele Berria MD, Amalia Gastaldelli PhD, Scott Lucidi MD, Renata Belfort MD, Eleanna De Filippis MD, PhD, Caraan Easton RN, Robert Brytzki MD, Kenneth Cusi MD, Lois Jovanovic MD and Ralph DeFronzo MD
Clin Pharmacol Ther 80: 105-114; doi:10.1016/j.clpt.2006.03.014
Heterogeneity in the suppression of platelet cyclooxygenase-1 activity by aspirin in coronary heart disease
Maria G. Sciulli PhD, Giulia Renda MD, Marta L. Capone PhD, Stefania Tacconelli PhD, Emanuela Ricciotti PhD, Stefano Manarini PhD, Virgilio Evangelista MD, Antonio Rebuzzi MD and Paola Patrignani PhD
Clin Pharmacol Ther 80: 115-125; doi:10.1016/j.clpt.2006.04.011
Pharmacokinetics and Drug Disposition
Potent cytochrome P450 2C19 genotype–related interaction between voriconazole and the cytochrome P450 3A4 inhibitor ritonavir
Gerd Mikus MD, Verena Schöwel, Magdalena Drzewinska, Jens Rengelshausen MD, Reinhard Ding MD, Klaus-Dieter Riedel BSc, Jürgen Burhenne PhD, Johanna Weiss PhD, Torben Thomsen MD and Walter E. Haefeli MD
Clin Pharmacol Ther 80: 126-135; doi:10.1016/j.clpt.2006.04.004
Clinical pharmacokinetics of erlotinib in patients with solid tumors and exposure-safety relationship in patients with non–small cell lung cancer
Jian-Feng Lu PhD, Steve M. Eppler MS, Julie Wolf MS, Marta Hamilton PhD, Ashok Rakhit PhD, Rene Bruno PhD and Bert L. Lum PharmD
Clin Pharmacol Ther 80: 136-145; doi:10.1016/j.clpt.2006.04.007
Quantitative assessment of seminal vesicle and prostate drug concentrations by use of a noninvasive method
Themba T. Ndovi MBBS, PhD, Leena Choi PhD, Brian Caffo PhD, Teresa Parsons PhD, Sharon Baker PharmD, PhD, Ming Zhao PhD, Charles Rohde PhD and Craig W. Hendrix MD
Clin Pharmacol Ther 80: 146-158; doi:10.1016/j.clpt.2006.04.013
Lopinavir/ritonavir reduces lamotrigine plasma concentrations in healthy subjects
Manon J. van der Lee, PharmD, Lara Dawood, Hadewych J.M. ter Hofstede, MD, Marga J.A. de Graaff-Teulen, Eleonora W.J. van Ewijk-Beneken Kolmer, Nurcan Caliskan-Yassen, PharmD, Peter P. Koopmans, MD, PhD and David M. Burger, PharmD, PhD
Clin Pharmacol Ther 80: 159-168; doi:10.1016/j.clpt.2006.04.014
Pharmacogenetics and Genomics
VKORC1 gene variations are the major contributors of variation in warfarin dose in Japanese patients
Kyoko Obayashi BS, Katsunori Nakamura PhD, Junichi Kawana BS, Hiroyasu Ogata PhD, Kazuhiko Hanada PhD, Masahiko Kurabayashi MD, PhD, Akira Hasegawa MD, PhD, Koujirou Yamamoto PhD and Ryuya Horiuchi PhD
Clin Pharmacol Ther 80: 169-178; doi:10.1016/j.clpt.2006.04.010
Impact of the haplotype CYP3A4*16B harboring the Thr185Ser substitution on paclitaxel metabolism in Japanese patients with cancer
Yukiko Nakajima PhD, Takashi Yoshitani PhD, Hiromi Fukushima-Uesaka MSc, Yoshiro Saito PhD, Nahoko Kaniwa PhD, Kouichi Kurose PhD, Shogo Ozawa PhD, Nobuo Aoyagi PhD, Naoyuki Kamatani MD, PhD, Noboru Yamamoto MD, Hideo Kunitoh MD, Yuichiro Ohe MD, Tomohide Tamura MD, Teruhiko Yoshida MD, Hironobu Minami MD, Nagahiro Saijo MD, Noriko Katori PhD and Jun-ichi Sawada PhD
Clin Pharmacol Ther 80: 179-191; doi:10.1016/j.clpt.2006.04.012
Association of enzyme and transporter genotypes with the pharmacokinetics of imatinib
Erin R. Gardner MSc, Herman Burger PhD, Ron H. van Schaik PhD, Allan T. van Oosterom MD, PhD, Ernst A. de Bruijn PhD, Gunther Guetens PhD, Hans Prenen MD, Floris A. de Jong MSc, Sharyn D. Baker PharmD, PhD, Susan E. Bates MD, William D. Figg PharmD, Jaap Verweij MD, PhD, Alex Sparreboom PhD and Kees Nooter PhD
Clin Pharmacol Ther 80: 192-201; doi:10.1016/j.clpt.2006.05.003
